Publication Date:
2011-11-18
Description:
Abstract 4099 Long term survivors of allogeneic SCT have increased risk factors for cardiovascular disease. The reason for this is unclear but chronic GVHD (cGVHD) has been implicated as a potential cause. We prospectively evaluated the impact of cGVHD on cardiovascular risk profiles in 109 allogeneic stem cell transplantation survivors. Transplants were performed at a single center between 1993 and 2006. Sixty-four survivors were informative at 5 years, 45 at 〉 10 years and 35 at both 5 and 10 years post-transplant. Median ages at transplant, 5 and 10 year follow-up were 34, 40 and 46 years, respectively. There were 62 male and 47 female survivors. Diagnoses at transplant included CML (56), acute leukemia (29), MDS (13), and others (9). Ninety-nine patients received 12–13Gy TBI-based conditioning followed by a 4-log T cell depleted SCT (15 marrow and 84 peripheral blood). Ten patients received non-myeloablative conditioning followed by unmanipulated peripheral blood stem cells. There were clinically relevant increases in prevalence of hypertension (p=
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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