ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Electronic Resource

Patterns of circulating hepatitis B surface antigen variants among vaccinated children born to hepatitis B surface antigen carrier and non-carrier mothers (1998)

Ho, Mei-Shang ; Mau, Yi-Chien ; Lu, Chih-Feng ; [et al.]

Springer

Journal of biomedical science 5 (1998), S. 355-362

add to mindlist on the mindlist

Details

ISSN: 1423-0127

Keywords: Hepatitis B virus ; Hepatitis B surface antigen ; Quasispecies ; Vaccine ; Immune escape mutants ; Transmission

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Hepatitis B virus (HBV) variants that possessed missense mutation within the neutralization epitope of the major S antigen as defined by amino acid residues (aa#) 124–147, termed the ‘a’ determinant variants, were identified through a population-based serosurvey of 2,305 children of the vaccinated birth cohorts born after 1986. Data on the 678 nucleotides encoding the S antigen of HBV were available for 75 HBV strains that were collected from 63 vaccinated children and 12 unvaccinated or incompletely vaccinated children, and 21 HBV strains from 25 unvaccinated adults. Among the diverse patterns of one to three amino acid substitutions within the ‘a’ determinant, 145-Arg occurred most frequently (5/14); other variants were: 126-Ala, 127-Thr, 126-Ser/131-Asn/133-Thr, 129-His, 129-Arg, 123-Asn/131-Ile, 133-Leu, 141-Glu, and 141-Arg/144-Ala. Only one of these variants occurred in the 16 hepatitis B surface antigen (HBsAg)-carrier children born to HBsAg-negative mothers, whereas 12 of these variants occurred in the 20 (50%) children born to HBsAg-positive mothers. In addition, early administration of HBV vaccine within the noenatal period increased the likelihood of the emergence of these variants to 64.7% (11/17). Five of the 21 (23.8%) unvaccinated HBsAg-carrier adults harbored the ‘a’ determinant variants possessing mutations within aa# 125–136, i.e. the putative first loop formed by the cysteine disulfide bonds. Vaccinated children were likely to harbor HBV variants possessing mutations involving altered charge of side chains and/or its hydrophobicity of amino acid residues within the putative second loop between aa#140 and 146. Our data suggest that emergence of these HBV S gene mutants in the phase of HBV vaccination program would be most common among populations in whom perinatal/vertical transmission of HBV is most common, i.e. southeast Asian and the Taiwanese.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02253445

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

2

Electronic Resource

Diffusion-enhanced bioreactions: A hypothetical mechanism for plant cell aggregation (1993)

Hsu, Jyh-Ping ; Hsu, Wen-Chang ; Tsao, Heng-Kwong

Springer

Bulletin of mathematical biology 55 (1993), S. 869-889

add to mindlist on the mindlist

Details

ISSN: 1522-9602

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Mathematics

Notes: Abstract We show that the existence of diffusional resistance due to the presence of a solid phase can have a positive effect on the metabolic reactions of plant cells. In this case the efficiency of metabolic reactions, defined as the ratio of rate of production of biomass of aggregated cells/rate of production of biomass of dispersed cells, can be greater than unity for a certain range of aggregate sizes for both solid spheres (common plant cell aggregates) and hollow spheres (e.g.Volvox aggregates). This means that, under appropriate conditions, plant cells tend to stay in the aggregated form to improve the efficiency of their metabolic reactions. The result of the present analysis provides an explanation as to why aggregates of plant cells are observed under typical culture conditions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02460690

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

3

Electronic Resource

Parameter significance estimation and financial prediction (1993)

Hsu, W. ; Hsu, L. S. ; Tenorio, M. F.

Springer

Neural computing & applications 1 (1993), S. 280-286

add to mindlist on the mindlist

Details

ISSN: 1433-3058

Keywords: Neural networks ; Financial forecast ; Parameter significance ; Currency exchange rate

Source: Springer Online Journal Archives 1860-2000

Topics: Computer Science , Mathematics

Notes: Abstract This paper deals with the problem of parameter significance estimation, and its application to currency exchange rate prediction. The basic problem is that over the years, practitioners in the field of financial engineering have developed dozens of technical and fundamental indicators on the basis of which they try to predict financial time series. The practitioners are now faced with the problem of finding out which combinations of those indicators are most significant or relevant, and how their significance changes over time. The authors propose a novel neural architecture calledSupNet for estimating the significance of various parameters. The methodology is based on the principle of penalizing those features that are the largest contributors to the error term. Two algorithms based on this principle are proposed. This approach is different from related methodologies, which are based on the principle of removing parameters with the least significance. The proposed methodology is demonstrated on the next day returns of the DM-US currency exchange rate, and promising results are obtained.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02098747

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

4

Electronic Resource

Hodgkin's disease and anaplastic large cell lymphoma revisited (1995)

Hsu, Su-Ming ; Waldron, James ; Xie, Su-Su ; [et al.]

