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  • 1
    Electronic Resource
    Electronic Resource
    Purification and immunochemistry of a soluble matrix protein of the chicken eggshell (ovocleidin 17) (1995)
    Springer
    Calcified tissue international 56 (1995), S. 578-583 
    Details
    ISSN: 1432-0827
    Keywords: Eggshell ; Shell matrix ; Biomineralization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The protein components of biomineralized structures (matrix proteins) are believed to modulate crystal nucleation and growth, and theraby influence the shape and strength of the final structure. The chicken eggshell contains a complex array of distinct matrix proteins. The most abundant of these was purified to homogeneity by a combination of anionic exchange and hydroxyapatite chromatographies. Antibodies to this protein were raised in rabbit, and utilized for Western blotting and immunohistochemistry. These studies indicated that the 17 kDa antigen (ovocleidin 17, OC-17) is found in the shell gland mucosa, and that only the tubular gland cells were positive. Immunohistochemistry with decalcified shell indicated that OC-17 is uniformly distributed throughout the shell matrix, but concentrated in the mammillary bodies. Our results indicate that this protein is secreted during shell formation and becomes incorporated into this structure. It may therefore play a role in the crystallization process and influence the properties of the resulting eggshell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00298593
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  • 2
    Electronic Resource
    Electronic Resource
    Differential sensitivity of pancreatic and colon cancer to cyclosporine and α-difluoromethylornithine in vivo (1988)
    Springer
    Investigational new drugs 6 (1988), S. 265-272 
    Details
    ISSN: 1573-0646
    Keywords: polyamines ; pancreatic cancer ; colon cancer ; cyclosporine ; DFMO
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have previously reported that the in vitro growth of MC-26 mouse colon cancer and H2T hamster pancreatic cancer cells are inhibited by cyclosporine (CsA) and α-difluoromethylornithine (DFMO). The present study was designed to investigate the effects of these two drugs on the two experimental tumors (MC-26 and H2T) growing in vivo. Forty-eight male Balb/c mice or Syrian golden hamsters were inoculated with MC-26 (250,000) or H2T (500,000) cells, respectively, and then were randomized into four groups of 12 each: group I was control; group II received CsA; group III received DFMO; group IV received a combination of CsA and DFMO. MC-26 tumors were significantly more sensitive than H2T tumors to the effects of CsA and DFMO. MC-26 tumor growth and tumor weight, as well as the tumor content of DNA, RNA, and protein were all significantly more reduced by CsA and DFMO than were the H2T tumors. Our present study shows that both CsA and DFMO are potent inhibitors of MC-26 colon carcinoma growth in vivo, though DFMO is more than twice as effective as CsA. DFMO also produced greater reductions in the tumor content of DNA, RNA, and protein than did CsA. DFMO significantly decreased the concentrations of polyamines in both H2T and MC-26 tumors; the MC-26 tumors were affected to a greater degree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173644
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  • 3
    Electronic Resource
    Electronic Resource
    2-deoxy-D-glucose inhibits the antitumor effects of α-difluoromethylornithine on the growth of colon cancer in vivo (1989)
    Springer
    Investigational new drugs 7 (1989), S. 131-138 
    Details
    ISSN: 1573-0646
    Keywords: polyamines ; cancer ; 2-deoxy-D-glucose ; α-difluoromethylornithine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), has been shown to inhibit the growth of certain cancers. α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), the ratelimiting enzyme in polyamine biosynthesis. DFMO has been shown to inhibit cancer growth in a number of models. The present study was designed to investigate the effects of 2-DG alone and combined with DFMO on MC-26 mouse colon adenocarcinoma tumors growing in vivo. Twenty-eight male Balb/c mice were inoculated with 250,000 MC-26 cells, and then randomized into four groups of 7 each: group I served as control; group II received DFMO (3% in drinking water); group III received 2-DG (500 mg/kg/d IP); group IV received a combination of 2-DG and DFMO. Treatment began 5 days after tumor cell inoculation. MC-26 tumor area was reduced 73% by DFMO compared to a 24% reduction caused by 2-DG. The tumor weight was reduced 80% by DFMO and 52% by 2-DG. The tumor contents of DNA, RNA, and protein were significantly reduced by DFMO but not 2-DG. The tumor concentration of the polyamines putrescine and spermidine were reduced by DFMO alone or combined with 2-DG while spermine levels remained unchanged. 2-DG alone did not alter polyamine levels. These results indicate that both 2-DG and DFMO, when added as single agents, inhibit tumor growth. However, the addition of 2-DG to the DFMO regimen inhibited the antitumor effects of DFMO. Survival studies performed on MC-26 cells in vitro corroborated the antagonisms between DFMO and 2-DG that were shown in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170849
