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  • 1
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    Symmetric quiver Hecke algebras and R-matrices of quantum affine algebras III (2015)
    Oxford University Press
    Details
    Publication Date: 2015-08-05
    Description: Let ${{\mathscr {C}}}^0_{{{\mathfrak {g}}}}$ be the category of finite-dimensional integrable modules over the quantum affine algebra $U_{q}'({{\mathfrak {g}}})$ and let $R^{A_\infty }{\mbox {-}\mathrm {gmod}}$ denote the category of finite-dimensional graded modules over the quiver Hecke algebra of type $A_{\infty }$ . In this paper, we investigate the relationship between the categories ${{\mathscr {C}}}^0_{A_{N-1}^{(1)}}$ and ${{\mathscr {C}}}^0_{A_{N-1}^{(2)}}$ by constructing the generalized quantum affine Schur–Weyl duality functors ${\mathcal {F}}^{(t)}$ from $R^{A_\infty }{\mbox {-}\mathrm {gmod}}$ to ${{\mathscr {C}}}^0_{A_{N-1}^{(t)}}\ (t=1,2)$ .
    Print ISSN: 0024-6115
    Electronic ISSN: 1460-244X
    Topics: Mathematics
    Published by Oxford University Press
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  • 2
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    On the origin of the soft photons of the high-synchrotron-peaked blazar PKS 1424+240 (2016)
    Oxford University Press
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    Publication Date: 2016-07-09
    Description: PKS 1424+240 is a distant very-high-energy gamma-ray BL Lac object with redshift z  = 0.601. It has been found that models utilizing pure synchrotron self-Compton (SSC) processes normally need extreme input parameters (e.g. a very low magnetic field intensity and an extraordinarily high Doppler factor) to explain this particular object spectral energy distributions (SEDs). In order to avoid these extreme model parameters, various other models have been proposed (e.g. the two-zone SSC model or lepto-hadronic model). In this work, we employ the traditional one-zone leptonic model after including a weak external Compton component in order to explore the simultaneous multiwavelength SEDs of PKS 1424+240 in both the high (2009) and the low (2013) state. We find that the input parameters of the magnetic field and Doppler factor are roughly consistent with those of other BL Lacs if a weak external photon field from either the broad line region (BLR) or the dust torus is assumed. However, the required energy density of seed photons from the BLR or torus is about three orders of magnitude lower than that the energy density estimated from the observations in luminous quasars (e.g. flat-spectrum radio quasars, FSRQs). This result suggests that the BLR/torus in BL Lacs is much weaker than that of luminous FSRQs (but has not fully disappeared), and that the inverse-Compton process of external photons from the BLR/torus may still play a role even in high-synchrotron-peaked blazars.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 3
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    Geometric realization of Khovanov-Lauda-Rouquier algebras associated with Borcherds-Cartan data (2013)
    Oxford University Press
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    Publication Date: 2013-09-26
    Description: We construct a geometric realization of the Khovanov–Lauda–Rouquier algebra R associated with a symmetric Borcherds–Cartan matrix A = ( a ij ) i , j I via quiver varieties. As an application, if a ii != 0 for any i I , we prove that there exists a one-to-one correspondence between Kashiwara's lower global basis (or Lusztig's canonical basis) of U A – (g) (respectively, V A ( )) and the set of isomorphism classes of indecomposable projective graded modules over R (respectively, R ).
