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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 8 (1964), S. 73-87 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Critical specimen geometry parameters are varied to determine their effect on tensile behavior as a function of rate of testing. Their influence on elongation and energy absorption is pronounced, particularly at low values of specimen cross sectional area and thickness. These effects are attributed to surface imperfections resulting from specimen preparation, and to changes occurring in the combined stress pattern in the specimen. High speed photography and microscope analysis techniques have been developed to determine strain, strain distribution, and strain rate in the specimen gage section during deformation. Elongation measured outside the gage section can be a significant portion of overall specimen deformation; actual strain rate is a fraction of that obtained by assuming all deformation takes place in the gage section. Experimentation is statistically designed and the data statistically analyzed by sequential factorial analysis. Tensile stress response surfaces are accurately predicted by this technique.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2013-08-09
    Description: LINE-1 retrotransposons are abundant repetitive elements of viral origin, which in normal cells are kept quiescent through epigenetic mechanisms. Activation of LINE-1 occurs frequently in cancer and can enable LINE-1 mobilization but also has retrotransposition-independent consequences. We previously reported that in cancer, aberrantly active LINE-1 promoters can drive transcription of flanking unique sequences giving rise to LINE-1 chimeric transcripts (LCTs). Here, we show that one such LCT, LCT13, is a large transcript (〉300 kb) running antisense to the metastasis-suppressor gene TFPI-2 . We have modelled antisense RNA expression at TFPI-2 in transgenic mouse embryonic stem (ES) cells and demonstrate that antisense RNA induces silencing and deposition of repressive histone modifications implying a causal link. Consistent with this, LCT13 expression in breast and colon cancer cell lines is associated with silencing and repressive chromatin at TFPI-2 . Furthermore, we detected LCT13 transcripts in 56% of colorectal tumours exhibiting reduced TFPI-2 expression. Our findings implicate activation of LINE-1 elements in subsequent epigenetic remodelling of surrounding genes, thus hinting a novel retrotransposition-independent role for LINE-1 elements in malignancy.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 3
    Publication Date: 2013-07-27
    Description: Author(s): Arseni Goussev, Ross G. Lund, J. M. Robbins, Valeriy Slastikov, and Charles Sonnenberg Under a magnetic field along its axis, domain-wall motion in a uniaxial nanowire is much slower than in the fully anisotropic case, typically by several orders of magnitude (the square of the dimensionless Gilbert damping parameter). However, with the addition of a magnetic field transverse to the w... [Phys. Rev. B 88, 024425] Published Fri Jul 26, 2013
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 4
    Publication Date: 2000-06-01
    Print ISSN: 0006-3444
    Electronic ISSN: 1464-3510
    Topics: Biology , Mathematics , Medicine
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