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Electronic Resource

Least-Cost Climatic Stabilization (1991)

Lovins, A B ; Lovins, L H

Palo Alto, Calif. : Annual Reviews

Annual Review of Environment and Resources 16 (1991), S. 433-531

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ISSN: 1056-3466

Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Topics: Energy, Environment Protection, Nuclear Power Engineering

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1146/annurev.eg.16.110191.002245

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Least-Cost Climatic Stabilization (1991)

Lovins, A B ; Lovins, L H

Annual Reviews

In: Annual Review of Energy and the Environment. 1991; 16(1): 433-531. Published 1991 Nov 01. doi: 10.1146/annurev.eg.16.110191.002245.

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Publication Date: 1991-11-01

Print ISSN: 1056-3466

Topics: Energy, Environment Protection, Nuclear Power Engineering

Published by Annual Reviews

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Factor 4 : duplicar el bienestar con la mitad de los recursos naturales (1997)

Weizsäcker, Ernst U. von ; Lovins, Amory B. ; Lovins, L. Hunter

Barcelona : Galaxia Gutenberg | Wuppertal : Wuppertal Institut für Klima, Umwelt, Energie

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Publication Date: 2018-11-19

Keywords: ddc:600

Repository Name: Wuppertal Institut für Klima, Umwelt, Energie

Language: Spanish

Type: book , doc-type:book

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Electronic Resource

Soft Energy Technologies (1978)

Lovins, A B

Palo Alto, Calif. : Annual Reviews

Annual Review of Environment and Resources 3 (1978), S. 477-517

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ISSN: 0362-1626

Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Topics: Energy, Environment Protection, Nuclear Power Engineering

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1146/annurev.eg.03.110178.002401

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Antigens of human trophoblasts: A working hypothesis for their role in normal and abnormal pregnancies (1978)

Faulk, W. P. ; Temple, A. ; Lovins, R. E. ; [et al.]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 1978; 75(4): 1947-1951. Published 1978 Apr 01. doi: 10.1073/pnas.75.4.1947.

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Publication Date: 1978-04-01

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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The Mycobacterium marinum ESX-1 system mediates phagosomal permeabilization and type I interferon production via separable mechanisms (2019)

Lienard, Julia ; Nobs, Esther ; Lovins, Victoria ; [et al.]

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences of the United States of America. 2019; 117(2): 1160-1166. Published 2019 Dec 26. doi: 10.1073/pnas.1911646117.

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Publication Date: 2019-12-26

Description: Following mycobacterial entry into macrophages the ESX-1 type VII secretion system promotes phagosomal permeabilization and type I IFN production, key features of tuberculosis pathogenesis. The current model states that the secreted substrate ESAT-6 is required for membrane permeabilization and that a subsequent passive leakage of extracellular bacterial DNA into the host cell cytosol is sensed by the cyclic GMP-AMP synthase (cGAS) and stimulator of IFN genes (STING) pathway to induce type I IFN production. We employed a collection of Mycobacterium marinum ESX-1 transposon mutants in a macrophage infection model and show that permeabilization of the phagosomal membrane does not require ESAT-6 secretion. Moreover, loss of membrane integrity is insufficient to induce type I IFN production. Instead, type I IFN production requires intact ESX-1 function and correlates with release of mitochondrial and nuclear host DNA into the cytosol, indicating that ESX-1 affects host membrane integrity and DNA release via genetically separable mechanisms. These results suggest a revised model for major aspects of ESX-1–mediated host interactions and put focus on elucidating the mechanisms by which ESX-1 permeabilizes host membranes and induces the type I IFN response, questions of importance for our basic understanding of mycobacterial pathogenesis and innate immune sensing.

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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