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  • Articles  (6)
  • 93B27  (3)
  • chemical modification  (3)
  • Springer  (6)
  • American Society of Hematology
  • Springer Nature
  • 1
    Electronic Resource
    Electronic Resource
    The functional involvement of Lys-38 in the heavy subunit of rat kidney γ-glutamylcysteine synthetase: Chemical modification and mutagenesis studies (1996)
    Springer
    The protein journal 15 (1996), S. 321-326 
    Details
    ISSN: 1573-4943
    Keywords: γ-glutamylcysteine synthetase ; functional role of lysine ; chemical modification ; site-directed mutagenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Rat kidneyγ-glutamylcysteine synthetase (γGCS) was inactivated by reaction with trinitrobenzene sulfonate (TNBS), and the reaction followed pseudo-first-order kinetics. Inactivation kinetics revealed that only one of the amino acid residues modified by TNBS was essential for-γGCS activity. The addition of 10 mM Mg2+ to the TNBS inactivation reaction resulted in a 16-fold increase in the rate of inactivation. Chromatographic analysis on the tryptic hydrolyzates of trinitrophenylated (TNP) derivatives showed that Lys-38 in theγGCS heavy subunit was significantly modified in the presence of Mg2+. In contrast to small changes in the catalytic properties observed by mutation of Lys-38 to Arg, the mutants K38N and K38E had a marked decrease in enzymatic activity and about twofold increase inK m for glutamate. These results suggest that the positively charged Lys-38 may sbe involved in the binding of glutamate toγGCS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01887121
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  • 2
    Electronic Resource
    Electronic Resource
    Chemical modification of tryptophan residues in α-neurotoxins fromOphiophagus hannah (king cobra) venom (1995)
    Springer
    The protein journal 14 (1995), S. 89-94 
    Details
    ISSN: 1573-4943
    Keywords: King cobraα-neurotoxins ; tryptophan residues ; chemical modification ; nicotinic acetylcholine receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Twoα-neurotoxins, Oh-4 and Oh-7, from the king cobra (Ophiophagus hannah) venom were subjected to Trp modification with 2-nitrophenylsulfenyl chloride (NPS-Cl). One major NPS derivative was isolated from the modified mixtures of Oh-4 and two from Oh-7 by HPLC. Amino acid analysis and sequence determination revealed that Trp-27 in Oh-4, and Trp-30 and Trp-26 and 30 in the two Oh-7 derivatives, were modified, respectively. Sulfenylation of Trp-27 in Oh-4 caused about 70% drop in lethal toxicity and nicotinic acetylcholine receptor-binding activity. Modification of Trp-30 in Oh-7 resulted in the decrease of lethal toxicity by 36% and binding activity by 61%. The activities were further lost when the conserved Trp-26 in Oh-7 was modified. Sulfenylation of the Trp residues did not significantly affect the secondary structure of the toxins as revealed by the CD spectra. These results indicate that the Trp residues in these two longα-neurotoxins may be involved in the receptor binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01888366
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  • 3
    Electronic Resource
    Electronic Resource
    Chemical modification of cationic residues in toxin a from king cobra (Ophiophagus hannah) venom (1996)
    Springer
    The protein journal 15 (1996), S. 95-101 
    Details
    ISSN: 1573-4943
    Keywords: Cationic residues ; chemical modification ; nicotinic acetylcholine receptor ; Toxin a
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The cationic groups of arginine and lysine residues inα-neurotoxin, Toxin a, isolated from king cobra (Ophiophagus hannah) venom were subjected to modification with trinitrobenzene sulfonate (TNBS) andp-hydroxyphenylglyoxal (HPG), respectively. The trinitrophenylated (TNP) derivatives of Toxin a at Lys-10, 56, or 71 showed approximately 25% residual lethality, and modifications on Lys-10 and 56 or Lys-10 and 50 resulted in a decrease of lethality by 84% and 86%, respectively. Modifications on Arg-34, 37, and 70 and Arg-34, 37, and 72 in Toxin a caused a decrease in lethality by 92% and 93%, respectively, and it almost completely lost its lethality and binding activity to nicotinic acetylcholine receptor (nAChR) when all four arginine residues were modified. These results indicate that in addition to the cationic residues on loop II (Arg-34, 37), loop III (Lys-50, 56), and the C-terminal tail (Arg-70, 72; Lys-71), Lys-10 on loop I is also related to the neurotoxicity of Toxin a.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01886815
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  • 4
    Electronic Resource
    Electronic Resource
    Controllability of a class of hybrid dynamic systems (III)—Multiple time-delay case (2003)
    Springer
    Applied mathematics and mechanics 24 (2003), S. 1063-1074 
    Details
    ISSN: 1573-2754
    Keywords: hybrid dynamic system ; switched linear system ; time-delay ; controllability ; controllable set ; switching sequence ; switching path ; TP13 ; TP273 ; O317 ; 93B05 ; 93B27 ; 93C99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract The controllability for switched linear systems with time-delay in controls is first investigated. The whole work contains three parts. This is the third part. The definition and determination of controllability of switched linear systems with multiple time-delay in control functions is mainly investigated. The sufficient and necessary conditions for the one-periodic, multiple-periodic controllability of periodic-type systems and controllability of aperiodic systems are presented, respectively. Finally, the case of distinct delays is discussed, it is shown that the controllability is independent of the size of delays.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02437638
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  • 5
    Electronic Resource
    Electronic Resource
    Controllability of a class of hybrid dynamic systems (II)—Single time-delay case (2003)
    Springer
    Applied mathematics and mechanics 24 (2003), S. 1051-1062 
    Details
    ISSN: 1573-2754
    Keywords: hybrid dynamic system ; switched linear system ; time-delay ; controllability ; controllable set ; switching sequence ; switching path ; TP13 ; TP273 ; O317 ; 93B05 ; 93B27 ; 93C99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract The controllability for switched linear systems with time-delay in controls is first investigated. The whole work contains three parts. This is the second part. The definition and determination of controllability of switched linear systems with single time-delay in control functions is mainly investigated. The sufficient and necessary conditions for the oneperiodic, multiple-periodic controllability of periodic-type systems and controllability of periodic systems are presented, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02437637
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  • 6
    Electronic Resource
    Electronic Resource
    Controllability of a class of hybrid dynamic systems (I)—Basic properties and preliminary results (2003)
    Springer
    Applied mathematics and mechanics 24 (2003), S. 1041-1050 
    Details
    ISSN: 1573-2754
    Keywords: hybrid dynamic system ; switched linear system ; time-delay ; controllability ; generalized cyclic invariant subspace ; switching sequence ; switching path ; TP13 ; TP273 ; O317 ; 93B05 ; 93B27 ; 93C99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Mathematics , Physics
    Notes: Abstract The controllability for switched linear system with time-delay in controls was first investigated. The whole work contains three parts. This is the first part, including problem formulation and some preliminaries. Firstly, the mathematical model of switched linear systems with time-delay in control functions was presented. Secondly, the concept of column space, cyclic invariant subspace and generalized cyclic invariant subspace were introduced. And some basic properties, such as separation lemma, were presented. Finally, a basic lemma was given to reveal the relation between the solution set of a centain integral equations and the generalized cyclic invariant subspace. This lemma will play an important role in the determination of controllability. All these definitions and lemmas are necessary research tools for controllability analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02437636
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