ISSN:
1573-8221
Keywords:
opiate receptors
;
opioid peptides
;
adaptation
;
arrhythmia
;
stress
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract A decrease in the severity and occurrence of epinephrine- and CaCl2-induced cardiac arrhythmias and an increase in the β-endorphin and enkephalin contents in the brain, myocardium, adrenals, and blood plasma are observed in rats adapted to stress. The antiarrhythmic effect of adaptation is abolished by naloxone. A single administration of D-kyotorphin, a liberator of endogenous peptides, to intact animals also increases the resistance to arrhythmogenic factors. Intravenous administration of the enkephalinase inhibitor RB101 produces a significant antiarrhythmic effect in control animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446573
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