ALBERT

Description: Many soil regulating ecosystem services (ES) are linked to Earth’s atmosphere, but associated monetary values often are unknown or difficult to quantify. Atmospheric deposition of calcium (Ca2+) and magnesium (Mg2+) are abiotic flows (wet, dry, and total) from the atmosphere to land surfaces, which potentially can become available to sequester carbon (C) as soil inorganic carbon (SIC). However, these processes typically have not been included in economic valuations of ecosystem services. The primary objective of this study was to demonstrate an approach for valuing non-constrained potential SIC sequestration from atmospheric Ca2+ and Mg2+ deposition based on the concept of the avoided social cost of carbon dioxide emissions (SC-CO2). Maximum monetary values associated with the non-constrained potential SIC sequestration were compiled for the contiguous United States (U.S.) by soil order, land resource region (LRR), state, and region using available deposition data from the National Atmospheric Deposition Program (NRSP-3). For the entire contiguous U.S., an average annual monetary value for the non-constrained potential SIC sequestration due to atmospheric Ca2+ and Mg2+ deposition was $135M (i.e., $135 million U.S. dollars, where M = million = 106). Mollisols, Alfisols, and Entisols were soil orders with the highest average annual monetary values for non-constrained potential SIC sequestration. When normalized by land area, however, Vertisols had the highest average annual monetary values followed by Alfisols and Mollisols for non-constrained potential SIC sequestration. From a more agricultural perspective, the LRRs with the highest average annual monetary values for non-constrained potential SIC sequestration were the Western Range and Irrigated Region (D), the Central Feed Grains and Livestock Region (M), and the Central Great Plains Winter Wheat and Range Region (H). When normalized by area, the LRRS with the highest average annual monetary values were the Southwest Plateaus and Plains Range and Cotton Region (I) and the Florida Subtropical Fruit, Truck Crop and Range Region (U). Among the U.S. states, the highest average annual monetary values for non-constrained potential SIC sequestration were Texas, Kansas, and New Mexico, but when normalized by area the highest values by state were Kansas, Iowa, and Texas. Geographical regions in the contiguous U.S. with the highest average annual monetary values for non-constrained potential SIC sequestration were the South Central, Midwest, and West; when normalized by area, the highest values by region were South Central, Midwest, and Northern Plains. Constraints on maximum monetary values, based on physical, chemical, biological, economic, social, and political limitations, need to be considered and quantified to obtain more precise and accurate accounting of the ES associated with SIC sequestration due to atmospheric Ca2+ and Mg2+ deposition.

Description: Introduction The presence of the CD157 GPI-protein on both monocytes and granulocytes only gives opportunity to use it as a target for paroxysmal nocturnal hemoglobinuria (PNH) phenotype cells detection instead of CD24 and CD14, thus improving the technique of PNH-cells evaluation. In present study we used standard technique (International Clinical Cytometry Society (ICCS) guideline proposal) together with 5 color combination of mAbs for detection of PNH-clone on the monocytes and granulocytes simultaneously in one test-tube. Objectives: improvement of PNH cells detection technique. Materials and methods: Blood samples were collected from 37 patients (pts) with bone marrow failure syndrome (aplastic anemia – 34 pts., PNH - 2 pts., myelodysplastic syndrome – 1 pt.; 23 female and 14 men; median age 24 (15 to 66). PNH clone was detected by flow cytometry in all 37 pts. Three healthy donors were in control group. The comparison of the standard 4-color technique of PNH clone size detection on monocytes (FLAER, CD14, CD64, CD45 reagents) and on granulocytes (FLAER, CD24, CD15, CD45 reagents) with the 5-color technique using CD157 GPI-protein antibodies for the both cells populations in one test-tube (FLAER, CD157, CD15, CD64, CD45) were performed. Results: Both methods showed the same high sensitivity for determining of PNH clone. The correlation coefficient was 0,9994 for granulocytes and 0,9924 for monocytes (Figure 1). Figure 1 Figure 1. In group of patients with minor PNH-clone (range from 0,01% to 0,99%) the clone size was twice times bigger on monocytes compared to granulocytes using the standard method, whereas with antibodies against CD157 this difference disappeared. In patients with PNH-clone between 1% and 10% the clone was nearly three times less on granulocytes than monocytes using both methods; in the group with clone more than 10% there was no differences between cells populations. Table 1. Average value of PNH clone on leukocytes in groups of patients both techniques PNH clone Gr, % (mean) Mon, % (mean) CD24-/FLAER- CD157-/FLAER- CD14-/FLAER- CD157-/FLAER- 0%-0,99% 0,178 0,349 0,323 0,378 1%-9,99% 3,98 3,76 9,54 9,98 〉10% 71,52 71,52 71,85 71,34 Conclusion: The results of the PNH clone detection obtained with CD157 mAbs are comparable with the standard technique proposed by ISSC. However, the use of CD157 antibodies has important advantage: the PNH clone size detection in one test-tube with 5-color combination reduces time and expenses. Additionally, using of 5-color CD157 antibodies kit would be preferable for the monitoring and detection of minor PNH clone. Disclosures No relevant conflicts of interest to declare.