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  • 4
    Electronic Resource
    Electronic Resource
    In search of a gust definition (1991)
    Springer
    Boundary layer meteorology 55 (1991), S. 91-107 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We propose a simple gust definition based on the theory of excursions by Rice (1944 and 1945). We discuss the relation to the distribution of extreme events and demonstrate theoretically and experimentally that the most probable extreme event is very close to being identical to the gust according to our definition. We demonstrate how it is possible to predict the gust on the basis of the measured mean wind and variance rather than rely on actually measured extreme excursions. Our gust definition also allows us to predict the average duration of a gust.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00119328
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  • 5
    Electronic Resource
    Electronic Resource
    The spectral velocity tensor for homogeneous boundary-layer turbulence (1989)
    Springer
    Boundary layer meteorology 47 (1989), S. 149-193 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We have postulated a simple model for the spectral tensor Φ ij (k) of an anisotropic, but homogeneous turbulent velocity field. It is a simple generalization of the spectral tensor Φ inf ij piso(k) for isotropic turbulence and we show how in the limit of isotropy, Φ ij (k) becomes equal to Φ inf ij piso(k). Whereas Φ inf ij piso(k) is determined entirely by one scalar function of k = ¦k¦, namely the energy spectrum, we need three independent scalar functions of k to specify Φ ij (k). We show how it is possible by means of the three stream-wise velocity component spectra to determine the three scalar functions in Φ ij (k) by solving two uncoupled, ordinary linear differential equations of first and second order. The analytic form of the component spectra each has a set of three parameters: the variance and the integral length scale of the velocity component and a dimensionless parameter, which governs the curvature of the spectrum in the transition domain from the inertial subrange towards lower wave numbers. When the three sets of parameters are the same, the three spectra correspond to isotropic turbulence and they are all interrelated and related to the energy spectrum. We show how it is possible to obtain these spectral forms in the neutral surface layer and in the convective boundary layer from data reported in the literature. The spectral tensor is used to predict the lateral coherences for all three velocity components and these predictions are compared with coherences obtained in two experiments, one using three masts at a horizontally homogeneous site in Denmark and one employing two aircraft flying in formation over eastern Colorado. Comparison shows reasonable agreement although with considerable experimental scatter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00122327
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  • 6
    Electronic Resource
    Electronic Resource
    Cyclosporine and α-difluoromethylornithine exhibit differential effects on colon and pancreatic cancer in vitro (1987)
    Springer
    Investigational new drugs 5 (1987), S. 251-258 
    Details
    ISSN: 1573-0646
    Keywords: cancer ; cyclosporine ; pancreas ; colon ; polyamines ; α-difluoromethylornithine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract α-Difluoromethylornithine (DFMO) is a known irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Cyclosporine (CsA) has been reported to inhibit ODC activity in vitro. In the present study, we compared the effects of DFMO and CsA on growth, survival, and polyamine levels in mouse colon cancer (MC-26) and hamster pancreatic cancer (H2T) cells in vitro. The growth and survival of MC-26 and H2T cells were inhibited by both DFMO and CsA. However, H2T cells were observed to be significantly more sensitive than MC-26 cells to both CsA and DFMO. The inhibitory effects of CsA were blocked by the addition of the polyamine, putrescine, in both MC-26 and H2T cells. Polyamine levels were altered significantly