ISSN:
1573-6822
Keywords:
acetylaminostilbene
;
aromatic amines
;
deacetylase
;
gene mutation assays
;
paraoxon
;
thioguanine resistance
;
V79 cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
The N-acetoxy and N-hydroxy derivatives of trans-4-acetylamino-stilbene (AAS) were demonstrated to induce gene mutations at the hgprt locus and to be cytotoxic in V79 cells. These cells deacetylated AAS. Paraoxon inhibited the deacetylation of AAS by more than 99% and reduced the mutagenicicity and cytotoxicity of N-hydroxy-ASS and N-acetoxy-AAS to about one-tenth. Hence, deacetylated metabolites, formed by the target cells, were important for the observed biological effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00122690
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