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  • 1
    Electronic Resource
    Electronic Resource
    REGULATION OF NUCLEAR LOCALIZATION: A Key to a Door (1999)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Cell and Developmental Biology 15 (1999), S. 291-339 
    Details
    ISSN: 1081-0706
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Information can be transferred between the nucleus and the cytoplasm by translocating macromolecules across the nuclear envelope. Communication of extracellular or intracellular changes to the nucleus frequently leads to a transcriptional response that allows cells to survive in a continuously changing environment. Eukaryotic cells have evolved ways to regulate this movement of macromolecules between the cytoplasm and the nucleus such that the transfer of information occurs only under conditions in which a transcriptional response is required. This review focuses on the ways in which cells regulate movement of proteins across the nuclear envelope and the significance of this regulation for controlling diverse biological processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.cellbio.15.1.291
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    NEW PERSPECTIVES ON NUCLEAR TRANSPORT (2001)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 35 (2001), S. 341-364 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract A central aspect of cellular function is the proper regulation of nucleocytoplasmic transport. In recent years, significant progress has been made in identifying and characterizing the essential components of the transport machinery. Despite these advances, some facets of this process are still unclear. Furthermore, recent work has uncovered novel molecules and mechanisms of nuclear transport. This review focuses on the unresolved and novel aspects of nuclear transport and explores issues in tRNA, snRNA, and mRNA export that highlight the diversity of nuclear transport mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.genet.35.102401.090720
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    Paper (German National Licenses)
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  • 3
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    Living with Noisy Genes: How Cells Function Reliably with Inherent Variability in Gene Expression (2007)
    Annual Reviews
    Details
    Publication Date: 2007-06-01
    Print ISSN: 1056-8700
    Electronic ISSN: 1545-4266
    Topics: Biology , Physics
    Published by Annual Reviews
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  • 4
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    Genome-Wide Characterization of the Phosphate Starvation Response in Schizosaccharomyces pombe (2012)
    BioMed Central
    Details
    Publication Date: 2012-12-01
    Description: Background Inorganic phosphate is an essential nutrient required by organisms for growth. During phosphate starvation, Saccharomyces cerevisiae activates the phosphate signal transduction (PHO) pathway, leading to expression of the secreted acid phosphatase, PHO5. The fission yeast, Schizosaccharomyces pombe, regulates expression of the ScPHO5 homolog (pho1 + ) via a non-orthologous PHO pathway involving genetically identified positive (pho7 + ) and negative (csk1 +) regulators. The genes induced by phosphate limitation and the molecular mechanism by which pho7 + and csk1 + function are unknown. Here we use a combination of molecular biology, expression microarrays, and chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) to characterize the role of pho7 + and csk1 + in the PHO response. Results We define the set of genes that comprise the initial response to phosphate starvation in S. pombe. We identify a conserved PHO response that contains the ScPHO5 (pho1 + ), ScPHO84 (SPBC8E4.01c), and ScGIT1 (SPBC1271.09) orthologs. We identify members of the Pho7 regulon and characterize Pho7 binding in response to phosphate-limitation and Csk1 activity. We demonstrate that activation of pho1 + requires Pho7 binding to a UAS in the pho1 + promoter and that Csk1 repression does not regulate Pho7 enrichment. Further, we find that Pho7-dependent activation is not limited to phosphate-starvation, as additional environmental stress response pathways require pho7 + for maximal induction. Conclusions We provide a global analysis of the transcriptional response to phosphate limitation in S. pombe. Our results elucidate the conserved core regulon induced in response to phosphate starvation in this ascomycete distantly related to S. cerevisiae and provide a better understanding of flexibility in environmental stress response networks.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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    PAPER CURRENT
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