ISSN:
1420-9071
Keywords:
Benzodiazepine
;
circadian rhythm
;
gamma-aminobutyric acid
;
inverse agonist
;
suprachiasmatic nucleus
;
triazolam
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The benzodiazepine triazolam, the benzodiazepine inverse agonist, β-methyl carboline (β-CCM) or both, were administered to adult male hamsters under conditions of constant light. When given alone, triazolam induced phase advances in the circadian activity rhythm of about 90 min, while β-CCM when given alone, had no effect on phase of the activity rhythm. However, when triazolam and β-CCM were given at the same time, the magnitude of the phase advances induced by triazolam were attenuated to about 30 min. These data, in conjunction with previous results, provide pharmacological evidence for a GABAergic system involved in the regulation of a central circadian pacemaker.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01957468
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