Description: Pregnancy and childbirth associated with a high risk of severe maternal and fetal complications in women with paroxysmal nocturnal hemoglobinuria (PNH). Recently the management of PNH during pregnancy has been challenging and childbearing was practically contraindicated in these patients. Eculizumab treatment improved the prognosis in PNH and made it possible to minimize complications during pregnancy. Establishment of effective and safe algorithms for the management of pregnancy, delivery and postpartum period in PNH patients is crucial to their lives. Since 1999, we have analyzed 15 pregnancies in six women with PNH. The median age at PNH diagnosis was 22 years (18-27), the median age at the start of pregnancy - 25 years (21-34). All of them were diagnosed with PNH following treatment for aplastic anemia (AA) with antithymocyte globulin, cyclosporine A and splenectomy in two cases before pregnancy. The median of PNH granulocyte clone at the start of pregnancy was 74,7% (17,8-94,1). Pregnancy occurred during complete remission of AA with PNH clinical signs in 5 (33,3%) cases. Most patients were in partial remission at the time of pregnancy-7 (46,7%) or continued to receive immunosuppressive therapy with minimal effect-3 (20%). Progression of aplasia observed during 4 (26,7%) pregnancies, but it was not severe and special treatment delayed until the completion of pregnancy. Two patients exposed to eculizumab before conceiving and remained on the treatment during pregnancy. Other women received only symptomatic therapy. Anticoagulation with low molecular weight heparin was used in 5 (33,3%) pregnancies. No thrombotic events during pregnancy and postpartum have been observed. Skin hemorrhages were revealed in 2 (13,3%) patients. During 4 (26,7%) gestations patients underwent erythrocytes and/or platelets transfusion. Pregnancies resulted in the birth of healthy infants in 7 (46,7%) cases - two girls and five boys. There were no adverse effects in the newborns from PNH patients both on eculizumab and without it. Successful outcomes were in 2/2 pregnancies on eculizumab treatment and in 5/13 (38,5%) cases without the drug. Caesarean sections were performed in all of births, early surgical delivery (30-34 weeks)-in 4/7 cases (preeclampsia-2, placenta previa-1, breakthrough hemolysis-1). Adverse pregnancy outcomes occurred only in patients not receiving eculizumab and amounted to 8/13 (61,5%). Only three patients had planned the pregnancy, other 12 cases were unplanned. Consequently, in 4 (30,8%) cases of pregnancy in the midst of illness was performed the abortion for medical reasons. Spontaneous miscarriage was registered in 2 (15,4%) patients. Two pregnancies (15,4%) ended in fetal death on 27th and 20th gestation weeks. Transfusion requirements increased in two pregnancies with symptomatic therapy, but did not increase on eculizumab. One of patients had first pregnancy without eculizumab and developed complications such as preeclampsia, postpartum severe epistaxis and high transfusion requirement (an average of 1,2 units per month). During second pregnancy on eculizumab she had no obstetric complications and transfusion requirements were less (0,5 units monthly). Second patient continued to have evidence of intravascular hemolysis despite the treatment, and so received eculizumab more frequent (one time in 10 days) in the third trimester. PNH granulocyte clone size decreased in both cases of eculizumab treatment during pregnancy. The risk of complications in PNH patients during pregnancy may be minimized by applying the management algorithm with eculizumab treatment. Despite the small number of observations, we can safely conclude that pregnancy outcomes in PNH patients with eculizumab are better than with only symptomatic therapy. Our experience confirms that eculizumab can be safely used in PNH throughout pregnancy to reduce the risk of complications and adverse outcomes. There is no difference in health between infants born by mothers with PNH and the newborns from general population. Disclosures No relevant conflicts of interest to declare.

