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An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer (2020)

Wang, Jia-Bin ; Li, Ping ; Liu, Xiao-Long ; [weitere]

Springer Nature

In: Nature Communications. 2020; 11(1): 6352. Published 2020 Dec 01. doi: 10.1038/s41467-020-20260-7.

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Publikationsdatum: 2020-12-01

Beschreibung: Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of different immunosuppressive molecules makes it very difficult to accurately predict clinical outcomes based only on a single immunosuppressive molecule. Here, we establish a comprehensive immune scoring system (ISSGC) based on 6 immunosuppressive ligands (NECTIN2, CEACAM1, HMGB1, SIGLEC6, CD44, and CD155) using the LASSO method to improve prognostic accuracy and provide an additional selection strategy for adjuvant chemotherapy of gastric cancer (GC). The results show that ISSGC is an independent prognostic factor and a supplement of TNM stage for GC patients, and it can improve their prognosis prediction accuracy; in addition, it can distinguish GC patients with better prognosis from those with high prognostic nutritional index score; furthermore, ISSGC can also be used as a tool to select GC patients who would benefit from adjuvant chemotherapy independent of their TNM stages, MSI status and EBV status.

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Three-dimensionally bonded spongy graphene material with super compressive elasticity and near-zero Poisson’s ratio (2015)

Yingpeng Wu; Ningbo Yi; Lu Huang; Tengfei Zhang; Shaoli Fang; Huicong Chang; Na Li; Jiyoung Oh; Jae Ah Lee; Mikhail Kozlov; Alin C. Chipara; Humberto Terrones; Peishuang Xiao; Guankui Long; Yi Huang; Fan Zhang; Long Zhang; Xavier LepróCarter Haines; Márcio Dias Lima; Nestor Perea Lopez; Lakshmy P. Rajukumar; Ana L. Elias; Simin Feng; Seon Jeong Kim; N. T. Narayanan; Pulickel M. Ajayan; Mauricio Terrones; Ali Aliev; Pengfei Chu; Zhong Zhang; Ray H. Baughman; Yongsheng Chen

Springer Nature

In: Nature Communications

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Publikationsdatum: 2015-01-22

Beschreibung: Article The incorporation of the desirable properties of graphene into three-dimensional materials remains challenging. Here, the authors report the scalable self-assembly of graphene sheets into spongy materials with very low densities, and near-zero and largely strain-independent Poisson's ratios in all directions. Nature Communications doi: 10.1038/ncomms7141 Authors: Yingpeng Wu, Ningbo Yi, Lu Huang, Tengfei Zhang, Shaoli Fang, Huicong Chang, Na Li, Jiyoung Oh, Jae Ah Lee, Mikhail Kozlov, Alin C. Chipara, Humberto Terrones, Peishuang Xiao, Guankui Long, Yi Huang, Fan Zhang, Long Zhang, Xavier Lepró, Carter Haines, Márcio Dias Lima, Nestor Perea Lopez, Lakshmy P. Rajukumar, Ana L. Elias, Simin Feng, Seon Jeong Kim, N. T. Narayanan, Pulickel M. Ajayan, Mauricio Terrones, Ali Aliev, Pengfei Chu, Zhong Zhang, Ray H. Baughman, Yongsheng Chen

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls (2015)

Zezhang Zhu; Nelson Leung-Sang Tang; Leilei Xu; Xiaodong Qin; Saihu Mao; Yueming Song; Limin Liu; Fangcai Li; Peng Liu; Long Yi; Jiang Chang; Long Jiang; Bobby Kin-Wah Ng; Benlong Shi; Wen Zhang; Jun Qiao; Xu Sun; Xusheng Qiu; Zhou Wang; Fei Wang; Dingding Xie; Ling Chen; Zhonghui Chen; Mengran Jin; Xiao Han; Zongshan Hu; Zhen Zhang; Zhen Liu; Feng Zhu; Bang-ping Qian; Yang Yu; Bing Wang; K. M. Lee; Wayne Y.W. Lee; T. P. Lam; Yong Qiu; Jack Chun-Yiu Cheng

Springer Nature

In: Nature Communications

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Publikationsdatum: 2015-09-24

Beschreibung: Article The authors perform a genome-wide association study of adolescent idiopathic scoliosis patients of Han Chinese descent, and identify 3 new loci for disease susceptibility. Nature Communications doi: 10.1038/ncomms9355 Authors: Zezhang Zhu, Nelson Leung-Sang Tang, Leilei Xu, Xiaodong Qin, Saihu Mao, Yueming Song, Limin Liu, Fangcai Li, Peng Liu, Long Yi, Jiang Chang, Long Jiang, Bobby Kin-Wah Ng, Benlong Shi, Wen Zhang, Jun Qiao, Xu Sun, Xusheng Qiu, Zhou Wang, Fei Wang, Dingding Xie, Ling Chen, Zhonghui Chen, Mengran Jin, Xiao Han, Zongshan Hu, Zhen Zhang, Zhen Liu, Feng Zhu, Bang-ping Qian, Yang Yu, Bing Wang, K. M. Lee, Wayne Y.W. Lee, T. P. Lam, Yong Qiu, Jack Chun-Yiu Cheng

