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  • 1
    Digitale Medien
    Digitale Medien
    Inorganic Nitrogen Metabolism (1958)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 12 (1958), S. 203-246 
    Details
    ISSN: 0066-4227
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.mi.12.100158.001223
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  • 2
    Digitale Medien
    Digitale Medien
    A Morphometric Comparison of Trabecular Structure of Human Ilium Between Microcomputed Tomography and Conventional Histomorphometry (1997)
    Springer
    Calcified tissue international 61 (1997), S. 493-498 
    Details
    ISSN: 1432-0827
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. Recently, an imaging technique using microcomputed tomography (micro-CT) has emerged as a method for nondestructively assessing the microarchitecture of unprocessed surgical bone biopsy specimens. Using micro-CT, two-dimensional (2D) axial images were obtained from undecalcified transiliac bone biopsies which were taken from 15 patients with various metabolic bone diseases. Total area, bone area, and bone perimeter were determined, from which the bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) were calculated semiautomatically and instantaneously. To evaluate the validity of this technique as a useful tool, the results were compared with those obtained from conventional histomorphometry. There were significant correlations between the two techniques for all parameters, with correlation coefficients ranging from 0.759 (Tb.N, P 〈 0.005) to 0.949 (BV/TV, P 〈 0.0001). Different resolutions seem to lead to major differences in perimeter values measured by the two methods. These factors may explain why the correlation coefficients of Tb.N and Tb.Th estimated from the perimeter and area is lower than that of BV/TV. Our results show that the micro-CT based on 2D images is a useful tool for imaging and nondestructively quantifying the microarchitecture of trabecular bone in unprocessed surgical bone specimens.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002239900373
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  • 3
    Digitale Medien
    Digitale Medien
    Influence of Grip Strength on Metacarpal Bone Mineral Density in Postmenopausal Japanese Women: A Cross-Sectional Study (1999)
    Springer
    Calcified tissue international 64 (1999), S. 263-266 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Key words: Grip strength — bone mineral density — Postmenopausal — Japanese women — Lifestyle.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. Most published studies on the role of muscle strength in the maintenance of bone mineral density (BMD) focused on the relationship between specific muscle groups and adjacent bones, mostly in young and premenopausal women. This study examined the influence of grip strength on BMD of the metacarpal index in postmenopausal Japanese women. Subjects included 1168 postmenopausal women aged 40–70 years. BMD measurement was done with computed X-ray densitometry (CXD) by analyzing X-ray films of the right second metacarpal index. Grip strength was measured in both the dominant and nondominant hands using a squeeze dynamometer. Grip strength (r = 0.2474; P= 0.0001) and age (r =−0.5443; P= 0.0001) significantly correlated positively and negatively, respectively, with BMD. Physical activity (r = 0.1318; P= 0.0001) also correlated positively with BMD. Breastfeeding (r =−0.1658; P= 0.0001), however, correlated negatively with BMD. Subjects with a history of regular physical activity had higher grip strengths and BMD, than those with no physical activity. Adjustment for age, physical activity, calcium intake, BMI, breastfeeding, testing site, and menopausal type indicated a significant (P for trend = 0.0013) positive association of grip strength with BMD. Subjects with stronger grip strengths had a decreased risk for low BMD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002239900615
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  • 4
    Digitale Medien
    Digitale Medien
    Peripheral Quantitative Computed Tomography of the Femoral Neck in 60 Japanese Women (1999)
    Springer
    Calcified tissue international 65 (1999), S. 447-453 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Key words: Peripheral quantitative computed tomography — Femoral neck-bone mineral density — Geometry — Osteoporotic fracture.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. Peripheral quantitative computed tomography (pQCT) is able to evaluate trabecular and cortical bone separately, and to determine geometric properties from cross-sectional images for noninvasive assessments of mechanical strength. In order to assess the diagnostic value of pQCT of the femoral neck, 60 healthy women were examined with a new pQCT machine, XCT-3000 (Norland-Stratec, Germany), which is suitable for direct measurement of the hip. The region of interest chosen was the center of the femoral neck. pQCT of the distal radius and dual energy X-ray absorptiometry (DXA) of the lumbar spine and femoral neck were also performed. The study demonstrated that total bone mineral density (BMD) (femoral MD) and trabecular BMD (femoral-TBD) decreased with advancing age. Percent cortical area showed a small but significant decrease with advancing age and % trabecular area increased slightly. Both the endosteal perimeter and the periosteal perimeter were relatively constant with aging. Bone strength index (BSI) and stress-strain index (SSI), which reflect the mechanical strength of bone, declined with advancing age, especially after menopause. Femoral TBD correlated strongly with femoral neck BMD by DXA and L2-L4 BMD by DXA but femoral-CBD did not correlate with femoral neck BMD by DXA. Volumetric BMD of the femoral neck and distal radius were closely correlated. It is concluded that (1) cortical thinning occurs with aging by endocortical resorption and loss of femoral-TBD; (2) loss of femoral-CBD occurred at a slower rate than radial CBD, perhaps due to the weight-bearing effect; (3) biomechanical parameters such as the BSI and SSI may reflect increasing fragility of the femoral neck in pre- and postmenopausal women; (4) pQCT of the femoral neck had diagnostic value at least equivalent to that of DXA or pQCT of the distal radius.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002239900731