Description: Abstract 1879 Splenectomy in patients with MDS is a treatment option that is beeing applied very rare [Steensma D., et al, Leuk Res.,2003; Bourgeosis E., et al, Leukemia, 2001]. There are anecdotal reports with very few patients demonstrating its efficacy. In most cases splenectomy was indicated for MDS patients with immune related thrombocytopenia. Here we would like to report the results of 33 splenectomies in patients with MDS who have been treated in our Center during 1994–2010. Within this period of follow-up totally 155 patients were diagnosed with different forms of MDS, 35% of them presenting with hypoplasia. The MDS treatment algorithm in our Center incorporates splenectomy as one of the options for pts with hypoplastic forms of MDS with bone marrow blast count less than 10%, refractory to initial cyclosporin A treatment or refractory to transfusions. Among patients who were splenectomised there were 20 females, 13 males with a median age of 40 years (range 18–74). Median time from diagnosis to splenectomy was 12 months (range 4–107). By WHO-classification there were 2 patients with RA, 22 – with RCMD, 2 – with MDS and del (5q), 6 - with RAEB, 1 - with AML after MDS. Cytogenetic analysis was available in 32 cases, and karyotype was normal in 15 patients (47%).The most common abnormalities were: del (5q) - 3, del (20q) - 2, trisomy 8 - 2, tetrasomy 8 - 1, monosomy 7 - 2, complex karyotype - 4. Bone marrow biopsy revealed hypoplasia in 25 patients (75%), myelofibrosis – in 7 (21%). The median WBC count was 2,6*109/L (range 0,6-8,7), hemoglobin 6,9 g/dL (47-119) and platelets 26*109/L (6-170). 27 pts (82%) were RBC transfusion dependent, 22 (67%) - platelets transfusion dependent. 13 pts had received immunosuppression therapy (ATG, cyclosporine A) before splenectomy, 2 - cytotoxic chemotherapy, 3 - decitabine. The majority of splenectomies were done by laparoscopic method - 26 (79%), in one case the convertion was done. In all cases we performed liver biopsy. Postoperative complications (hemorrhage) occurred in 1 patient but there were no deaths due to operation. One death occurred in 7 days after splenectomy due to fulminant progression to AML. Median spleen weight was 180 gms (range 70–930). Median intraoperative blood loss was 250 ml (range 50–9350). Histology was available in 30 patients. Extramedullary hematopoesis was revealed in 3 cases (10%), blast infiltration - in 2 (7%), massive lymphoid infiltration was detected in 5 cases and in one patient in was proved to be clonal (marginal zone lymphoma, MZL). Hemosiderin depositions in the macrophages were seen in half of the cases -16 (53%). One case was characterized by granulomatosis in spleen and liver with negative immunohistohemical staining to Mycobacteria tuberculosis. Splenectomy lead to sustained improvement of cytopenias in 16 cases (48%): decreased transfusion dependence in 14 (42%) and transfusion independence in 2 (6%). After splenectomy 5 patients were followed by “wait and see” approach, 17 continued with immunosuppressive therapy (ATG,CyA), 3 patients were treated with cytotoxic chemotherapy, 1 – with decytabine, 2 received EPO, 1- danazol, 2 - iron chelation therapy, 2 – only transfusions therapy. We did not noticed the infections rate augmentation after splenectomy. Transformation to AML was registered 6 (18%) at median 6 months (0,3 -9). 13 splenectomized patients (39%) died at a median 12 months (range 0,3-84) and the main death reasons were: AML progression, aplasia deterioration followed by infections and hemorrhage. 20 patients are alive with a median follow-up after splenectomy 33 months (2-108). Analysis of our 15-years study data give us a confidence to conclude that splenectomy still may be an adequate option for distinct forms of MDS (hypoplastic forms with bone marrow blast count less than 10%, refractory to initial immunosupressive treatment or refractory to transfusions), producing cytopenia improvement in half of the patients with decreasing transfusion dependance also in half of the patients, sometimes bringing a clear diagnosis (MZL). The mechanism of action is not very clear but we can speculate that splenectomy removes the “cell-destroying” organ, deminishes immune pathways of cytopenias due to large lymphoid compartment deletion, provides the resustainment of sensitivity to immunosupressive agents. Disclosures: No relevant conflicts of interest to declare.