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Hand-Assisted Thoracoscopic Surgery for Pulmonary Metastasectomy through Sternocostal Triangle Access: Superiority in Detection of Non-Imaged Pulmonary Nodules (2014)

Long Hao; Jiang Long; Lin Yong; Bin; Situ Dong; Rong; Zheng Yan; Zhang Yi; Gong; Ma Guo; Wei

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2014-04-02

Beschreibung: Hand-Assisted Thoracoscopic Surgery for pulmonary metastasectomy through sternocostal triangle access allows manual palpation of both lungs, thus permitting effective treatment of lung metastases. In our research, 62 patients from November 2001 to January 2012 underwent our Hand-Assisted Thoracoscopic Surgery procedures for pulmonary metastasectomy. Clinical data, including the number of pulmonary metastases determined by Computed Tomography/Positron Emission Tomography-Computed Tomography, surgical findings and survival data of these patients were collected. We found that the median follow-up time was 23.7 months (range 2.4 to 85.6 months). 30 cases of them had post-operative recurrences and the median disease-free survival period was 27.4 months. For Computed Tomography scan, the overall sensitivity for proved metastases was 63% (115/182). 67 non-imaged malignant nodules were palpated and removed in 14 cases. For Positron Emission Tomography-Computed Tomography scan, the overall sensitivity was 66% (79/120). 41 non-imaged malignant nodules were palpated and removed in 12 cases. This study show that the Hand-Assisted Thoracoscopic Surgery provides an easier way for routine bilateral pleural exploration, and thus is critical and effective in detection of non-imaged malignant pulmonary metastases, which might contribute to long-term disease-free survival. Scientific Reports 4 doi: 10.1038/srep04539

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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In-situ X-ray diffraction snapshotting: Determination of the kinetics of a photodimerization within a single crystal (2014)

Fei-Long Hu; Shu-Long Wang; Jian-Ping Lang; Brendan F. Abrahams

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2014-10-30

Beschreibung: In a single-crystal-to-single-crystal (SCSC) transformation, a preformed three-dimensional coordination polymer,[Ni3(oba)2(bpe)2(SO4)(H2O)4]·H2O (H2oba = 4,4′-oxydibenzoic acid; bpe = (E)-1,2-di(pyridin-4-yl)ethane) (1), was shown to undergo a [2+2] cycloaddition reaction upon exposure to UV irradiation. The kinetics of this reaction were followed by taking “snapshots” of the solid state transformation using in situ single crystal X-ray crystallography; a first order process was indicated. The reaction rate was influenced by many factors such as the separation of the sample from the UV light source, the heat produced by the UV irradiation, the light flux of the UV lamp used, the size of the single-crystal and the powder samples. The investigation of the kinetics was complemented by 1H NMR studies. The results clearly demonstrate that in situ single-crystal X-ray diffraction is able to provide useful insights into the gradual formation of the photoproducts and the reaction processes. The work also offers a clear indication that it is possible to use the technique to study the kinetics of other photocycloaddition reactions and SCSC processes in general. Scientific Reports 4 doi: 10.1038/srep06815

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa (2015)

Xiangyu Ma; Liping Guan; Wei Wu; Yao Zhang; Wei Zheng; Yu-Tang Gao; Jirong Long; Na Wu; Long Wu; Ying Xiang; Bin Xu; Miaozhong Shen; Yanhua Chen; Yuewen Wang; Ye Yin; Yingrui Li; Haiwei Xu; Xun Xu; Yafei Li

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2015-03-19

Beschreibung: Retinitis pigmentosa (RP), a heterogeneous group of inherited ocular diseases, is a genetic condition that causes retinal degeneration and eventual vision loss. Though some genes have been identified to be associated with RP, still a large part of the clinical cases could not be explained. Here we reported a four-generation Chinese family with RP, during which 6 from 9 members of the second generation affected the disease. To identify the genetic defect in this family, whole-exome sequencing together with validation analysis by Sanger sequencing were performed to find possible pathogenic mutations. After a pipeline of database filtering, including public databases and in-house databases, a novel missense mutation, c. 424 C 〉 T transition (p.R142W) in OR2W3 gene, was identified as a potentially causative mutation for autosomal dominant RP. The mutation co-segregated with the disease phenotype over four generations. This mutation was validated in another independent three-generation family. RT-PCR analysis also identified that OR2W3 gene was expressed in HESC-RPE cell line. The results will not only enhance our current understanding of the genetic basis of RP, but also provide helpful clues for designing future studies to further investigate genetic factors for familial RP. Scientific Reports 5 doi: 10.1038/srep09236

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Whole-genome sequencing of Berkshire (European native pig) provides insights into its origin and domestication (2014)

Mingzhou Li; Shilin Tian; Carol K. L. Yeung; Xuehong Meng; Qianzi Tang; Lili Niu; Xun Wang; Long Jin; Jideng Ma; Keren Long; Chaowei Zhou; Yinchuan Cao; Li Zhu; Lin Bai; Guoqing Tang; Yiren Gu; An'an Jiang; Xuewei Li; Ruiqiang Li

