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B-lymphocyte mitogenicity and adjuvanticity of an ornithine-containing lipid or a serine-containing lipid (1991)

Kawai, Y. ; Kamoshita, K. ; Akagawa, K.

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 83 (1991), S. 0

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ISSN: 1574-6968

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: Abstract: An ornithine-containing lipid (Orn-L) or a serine-containing lipid (Ser-L) from Flavobacterium meningosepticum exhibited strong mitogenicity for the splenocytes from both LPS-responder C3H/HeSlc and LPS-low-responder C3H/HeJ mice. The potency of the lipoamino acids was the same as that of LPS for responder mice. The lipoamino acids were B-lymphocyte mitogens. Furthermore, Orn-L or Ser-L exhibited strong adjuvanticity. Compared with the adjuvanticity of LPS, the activity of Orn-L was rather high. Based on these data, together with the previously reported data of macrophage activation, we propose that the lipoamino acids are non-toxic, potent immunoactivators.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1574-6968.1988.tb02705.x-i1

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