Description: Total soil carbon (TSC) is a composite (total) stock, which is the sum of soil organic carbon (SOC) and soil inorganic carbon (SIC). Total soil carbon, and its individual two components, are all important criteria for assessing ecosytems services (ES) and for achieving United Nations (UN) Sustainable Development Goals (SDGs). The objective of this study was to assess the value of TSC stocks, based on the concept of the avoided social cost of carbon dioxide emissions, for the contiguous United States (U.S.) by soil order, soil depth (0–20, 20–100, 100–200 cm), land resource region (LRR), state, and region using information from the State Soil Geographic (STATSGO) database. The total calculated monetary value for TSC storage in the contiguous U.S. was between $8.13T (i.e., $8.13 trillion U.S. dollars, where T = trillion = 1012) and $37.5T, with a midpoint value of $21.1T. Soil orders with the highest TSC storage midpoint values were Mollisols ($7.78T) and Aridisols ($2.49T). Based on area, however, the soil orders with highest midpoint TSC values were Histosols ($21.95 m−2) and Vertisols ($5.84 m−2). Soil depth was important, with the highest values of TSC storage being found in the interval 20–100 cm ($9.87T—total midpoint value, and $1.34 m−2—midpoint area density). The soil depth interval 0–20 cm had the lowest TSC storage ($4.30T) and lowest area-density ($0.58 m−2) value, which exemplifies the prominence of TSC in the deeper subsurface layers of soil. The LRRs with the highest midpoint TSC storage values were: M—Central Feed Grains and Livestock Region ($2.82T) and D—Western Range and Irrigated Region ($2.64T), whereas on an area basis the LRRs with the highest values were I—Southwest Plateaus and Plains Range and Cotton Region ($6.90 m−2) and J—Southwestern Prairies Cotton and Forage Region ($6.38 m−2). Among the U.S. states, the highest midpoint TSC storage values were Texas ($4.03T) and Minnesota ($1.29T), while based on area this order was reversed (i.e., Minnesota: $6.16 m−2; Texas: $6.10 m−2). Comprehensive assessment of regulating ES requires TSC, which is an important measure in achieving the UN SDGs. Despite the known shortcomings of soil databases, such as their static nature and the wide ranges of uncertainty reported for various soil properties, they provide the most comprehensive information available at this time for making systematic assessments of ecosystem services at large spatial scales.

Description: Soil organic carbon (SOC) generates several ecosystem services (ES), including a regulating service by sequestering carbon (C) as SOC. This ES can be valued based on the avoided social cost of carbon (SC-CO2) from the long-term damage resulting from emissions of carbon dioxide (CO2). The objective of this study was to assess the value of SOC stocks, based on the avoided SC-CO2 ($42 per metric ton of CO2 in 2007 U.S. dollars), in the contiguous United States (U.S.) by soil order, soil depth (0–20, 20–100, 100–200 cm), land resource region (LRR), state, and region using information from the State Soil Geographic (STATSGO) database. The total calculated monetary value for SOC storage in the contiguous U.S. was between $4.64T (i.e., $4.64 trillion U.S. dollars, where T = trillion = 1012) and $23.1T, with a midpoint value of $12.7T. Soil orders with the highest midpoint SOC storage values were 1): Mollisols ($4.21T), 2) Histosols ($2.31T), and 3) Alfisols ($1.48T). The midpoint values of SOC normalized by area within soil order boundaries were ranked: 1) Histosols ($21.58 m−2), 2) Vertisols ($2.26 m−2), and 3) Mollisols ($2.08 m−2). The soil depth interval with the highest midpoint values of SOC storage and content was 20–100 cm ($6.18T and $0.84 m−2, respectively), while the depth interval 100–200 cm had the lowest midpoint values of SOC storage ($2.88T) and content ($0.39 m−2). The depth trends exemplify the prominence of SOC in the upper portions of soil. The LRRs with the highest midpoint SOC storage values were: 1) M – Central Feed Grains and Livestock Region ($1.8T), 2) T – Atlantic and Gulf Coast Lowland Forest and Crop Region ($1.26T), and 3) K – Northern Lake States Forest and Forage Region ($1.16T). The midpoint values of SOC normalized by area within LRR boundaries were ranked: 1) U – Florida Subtropical Fruit, Truck Crop, and Range Region ($6.10 m−2), 2) T – Atlantic and Gulf Coast Lowland Forest and Crop Region ($5.44 m−2), and 3) K – Northern Lake States Forest and Forage Region ($3.88 m−2). States with the highest midpoint values of SOC storage were: 1) Texas ($1.08T), 2) Minnesota ($834B) (i.e., $834 billion U.S. dollars, where B = billion = 109), and 3) Florida ($742B). Midpoint values of SOC normalized by area within state boundaries were ranked: 1) Florida ($5.44 m−2), 2) Delaware ($4.10 m−2), and 3) Minnesota ($3.99 m−2). Regions with the highest midpoint values of SOC storage were: 1) Midwest ($3.17T), 2) Southeast ($2.44T), and 3) Northern Plains ($2.35T). Midpoint values of SOC normalized by area within region boundaries were ranked: 1) Midwest ($2.73 m−2), 2) Southeast ($2.31 m−2), and 3) East ($1.82 m−2). The reported values and trends demonstrate the need for policies with regards to SOC management, which requires incentives within administrative boundaries but informed by the geographic distribution of SOC.

