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  • Molecular Diversity Preservation International  (2)
  • Cambridge University Press  (1)
  • 1
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    Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction (2019)
    Molecular Diversity Preservation International
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    Publication Date: 2019-07-20
    Description: Dyslipidemia is a common nutritional and metabolic disorder in patients with chronic kidney disease. Accumulating evidence supports the hypothesis that prolonged metabolic imbalance of lipids leads to ectopic fat distribution in the peripheral organs (lipotoxicity), including the kidney, heart, and skeletal muscle, which accelerates peripheral inflammation and afflictions. Thus, lipotoxicity may partly explain progression of renal dysfunction and even extrarenal complications, including renal anemia, heart failure, and sarcopenia. Additionally, endoplasmic reticulum stress activated by the unfolded protein response pathway plays a pivotal role in lipotoxicity by modulating the expression of key enzymes in lipid synthesis and oxidation. Here, we review the molecular mechanisms underlying lipid deposition and resultant tissue damage in the kidney, heart, and skeletal muscle, with the goal of illuminating the nutritional aspects of these pathologies.
    Electronic ISSN: 2072-6643
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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  • 2
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    Uremic Sarcopenia: Clinical Evidence and Basic Experimental Approach (2020)
    Molecular Diversity Preservation International
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    Publication Date: 2020-06-18
    Description: Sustained physical activity extends healthy life years while a lower activity due to sarcopenia can reduce them. Sarcopenia is defined as a decrease in skeletal muscle mass and strength due not only to aging, but also from a variety of debilitating chronic illnesses such as cancer and heart failure. Patients with chronic kidney disease (CKD), who tend to be cachexic and in frail health, may develop uremic sarcopenia or uremic myopathy due to an imbalance between muscle protein synthesis and catabolism. Here, we review clinical evidence indicating reduced physical activity as renal function deteriorates and explore evidence-supported therapeutic options focusing on nutrition and physical training. In addition, although sarcopenia is a clinical concept and difficult to recapitulate in basic research, several in vivo approaches have been attempted, such as rodent subtotal nephrectomy representing both renal dysfunction and muscle weakness. This review highlights molecular mechanisms and promising interventions for uremic sarcopenia that were revealed through basic research. Extensive study is still needed to cast light on the many aspects of locomotive organ impairments in CKD and explore the ways that diet and exercise therapies can improve both outcomes and quality of life at every level.
    Electronic ISSN: 2072-6643
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Published by Molecular Diversity Preservation International
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  • 3
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    Late Jurassic–Early Cretaceous intra-arc sedimentation and volcanism linked to plate motion change in northern Japan (2006)
    Cambridge University Press
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    Publication Date: 2006-09-04
    Description: The Sorachi Group, composed of Upper Jurassic ophiolite and Lower Cretaceous island-arc volcano-sedimentary cover, provides a record of Late Jurassic–Early Cretaceous sedimentation and volcanism in an island-arc setting off the eastern margin of the Asian continent. Stratigraphic changes in the nature and volume of the Sorachi Group volcanic and volcaniclastic rocks reveal four tectonic stages. These stages resulted from changes in the subduction direction of the Pacific oceanic plate. Stage I in the Late Jurassic was characterized by extensive submarine eruptions of tholeiitic basalt from the back-arc basin. Slab roll-back caused rifting and sea-floor spreading in the supra-subduction zone along the active Asian continental margin. Stage II corresponded to the Berriasian and featured localized trachyandesitic volcanism that formed volcanic islands with typical island-arc chemical compositions. At the beginning of this stage, movement of the Pacific oceanic plate shifted from northeastward to northwestward. During Stage III, in the Valanginian, submarine basaltic volcanism was followed by subsidence. The Pacific oceanic plate motion turned clockwise, and the plate boundary between the Asian continent and the Pacific oceanic plate changed from convergent to transform. During Stage IV in the Hauterivian–Barremian, in situ volcanism ceased in the Sorachi–Yezo basin, and the volcanic front migrated west of the Sorachi–Yezo basin.
    Print ISSN: 0016-7568
    Electronic ISSN: 1469-5081
    Topics: Geosciences
    Published by Cambridge University Press
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