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  • 5
    Digitale Medien
    Digitale Medien
    Bone mineral density and bone histomorphometric assessments of postpregnancy osteoporosis: A report of five patients (1994)
    Springer
    Calcified tissue international 54 (1994), S. 20-25 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Idiopathic osteoporosis ; Pregnancy ; Lactation ; Bone mineral density ; Bone histomorphometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract Reports of five young women who developed vertebral fractures associated with pregnancy and lactation are presented (Fig. 1). Ages ranged from 24 to 37 (mean 30) years. All five patients have osteoporosis with two to nine vertebral fractures at presentation postpartum. Bone mineral density (BMD) was measured by single-photon absorptiometry, quantitative computer tomography, and dual-energy X-ray absorptiometry. BMD of the trabecular bone was less than normal values and it remained apparently low even several years after pregnancy. Histological findings of bone biopsy identified the bone loss with increasing bone resorption. Our present findings suggest that postpregnancy osteoporosis affects mainly the trabecular bone site, and the patients might have low peak bone mass and poor reversibility probably due to a low rate of remodeling.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00316284
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  • 6
    Digitale Medien
    Digitale Medien
    Naloxone prevents the analgesic action of α-MSH in mice (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 627-628 
    Details
    ISSN: 1420-9071
    Schlagwort(e): α-MSH ; analgesia ; naloxone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary α-MSH (0.1, 1, 10 μg) was administered intracerebroventricularly and its action on pain sensitivity was investigated by the hot-plate method in mice. α-MSH produced dose-dependent analgesia and this analgesic effect was prevented by naloxone (1 mg/kg, s.c.). It is possible that α-MSH may play a role in the mechanism of pain through endogeneous opioid systems.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02007691
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  • 7
    Digitale Medien
    Digitale Medien
    Copper metabolism in the LEC rat: Involvement of induction of metallothionein and disposition of zinc and iron (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 1060-1063 
    Details
    ISSN: 1420-9071
    Schlagwort(e): LEC rat ; copper ; metallothionein ; ceruloplasmin ; zinc ; iron
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The Cu concentration was about 40 times higher in the liver of LEC (Long-Evans with a cinnamon-like coat color) rats aged 77 days (227.5±21.6 μg/g liver) than in Fischer rats (5.2±0.1 μg/g liver). However, in the kidney and brain of the LEC rats, Cu concentrations were lower than in these organs of the Fischer rats. Cu concentration in the hepatic metallothionein fraction was about 130 times higher in the LEC rats than in the Fischer rats. The LEC rats showed markedly low concentrations of Cu in the serum and bile. It seems likely that excretion of Cu from the liver into the bile and blood (as ceruloplasmin) is inherently lacking in the LEC rat.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01923342
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  • 8
    Digitale Medien
    Digitale Medien
    Effects of plant lectins on cellular defense reactions of ascidian hemocytes (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 839-842 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Lectin ; ascidian hemocyte ; hemocyte aggregation ; phagocytosis ; allogenic reaction ; Halocynthia roretzi
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The effects of plant lectins on the three cellular defense reactions of hemocytes of the solitary ascidian,Halocynthia roretzi (hemocyte aggregation, phagocytosis, and an allogenic reaction), were investigated. Concanavalin A inhibited aggregation, while wheat germ agglutinin and ricin inhibited the allogenic reaction. Neither of the lectins showed inhibitory effects on phagocytosis, but ricin promoted phagocytosis. These effects of the lectins were diminished by the addition of sugars specific for the respective lectins. These results strongly suggest that different surface carbohydrates are involved in the recognition mechanisms of threeH. roretzi cellular defense reactions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01924000
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  • 9
    Digitale Medien
    Digitale Medien
    Ultrasonic comparison of two morphologically distinct melanosomes in malignant melanomas (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 571-572 
    Details
    ISSN: 1420-9071
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Ultrasonic measurement (0.333–200 MHz) of melanosomes isolated from B16 and Harding Passey (HP) mouse melanomas indicates that the partial wave resonance and principal relaxation of the 2 kinds of melanosomes are similar, but that their stochastic resonance is markedly different. The structure of the melanosomes appears basically amorphous, but linearly ordered and copolymeric in the molecular dimension of a segment composed of 5–6 zigzag units, which are packed closely in B16 and more openly in HP.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01982336
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  • 10
    Digitale Medien
    Digitale Medien
    Quantitative immunofluorescence of tyrosine hydroxylase in the adrenal medulla of spontaneously hypertensive rats (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1054-1055 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Quantitative immunofluorescence ; tyrosine hydroxylase ; adrenal medulla ; SHR
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The amount of tyrosine hydroxylase protein in the adrenal medulla, which was estimated by a quantitative immunofluorescence method, was higher in spontaneously hypertensive rats than in normotensive control Wistar-Kyoto rats at 4 and 16 weeks of age before and after the development of hypertension.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01952140
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