Description: Ecosystem services (ESs) are increasingly being used by many countries around the world as a framework for addressing the United Nations (UN) Sustainable Development Goals (SDGs). This review article of the usability of Libyan soil databases for ESs and SDGs is the first of its kind for North Africa. The objectives of the article are to: describe the available soil resources of Libya in relation to an ES framework; provide examples of the usability of Libyan soil databases for ES applications (e.g., provisioning, Healthy Eating Plate), and describe some of the typical disservices in the country. Desertification, salinization, and limited freshwater resources are the largest challenges (disservices) for agriculture and future development in Libya. Seawater intrusion in coastal areas due to rising sea levels has resulted in high concentrations of salts in irrigation waters, which can lead to low soil productivity. These challenges can be addressed by integrating Libyan soil resources into a market that transforms resources into goods and services to meet human demand in a sustainable manner, with non-market institutions mediating the interactions between humans and the environment. If Libyan soil resources are taken into account by both market and non-market institutions, it will lead to more efficient use of soil resources and also should enable the implementation of innovative strategies, such as integrated farming systems, non-soil-based agricultural production (e.g., hydroponics), and alternative farming practices.

Description: Soil databases are very important for assessing ecosystem services at different administrative levels (e.g., state, region etc.). Soil databases provide information about numerous soil properties, including soil inorganic carbon (SIC), which is a naturally occurring liming material that regulates soil pH and performs other key functions related to all four recognized ecosystem services (e.g., provisioning, regulating, cultural and supporting services). However, the ecosystem services value, or “true value,” of SIC is not recognized in the current land market. In this case, a negative externality arises because SIC with a positive value has zero market price, resulting in the market failure and the inefficient use of land. One potential method to assess the value of SIC is by determining its replacement cost based on the price of commercial limestone that would be required to amend soil. The objective of this study is to assess SIC replacement cost value in the contiguous United States (U.S.) by depth (0–20, 20–100, 100–200 cm) and considering different spatial aggregation levels (i.e., state, region, land resource region (LRR) using the State Soil Geographic (STATSGO) soil database. A replacement cost value of SIC was determined based on an average price of limestone in 2014 ($10.42 per U.S. ton). Within the contiguous U.S., the total replacement cost value of SIC in the upper two meters of soil is between $2.16T (i.e., 2.16 trillion U.S. dollars, where T = trillion = 1012) and $8.97T. States with the highest midpoint total value of SIC were: (1) Texas ($1.84T), (2) New Mexico ($355B, that is, 355 billion U.S. dollars, where B = billion = 109) and (3) Montana ($325B). When normalized by area, the states with the highest midpoint SIC values were: (1) Texas ($2.78 m−2), (2) Utah ($1.72 m−2) and (3) Minnesota ($1.35 m−2). The highest ranked regions for total SIC value were: (1) South Central ($1.95T), (2) West ($1.23T) and (3) Northern Plains ($1.01T), while the highest ranked regions based on area-normalized SIC value were: (1) South Central ($1.80 m−2), (2) Midwest ($0.82 m−2) and (3) West ($0.63 m−2). For land resource regions (LRR), the rankings were: (1) Western Range and Irrigated Region ($1.10T), (2) Central Great Plains Winter Wheat and Range Region ($926B) and (3) Central Feed Grains and Livestock Region ($635B) based on total SIC value, while the LRR rankings based on area-normalized SIC value were: (1) Southwest Plateaus and Plains Range and Cotton Region ($3.33 m−2), (2) Southwestern Prairies Cotton and Forage Region ($2.83 m−2) and (3) Central Great Plains Winter Wheat and Range Region ($1.59 m−2). Most of the SIC is located within the 100–200 cm depth interval with a midpoint replacement cost value of $2.49T and an area-normalized value of $0.34 m−2. Results from this study provide a link between science-based estimates (e.g., soil order) of SIC replacement costs within the administrative boundaries (e.g., state, region etc.).

