Publication Date:
2009-05-29
Description:
Background The role of the Fcγ receptor IIa (FcγRIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of FcγRIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples. Methods FcγRIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis ≥ 50%, were compared with 1032 individuals with stenosis
Electronic ISSN:
1471-2350
Topics:
Biology
,
Medicine
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