in both MC-26 and H2T cells treated with CsA and DFMO. However, the profile of these alterations differed between MC-26 and H2T cell lines. Putrescine and spermidine levels in MC-26 cells were more sensitive to DFMO inhibition than were H2T cells. Spermine levels were consistently elevated in MC-26 cells exposed to CsA or DFMO, while the level of spermine in H2T cells decreased significantly in response to the same drugs. These results suggest that CsA and DFMO exhibit different effects on colon and pancreatic cancer growth in vitro. In addition, the differences in the sensitivity of pancreatic and colon cancer to CsA and DFMO indicate potentially important differences in polyamine metabolism between the two cell lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175295
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  • 7
    Electronic Resource
    Electronic Resource
    Changes in drug sensitivity of a human astrocytoma clone previously treated with 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea in vitro (1988)
    Springer
    Investigational new drugs 6 (1988), S. 293-298 
    Details
    ISSN: 1573-0646
    Keywords: drug resistance ; astrocytoma ; radiation ; nitrosourea ; adriamycin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have shown in earlier studies that repeated weekly exposures of a human astrocytoma clone (AST 3–4) to MeCCNU (10 μg/ml for 1 h per week) produced a linear decrease in survival over the first 3 weekly treatments. But, after that time these cells became progressively more resistant to the 10 μg/ml concentration of the agent. In the studies reported here we show that these previously treated cells were also less responsive to other doses ranging from 1 to 30 μg MeCCNU/ml. This change in sensitivity to MeCCNU was accompanied by collateral changes in response to other agents: resistance to BCNU and Galactitol, increased sensitivity to Adriamycin, and no change to ionizing radiation. These experiments suggest that once repeated treatments with a single agent cause a tumor cell population to become more resistant, sensitivity to other agents may also change unpredictably.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173647
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  • 8
    Electronic Resource
    Electronic Resource
    Schedule dependent potentiation of antitumor drug effects by α-difluoromethylornithine in human gastric carcinoma cells in vitro (1990)
    Springer
    Investigational new drugs 8 (1990), S. S9 
    Details
    ISSN: 1573-0646
    Keywords: stomach cancer ; polyamines ; αDFMO ; heterogeneity ; cell killing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A clone of human gastric cancer cells (AGS-6) and the parental line (AGS-P) from which it was isolated were used in cell survival studies to determine whether pretreatment for 24, 48 or 72h with α-difluoromethylornithine (DFMO, 5mM) would increase the cell's sensitivity to 5-Fluorouracil (5FU), Adriamycin (Adria), 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU), or Bleomycin (Bleo). Generally, the AGS parental cells were most sensitive to the anticancer agents after exposures to DFMO. However, there was no way to predict in advance from DFMO-induced changes in ornithine decarboxylase (ODC), polyamine or cell kinetics values, how long an exposure to DFMO was required before sensitization to an anticancer agent occurred. The degree of potentiation for a single drug was variable from time to time during exposure to DFMO, and broad differences in the sensitizations were demonstrated among the four anticancer drugs. The AGS-6 clone exhibited little or no increased sensitivity as a result of pretreatment with DFMO, even though the DFMO-induced reductions in ODC and polyamine values in these cells were similar to those produced in the more sensitive parental line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171979
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  • 9
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    Abstracts of the 6th FECS Conference 1998 Lectures (1998)
    Springer
    Details
    Publication Date: 1998-09-01
    Print ISSN: 0944-1344
    Electronic ISSN: 1614-7499
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Springer
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  • 10
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    Synthesis and Properties of Lightly Crosslinked Poly((meth)acrylic acid) Microparticles Prepared by Free Radical Precipitation Polymerization (2006)
    Springer
    Details
    Publication Date: 2006-02-21
    Print ISSN: 0170-0839
    Electronic ISSN: 1436-2449
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Published by Springer
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