Springer

Journal of biomedical science 2 (1995), S. 302-313

add to mindlist on the mindlist

Details

ISSN: 1423-0127

Keywords: Hodgkin's disease ; Cytokine ; CD30 ; Lymphoma

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract In cultures, and in tissues as well, Hodgkin's and Reed-Sternberg (H-RS) cells and anaplastic large cell lymphoma (ALCL) cells are known to express a variety of cytokines, including IL-1, -5, -6, -8, -9, TNF-α, GM-CSF, M-CSF, TGF-β, CD70, CD80, and CD86. Various numbers of H-RS/ALCL cells may express cytokine receptors (R), such as CD30, CD40, IL-2R (CD25/CD122), IL-6R (CD126), IL-7R (CD127), TNF-R (CD120), TGF-β-R (CD105/endoglin), M-CSF-R (CD115), and SCF-R (CD117/c-kit receptor). All of these cytokines and cytokine receptors are implicated in the growth regulation of H-RS/ALCL cells, the histopathologic alterations in tissues, and the clinical manifestations in patients with Hodgkin's disease (HD) or ALCL. Many of these cytokines or cytokine receptors also play an important role in the pathogenesis of other types of lymphomas. In this review, we describe the cytokine or cytokine-receptor expression that is diacritic for H-RS/ALCL cells. The identification of such unique cytokine-cytokine receptor interactions is likely to explain the biologic property that distinguishes HD/ALCL from other types of lymphomas. These interactions include those of CD30L-CD30, CD40L-CD40, CD70-CD27, CD80/CD86-CD28, SCF-CD117, IL-9-IL9R, and IL-7-IL-7R. The H-RS/ALCL cells express IL-9 and two cytokine receptors, CD30 and CD117, which are observed infrequently in NHLs. Although IL-7 expression is not restricted to H-RS/ALCL cells, the expression of IL-7 in conjunction with IL-9 and/or CD117 may be regarded as unique for HD/ALCL because of an unusual combination and a synergistic activity among these cytokines. The expression of CD70 and CD80/CD86 (as cytokines) may exert a unique effect in HD because of intimate contact between H-RS cells and CD27/CD28-positive T cells. The expression of these costimulators (CD70 and CD80/CD86) and other adhesion/constimulator molecules such as CD54 and CD58, along with the secretion of soluble cytokines such as Il-1, IL-6, IL-7, or TNFs by H-RS/ALCL cells, could result in the profound T-cell proliferation often seen in lymph nodes involved by HD and some ALCL. On the other hand, the expression of CD30L and CD40L by surrounding T cells may affect the proliferation of H-RS/ALCL cells. The cytokine-cytokine receptor interaction between H-RS cells and T cells via direct cell-cell contact is bidirectional, a situation not commonly seen in NHLs.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02255217

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

5

Electronic Resource

Hodgkin's disease and anaplastic large cell lymphoma revisited (1996)

Hsu, Su-Ming ; Waldron, James ; Xie, Su-Su ; [et al.]

Springer

Journal of biomedical science 3 (1996), S. 1-13

add to mindlist on the mindlist

Details

ISSN: 1423-0127

Keywords: Hodgkin's disease ; Cytokine ; Lymphoma

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The true identity of Hodgkin's mononuclear cells and Reed-Sternberg (H-RS) cells has been a subject of controversy for decades. Those who believe that Hodgkin's disease (HD) is a heterogeneous disease may consider it to constitute lymphomas of various origins. However, this theory seems incompatible with the finding of similar phenotypic, biologic, and immunologic properties among most HD. We believe that, in the majority of cases, HD, except for LP and some LD-type HD, is a homogeneous disease despite differences in the degree of fibrosis and/or cellular reaction. The heterogeneity in cellular reactions is a result of secretion of various cytokines by H-RS cells, which may or may not be influenced by the presence of EBV. H-RS cells, and anaplastic large cell lymphoma (ALCL) cells as well, can express a combination of cytokines and cytokine receptors that is not seen in other types of lymphomas. The unique cytokine/receptor profile (e.g. the expression of c-kit-R/CD117), along with various properties associated with H-RS/ALCL cells, leads to a hypothesis that H-RS/ALCL cells are related to similar lymphohematopoietic progenitor cells with different etiologies and somewhat limited differentiation capacity. A number of H-RS cells may differentiate with limited capacity along the B-cell pathway and may be infected by EBV, which further complicates the biologic and immunologic properties of these cells. The majority of H-RS cells may also, however, differentiate along the antigen-presenting dendritic cell pathway, as indicated by the abundant expression of restin, CD15, CD40, CD54, CD58, CD80, and CD86. The majority of ALCL cells clearly differentiate to T cells, but some may acquire B-cell or histiocyte phenotypes. The progenitor cell hypothesis may explain (1) the variable expression of CD117, CD43, and CD34 as well as the absence of CD27, CD45 and CD45RA in H-RS cells; (2) the inconsistent and irregular patterns of phenotype and genotype and the various, often very limited, degrees of differentiation among these two types of lymphoma cells; (3) the existence of secondary HD or ALCL associated with rare types of lymphomas or leukemias, or vice versa; (4) the absence of recombinase and of the B-specific transcription factors BSAP; and (5) the frequent expression of IL-7 and IL-9 in H-RS cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02253573

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

6

Electronic Resource

Inactivation of protein kinase C in rat liver during late hypoglycemic phase of sepsis (1998)

Hsu, Chin ; Jao, Hsiao-Ching ; Yang, Shaw-Lang ; [et al.]