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2014-04-15

Beschreibung: Domesticated organisms have experienced strong selective pressures directed at genes or genomic regions controlling traits of biological, agricultural or medical importance. The genome of native and domesticated pigs provide a unique opportunity for tracing the history of domestication and identifying signatures of artificial selection. Here we used whole-genome sequencing to explore the genetic relationships among the European native pig Berkshire and breeds that are distributed worldwide, and to identify genomic footprints left by selection during the domestication of Berkshire. Numerous nonsynonymous SNPs-containing genes fall into olfactory-related categories, which are part of a rapidly evolving superfamily in the mammalian genome. Phylogenetic analyses revealed a deep phylogenetic split between European and Asian pigs rather than between domestic and wild pigs. Admixture analysis exhibited higher portion of Chinese genetic material for the Berkshire pigs, which is consistent with the historical record regarding its origin. Selective sweep analyses revealed strong signatures of selection affecting genomic regions that harbor genes underlying economic traits such as disease resistance, pork yield, fertility, tameness and body length. These discoveries confirmed the history of origin of Berkshire pig by genome-wide analysis and illustrate how domestication has shaped the patterns of genetic variation. Scientific Reports 4 doi: 10.1038/srep04678

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Tumor necrosis factor-alpha 308G〉A polymorphism and risk of rheumatic heart disease: a meta-analysis (2014)

Ruo-long Zheng; Hua Zhang; Wen-long Jiang

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2014-04-23

Beschreibung: Rheumatic heart disease (RHD) remains a serious cardiovascular disorder across the world. Tumor necrosis factor alpha (TNF-α) codifies a potent immunomodulator and pro-inflammatory cytokine that mediates diverse pathological processes. A promoter 308G〉A polymorphism in TNF-α has been implicated in RHD risk. However, the results remain controversial. Therefore, to evaluate more precise estimations of the relationship, a meta-analysis was performed. A total of 7 studies including 735 RHD cases and 926 controls were involved in this meta-analysis. Overall, our results revealed that there was a significant association with RHD risk in three genetic models (homozygous model: OR = 3.06, 95%CI = 1.22–10.60, P = 0.020; dominant model, OR = 2.03, 95%CI = 1.01–4.07, P = 0.048; and recessive model, OR = 4.26, 95%CI = 2.41–7.55, P 〈 0.001). Further ethnic population analysis found a significantly increased risk of RHD among Asians and Europeans. Interestingly, similar results were found among hospital-based studies. Begg's funnel plot and Egger's test did not reveal any publication bias. Taken together, this meta-analysis demonstrates that the TNF-α 308G〉A polymorphism is associated with RHD susceptibility, and it contributes to the increased risk of RHD. However, additional well-designed studies with larger samples are warranted to confirm these findings. Scientific Reports 4 doi: 10.1038/srep04731

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Electron delocalization and charge mobility as a function of reduction in a metal–organic framework (2018)

Michael L. Aubrey; Brian M. Wiers; Sean C. Andrews; Tsuneaki Sakurai; Sebastian E. Reyes-Lillo; Samia M. Hamed; Chung-Jui Yu; Lucy E. Darago; Jarad A. Mason; Jin-Ook Baeg; Fernande Grandjean; Gary J. Long; Shu Seki; Jeffrey B. Neaton; Peidong Yang; Jeffrey R. Long

Springer Nature

In: Nature Materials

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Publikationsdatum: 2018-06-05

Beschreibung: Electron delocalization and charge mobility as a function of reduction in a metal–organic framework Electron delocalization and charge mobility as a function of reduction in a metal–organic framework, Published online: 04 June 2018; doi:10.1038/s41563-018-0098-1 A conducting metal–organic framework with charge delocalization by reductive potassium insertion is demonstrated. Integration into a field-effect transistor shows similar mobilities to semiconductors, with a mobility estimated to be at least 0.84 cm2 V–1 s–1.

Print ISSN: 1476-1122

Digitale ISSN: 1476-4660

Thema: Chemie und Pharmazie , Maschinenbau , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Identification of QTN and candidate genes for Salinity Tolerance at the Germination and Seedling Stages in Rice by Genome-Wide Association Analyses (2018)

Shahzad Amir Naveed; Fan Zhang; Jian Zhang; Tian-Qing Zheng; Li-Jun Meng; Yun-Long Pang; Jian-Long Xu; Zhi-Kang Li

Springer Nature

In: Scientific Reports

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Publikationsdatum: 2018-04-26

Beschreibung: Identification of QTN and candidate genes for Salinity Tolerance at the Germination and Seedling Stages in Rice by Genome-Wide Association Analyses Identification of QTN and candidate genes for Salinity Tolerance at the Germination and Seedling Stages in Rice by Genome-Wide Association Analyses, Published online: 25 April 2018; doi:10.1038/s41598-018-24946-3 Identification of QTN and candidate genes for Salinity Tolerance at the Germination and Seedling Stages in Rice by Genome-Wide Association Analyses

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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