    Print ISSN: 0024-6115
    Electronic ISSN: 1460-244X
    Topics: Mathematics
    Published by Oxford University Press
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  • 4
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    Inversions of time-domain spectral induced polarization data using Stretched Exponential (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉Summary〈/div〉We provide a two-stage approach to extract spectral induced polarization (SIP) information from time-domain IP data. In the first stage we invert DC data to recover the background conductivity. In the second, we solve a linear inverse problem and invert all time channels simultaneously to recover the IP parameters. The IP decay curves are represented by a Stretched Exponential (SE) rather than the traditional Cole-Cole model, and we find that defining the parameters in terms of their logarithmic values is advantageous. To demonstrate the capability of our simultaneous SIP inversion we use synthetic data simulating a porphyry mineral deposit. The challenge is to image a mineral body that is hosted within an alteration halo having the same chargeability but a different time constant. For a 2D problem, we were able to distinguish the body using our simultaneous inversion but we were not successful in using a sequential (or conventional) SIP inversion approach. For the 3D problem we recovered 3D distributions of the SIP parameters and used those to construct a 3D rock model having four rock units. Three chargeable units were distinguished. The compact mineralization zone, having a large time constant, was distinguished from the circular alteration halo that had a small time constant. Finally, to promote the use of the SIP technique, and to have further development of SIP inversion, all examples presented in this paper are available in our open source resources (〈a href="https://github.com/simpeg-research/kang-2018-spectral-inducedpolarization"〉https://github.com/simpeg-research/kang-2018-spectral-inducedpolarization〈/a〉).〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 5
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    Inversions of time-domain spectral induced polarization data using stretched exponential (2019)
    Oxford University Press
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉SUMMARY〈/div〉We provide a two-stage approach to extract spectral induced polarization (SIP) information from time-domain IP data. In the first stage we invert dc data to recover the background conductivity. In the second, we solve a linear inverse problem and invert all time channels simultaneously to recover the IP parameters. The IP decay curves are represented by a stretched exponential (SE) rather than the traditional Cole–Cole model, and we find that defining the parameters in terms of their logarithmic values is advantageous. To demonstrate the capability of our simultaneous SIP inversion we use synthetic data simulating a porphyry mineral deposit. The challenge is to image a mineral body that is hosted within an alteration halo having the same chargeability but a different time constant. For a 2-D problem, we were able to distinguish the body using our simultaneous inversion but we were not successful in using a sequential (or conventional) SIP inversion approach. For the 3-D problem we recovered 3-D distributions of the SIP parameters and used those to construct a 3-D rock model having four rock units. Three chargeable units were distinguished. The compact mineralization zone, having a large time constant, was distinguished from the circular alteration halo that had a small time constant. Finally, to promote the use of the SIP technique, and to have further development of SIP inversion, all examples presented in this paper are available in our open source resources (〈a href="https://github.com/simpeg-research/kang-2018-spectral-inducedpolarization"〉https://github.com/simpeg-research/kang-2018-spectral-inducedpolarization〈/a〉).〈/span〉
    Print ISSN: 2051-1965
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 6
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    Diversity and succession of autotrophic microbial community in high-elevation soils along deglaciation chronosequence (2016)
    Oxford University Press
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    Publication Date: 2016-08-26
    Description: Global warming has resulted in substantial glacier retreats in high-elevation areas, exposing deglaciated soils to harsh environmental conditions. Autotrophic microbes are pioneering colonizers in the deglaciated soils and provide nutrients to the extreme ecosystem devoid of vegetation. However, autotrophic communities remain less studied in deglaciated soils. We explored the diversity and succession of the cbbL gene encoding the large subunit of form I RubisCO, a key CO 2 -fixing enzyme, using molecular methods in deglaciated soils along a 10-year deglaciation chronosequence on the Tibetan Plateau. Our results demonstrated that the abundance of all types of form I cbbL (IA/B, IC and ID) rapidly increased in young soils (0–2.5 years old) and kept stable in old soils. Soil total organic carbon (TOC) and total nitrogen (TN) gradually increased along the chronosequence and both demonstrated positive correlations with the abundance of bacteria and autotrophs, indicating that soil TOC and TN originated from autotrophs. Form IA/B autotrophs, affiliated with cyanobacteria, exhibited a substantially higher abundance than IC and ID. Cyanobacterial diversity and evenness increased in young soils (〈6 years old) and then remained stable. Our findings suggest that cyabobacteria play an important role in accumulating TOC and TN in the deglaciated soils.
    Print ISSN: 0168-6496
    Electronic ISSN: 1574-6941
    Topics: Biology
    Published by Oxford University Press
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  • 7
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    Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model (2015)
    Oxford University Press
    Details
    Publication Date: 2015-10-10