Springer

Molecular and cellular biochemistry 181 (1998), S. 181-189

add to mindlist on the mindlist

Details

ISSN: 1573-4919

Keywords: protein kinase C ; calcium- and phospholipid-dependent protein kinase ; kinase mediated phosphorylation ; glucose dyshomeostasis ; hypoglycemia ; sepsis ; septic shock ; rat liver

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Abstract Changes in protein kinase C (PKC) (calcium- and phospholipid-dependent protein kinase) activity in rat liver during different metabolic phases of sepsis were studied. Sepsis was induced by cecal ligation and puncture (CLP). Experiments were divided into three groups: control, early sepsis, and late sepsis. Early and late sepsis refers to those animals sacrificed at 9 and 18 h, respectively, after CLP. Hepatic PKC was extracted and partially purified by ammonium sulfate fractionation and DEAE-cellulose chromatography. PKC activity was assayed based on the rate of incorporation of 32p from [γ-32P]ATP into histone. The results show that during early sepsis, both membrane-associated and cytosolic PKC activities remained relatively unaltered. During late sepsis, membrane-associated PKC was unaffected while cytosolic PKC activity was decreased by 19.5-34.4%. Kinetic analysis of the data on cytosolic PKC during late phase of sepsis reveals that the Vmax values for ATP, histone, Ca2+, phosphatidylserine, and diacylglycerol were decreased by 23.4, 22.1, 19.5, 25, and 34.4%, respectively, with no changes in their Km values. These data indicate that cytosolic PKC activity was inactivated in rat liver during late hypoglycemic phase of sepsis. Since PKC-mediated phosphorylation plays an important role in regulating hepatic glucose metabolism, an inactivation of cytosolic PKC may contribute to the development of hypoglycemia during late phase of sepsis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1006853106320

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

7

Electronic Resource

Effects of fixed-charge distribution and pH on the electrophoretic mobility of biological cells (1994)

Hsu, J. -P. ; Hsu, W. -C. ; Chang, Y. -I.

Springer

Colloid & polymer science 272 (1994), S. 251-260

add to mindlist on the mindlist

Details

ISSN: 1435-1536

Keywords: Electrophoretic mobility ; cells ; fixed charge ; Donnan potential

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Abstract The electrophoretic mobility of biological cells is investigated theoretically. In particular, the effects of the distribution of the charges in the surface layer and the pH of bulk liquid phase on the mobility of cells are examined. The former includes the fixed charges due to the dissociation of the functional groups and the charges due to the penetrated electrolyte ions. The present analysis extends previous results in that the fixed charges are distributed nonuniformly across the surface layer of a cell. It is found that the distribution of the fixed charges in the surface layer has a significant effect on its electrophoretic mobility. Thus, assuming that the fixed charges are homogeneously distributed in the surface layer of a cell may lead to a significant deviation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00655495

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

8

Electronic Resource

Magnetic and transport properties of PrBa2Cu4O8-δ prepared at 1 atm oxygen pressure (1996)

Ku, H. C. ; You, Y. B. ; Sheen, S. R. ; [et al.]

Springer

Journal of low temperature physics 105 (1996), S. 1463-1468

add to mindlist on the mindlist

Details

ISSN: 1573-7357

Keywords: 74.10,+v ; 74.25.Bt, Ha ; 74.72.−h ; 74.72.Jt

Source: Springer Online Journal Archives 1860-2000

Topics: Physics

Notes: Abstract Measurements of physical properties were performed on the PrBa2Cu4O8-δ sample prepared by the sol-gel method and sintered in I atm oxygen pressure. Instead of exhibiting superconductivity as for R Y or Gd in the RBa2Cu4O8-δ compound. This compound is unstable, insulating but metallic-like at low temperatures. No superconductivity was observed down to 2 K. Since PrBa2Cu4O8-δ can be re-written as Cu2Ba2PrCu2O8-δ which is a compound of two CuO2-layers and two CuO-chains, the possibility of anomalous Pr antiferromagnetic ordering around 18 K observed from preliminary magnetic data and the effect of oxygen stoichiotmetry parameter δ on the metal-insulator transition are explored.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00753906

Permalink