ISSN:
1040-7685
Schlagwort(e):
enantioselective gas chromatography
;
immobilized permethyl-β-cyclodextrin
;
Chirasil-Dex
;
permethylated β-cyclodextrin dissolved in OV-1701
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Polysiloxane-anchored permethylated β-cyclodextrin (Chirasil-Dex) was used for enantiomeric separation by GC. Four types of Chirasil-Dex, containing up to 36% permethylated β-cyclodextrin by weight, were synthesized and compared with 10% permethylated β-cyclodextrin dissolved in OV-1701. The influence of the cyclodextrin weight percentage on the chiral separation factor α and on polarity, as expressed by the Kovats indices, was studied. The chiral separation factors α did not increase significantly above a threshold of ˜30% permethylated β-cyclodextrin by weight. The plots of α vs. weight percentage depend on the complexation strength of the chiral solutes, as do the Kovats indices; for weakly complexing solutes, changes in the cyclodextrin concentration result in larger changes in α, but in less pronounced changes in the Kovats indices, as compared to strongly complexing solutes. Column performances were investigated for immobilized and nonimmobilized stationary phases. As expected, immobilization properties were found to depend on the content of Si-H groups in the polysiloxane backbone. Immobilized columns exhibited a much better long-term stability of all chromatographic variables investigated.
Zusätzliches Material:
9 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/mcs.1220050103
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