ALBERT

Description: B lymphocyte surface immunoglobulins (Smlg) were studied in 24 patients with multiple myeloma by means of anti-isotypic antisera, and their heavy and light chain isotypes were compared in each patient with those of the paraprotein. In 21 patients, lymphocyte Smlg consisted of only one light chain type, and in 16 of only 1 heavy chain type. However, the Smlg and paraprotein heavy and light chain types were identical in only 5 patients while in 6 they differed in heavy and light chain types, in 7 in light chain type, and in 4 in heavy chain type. In 2 patients with light chain myeloma, Smlg light chains were isotypically the same as the paraprotein. Isotypic discordance between paraprotein and Smlg may signify the proliferation of a second malignant clone with failure to differentiate into secreting plasma cells. Alternatively, it is conceivable that the lymphocyte Smlg could have the same idiotypic specificity as the paraprotein despite the isotypic differences, but this will require further studies using anti-idiotypic antisera.

Description: B lymphocyte surface immunoglobulins (Smlg) were studied in 24 patients with multiple myeloma by means of anti-isotypic antisera, and their heavy and light chain isotypes were compared in each patient with those of the paraprotein. In 21 patients, lymphocyte Smlg consisted of only one light chain type, and in 16 of only 1 heavy chain type. However, the Smlg and paraprotein heavy and light chain types were identical in only 5 patients while in 6 they differed in heavy and light chain types, in 7 in light chain type, and in 4 in heavy chain type. In 2 patients with light chain myeloma, Smlg light chains were isotypically the same as the paraprotein. Isotypic discordance between paraprotein and Smlg may signify the proliferation of a second malignant clone with failure to differentiate into secreting plasma cells. Alternatively, it is conceivable that the lymphocyte Smlg could have the same idiotypic specificity as the paraprotein despite the isotypic differences, but this will require further studies using anti-idiotypic antisera.

Description: From 1966 to 1979, the University of Missouri, the University of Arizona, and the Illinois State Museum conducted extensive interdisciplinary investigations of Late Pleistocene peat deposits associated with springs, some extinct, in the Pomme de Terre River Valley of the Ozark Highland, Missouri (fig 1). Most of the sites are now beneath the waters of the Harry S Truman reservoir. Archaeologic investigations in the area produced a remarkably long sequence of cultural change and development during the Holocene but produced no evidence of human presence in the area prior to 11,000 years ago despite diligent excavation of favorable bone-bearing deposits.

Description: The Geology of South Bedfordshire is now being exhibited more fully than hitherto, as the extension of the Midland Railway from Bedford to London is opening up a series of sections in the newer Seconday rocks which characterise this part of the county. The following notes were chiefly taken during a walk made last summer along the line, between the towns of Bedford and St. Alban's (Herts). For the first few miles the excavations are slight, and exhibit only the Drift sands and gravels of the rich valley of the Ouse, though these are well worthy of careful examination for flint implements and mammalian remains, which have been discovered on the north side of the river, at Biddenham, by J. Wyatt, Esq. About three miles from Bedford is an excavation in the Oxford clay; the upper portion is dark brown merging into dark blue beneath, and it abounds in fossil wood in various stages of carbonization, the colour of which ranges from brown to jet black; it is so abundant in places that some of the excavators fancied they were coming upon a coal-mine.

Description: Since my former communication on this subject, which appeared in the Geological Magazine for April last, (p. 154) I have had several opportunities of re-visiting some of the cuttings, on the Midland Railway, therein referred to, respecting which some doubts were expressed in reference to the age of the deposits exposed to view, and, as they are now completed, more precise observations can be made than when they were only just commenced. The cutting, south-east from Westoning, (which, in an Editorial note, was suggested might be of Tertiary age) exposes a dark heavy clay, which, upon the most rigid examination, furnished not the least trace of rolled fragments of Chalk or flints, or any other substance so frequent in the Tertiary clays of this neighbourhood, which would lead to the inference that it had been deposited subsequently to the Cretaceous era. It, however, contains what would strongly indicate that it is coæval with the Greensand, namely, a continuous band of coprolitic nodules, averaging about a foot in thickness. This layer passes through about one-third of the cutting, and may be traced from its commencement on the north-west side of the hill, passing along the face of the cutting with a gentle dip, until it reaches the level of the line, when it passes out of sight, nor does it re-appear on the south-east side of the excavation. The fossils associated with the nodules are Lamna, Belemnites, Parasmilia, and Terebratulœ, all of which are abundant in the coprolite beds at Hexton and other places in the immediate vicinity. Both above and below the coprolites the caly is identical in character, and must have been deposited eontemporaneously with its associated nodules, and, as far as I can judge, it is the equivalent of the bed h of the section given by Mr. W. Whitaker, in the Quart. Journ. Geol. Soc., vol. xxi., 1865, pp. 399, “On the Chalk of Bucks.” About the middle of the cutting is a considerable accumulation of light-brown coloured drift-sands, that lie in a basin-like hollow, that has been eroded from the summit of the hill.