    Description: Aberrant tau protein accumulation drives neurofibrillary tangle (NFT) formation in several neurodegenerative diseases. Currently, efforts to elucidate pathogenic mechanisms and assess the efficacy of therapeutic targets are limited by constraints of existing models of tauopathy. In order to generate a more versatile mouse model of tauopathy, somatic brain transgenesis was utilized to deliver adeno-associated virus serotype 1 (AAV1) encoding human mutant P301L-tau compared with GFP control. At 6 months of age, we observed widespread human tau expression with concomitant accumulation of hyperphosphorylated and abnormally folded proteinase K resistant tau. However, no overt neuronal loss was observed, though significant abnormalities were noted in the postsynaptic scaffolding protein PSD95. Neurofibrillary pathology was also detected with Gallyas silver stain and Thioflavin-S, and electron microscopy revealed the deposition of closely packed filaments. In addition to classic markers of tauopathy, significant neuroinflammation and extensive gliosis were detected in AAV1-Tau P301L mice. This model also recapitulates the behavioral phenotype characteristic of mouse models of tauopathy, including abnormalities in exploration, anxiety, and learning and memory. These findings indicate that biochemical and neuropathological hallmarks of tauopathies are accurately conserved and are independent of cell death in this novel AAV-based model of tauopathy, which offers exceptional versatility and speed in comparison with existing transgenic models. Therefore, we anticipate this approach will facilitate the identification and validation of genetic modifiers of disease, as well as accelerate preclinical assessment of potential therapeutic targets.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 8
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    CFGP 2.0: a versatile web-based platform for supporting comparative and evolutionary genomics of fungi and Oomycetes (2012)
    Oxford University Press
    Details
    Publication Date: 2012-12-20
    Description: In 2007, Comparative Fungal Genomics Platform (CFGP; http://cfgp.snu.ac.kr/ ) was publicly open with 65 genomes corresponding to 58 fungal and Oomycete species. The CFGP provided six bioinformatics tools, including a novel tool entitled BLASTMatrix that enables search homologous genes to queries in multiple species simultaneously. CFGP also introduced Favorite, a personalized virtual space for data storage and analysis with these six tools. Since 2007, CFGP has grown to archive 283 genomes corresponding to 152 fungal and Oomycete species as well as 201 genomes that correspond to seven bacteria, 39 plants and 105 animals. In addition, the number of tools in Favorite increased to 27. The Taxonomy Browser of CFGP 2.0 allows users to interactively navigate through a large number of genomes according to their taxonomic positions. The user interface of BLASTMatrix was also improved to facilitate subsequent analyses of retrieved data. A newly developed genome browser, Seoul National University Genome Browser (SNUGB), was integrated into CFGP 2.0 to support graphical presentation of diverse genomic contexts. Based on the standardized genome warehouse of CFGP 2.0, several systematic platforms designed to support studies on selected gene families have been developed. Most of them are connected through Favorite to allow of sharing data across the platforms.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 9
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    Bioenergy Supply and Environmental Impacts on Cropland: Insights from Multi-market Forecasts in a Great Lakes Subregional Bioeconomic Model (2015)
    Oxford University Press
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    Publication Date: 2015-11-06
    Description: Using subregional models of crop production choices in central Wisconsin and southwest Michigan, we predict biomass production, land use, and environmental impacts with details that are unavailable from national scale models. When biomass prices are raised exogenously, we find that the subregional models overestimate the supply, the land use, and the beneficial environmental aspects of perennial biomass crops. Multi-market price feedbacks tied to realistic policy parameters predict high threshold absolute prices for biomass to enter production, resulting in intensified production of biomass from annual grain crops with damaging environmental impacts. Multi-market feedbacks also predict regional specialization in energy biomass production in areas with lower yields of food crops. Policies promoting biofuels will not necessarily generate environmental benefits in the absence of environmental regulations.
    Keywords: Q16 - R&D ; Agricultural Technology ; Agricultural Extension Services, Q42 - Alternative Energy Sources, Q50 - General
    Print ISSN: 2040-5790
    Electronic ISSN: 2040-5804
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Economics
    Published by Oxford University Press
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  • 10
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    Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific ARHGEF4 and GPR148 (2012)
    Oxford University Press
    Details
    Publication Date: 2012-07-10
    Description: We have identified a rare small (~450 kb unique sequence) recurrent deletion in a previously linked attention-deficit hyperactivity disorder (ADHD) locus at 2q21.1 in five unrelated families with developmental delay (DD)/intellectual disability (ID), ADHD, epilepsy and other neurobehavioral abnormalities from 17 035 samples referred for clinical chromosomal microarray analysis. Additionally, a DECIPHER ( http://decipher.sanger.ac.uk ) patient 2311 was found to have the same deletion and presented with aggressive behavior. The deletion was not found in either six control groups consisting of 13 999 healthy individuals or in the DGV database. We have also identified reciprocal duplications in five unrelated families with autism, developmental delay (DD), seizures and ADHD. This genomic region is flanked by large, complex low-copy repeats (LCRs) with directly oriented subunits of ~109 kb in size that have 97.7% DNA sequence identity. We sequenced the deletion breakpoints within the directly oriented paralogous subunits of the flanking LCR clusters, demonstrating non-allelic homologous recombination as a mechanism of formation. The rearranged segment harbors five genes: GPR148, FAM123C, ARHGEF4 , FAM168B and PLEKHB2 . Expression of ARHGEF4 (Rho guanine nucleotide exchange factor 4) is restricted to the brain and may regulate the actin cytoskeletal network, cell morphology and migration, and neuronal function. GPR148 encodes a G-protein-coupled receptor protein expressed in the brain and testes. We suggest that small rare recurrent deletion of 2q21.1 is pathogenic for DD/ID, ADHD, epilepsy and other neurobehavioral abnormalities and, because of its small size, low frequency and more severe phenotype might have been missed in other previous genome-wide screening studies using single-nucleotide polymorphism analyses.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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