Description: Island ecosystems are particularly susceptible to climate change and human activities. The change of land use and land cover (LULC) has considerable impacts on island ecosystems, and there is a critical need for a free and open-source tool for detecting land cover fluctuations and spatial distribution. This study used Google Earth Engine (GEE) to explore land cover classification and the spatial pattern of major land cover change from 1990 to 2019 on Haitan Island, China. The land cover classification was performed using multiple spectral bands (RGB, NIR, SWIR), vegetation indices (NDVI, NDBI, MNDWI), and tasseled cap transformation of Landsat images based on the random forest supervised algorithm. The major land cover conversion processes (transfer to and from) between 1990 and 2019 were analyzed in detail for the years of 1990, 2000, 2007, and 2019, and the overall accuracies ranged from 88.43% to 91.08%, while the Kappa coefficients varied from 0.86 to 0.90. During 1990–2019, other land, cultivated land, sandy land, and water area decreased by 30.70%, 13.63%, 3.76%, and 0.95%, respectively, while forest and built-up land increased by 30.94% and 16.20% of the study area, respectively. The predominant land cover was other land (34.49%) and cultivated land (26.80%) in 1990, which transitioned to forest land (53.57%) and built-up land (23.07%) in 2019. Reforestation, cultivated land reduction, and built-up land expansion were the major land cover change processes on Haitan Island. The spatial pattern of forest, cultivated land, and built-up land change is mainly explained by the implementation of a ‘Grain for Green Project’ and ‘Comprehensive Pilot Zone’ policy on Haitan Island. Policy and human activities are the major drivers for land use change, including reforestation, population growth, and economic development. This study is unique because it demonstrates the use of GEE for continuous monitoring of the impact of reforestation efforts and urbanization in an island environment.

Description: Sustainable management of soil carbon (C) at the state level requires valuation of soil C regulating ecosystem services (ES) and disservices (ED). The objective of this study was to assess the value of regulating ES from soil organic carbon (SOC), soil inorganic carbon (SIC), and total soil carbon (TSC) stocks, based on the concept of the avoided social cost of carbon dioxide (CO2) emissions for the state of South Carolina (SC) in the United States of America (U.S.A.) by soil order, soil depth (0–200 cm), region and county using information from the State Soil Geographic (STATSGO) database. The total estimated monetary mid-point value for TSC in the state of South Carolina was $124.36B (i.e., $124.36 billion U.S. dollars, where B = billion = 109), $107.14B for SOC, and $17.22B for SIC. Soil orders with the highest midpoint value for SOC were: Ultisols ($64.35B), Histosols ($11.22B), and Inceptisols ($10.31B). Soil orders with the highest midpoint value for SIC were: Inceptisols ($5.91B), Entisols ($5.53B), and Alfisols ($5.0B). Soil orders with the highest midpoint value for TSC were: Ultisols ($64.35B), Inceptisols ($16.22B), and Entisols ($14.65B). The regions with the highest midpoint SOC values were: Pee Dee ($34.24B), Low Country ($32.17B), and Midlands ($29.24B). The regions with the highest midpoint SIC values were: Low Country ($5.69B), Midlands ($5.55B), and Pee Dee ($4.67B). The regions with the highest midpoint TSC values were: Low Country ($37.86B), Pee Dee ($36.91B), and Midlands ($34.79B). The counties with the highest midpoint SOC values were Colleton ($5.44B), Horry ($5.37B), and Berkeley ($4.12B). The counties with the highest midpoint SIC values were Charleston ($1.46B), Georgetown ($852.81M, where M = million = 106), and Horry ($843.18M). The counties with the highest midpoint TSC values were Horry ($6.22B), Colleton ($6.02B), and Georgetown ($4.87B). Administrative areas (e.g., counties, regions) combined with pedodiversity concepts can provide useful information to design cost-efficient policies to manage soil carbon regulating ES at the state level.