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  • cervical dysplasia  (2)
  • Springer  (2)
  • American Institute of Physics (AIP)
  • 1
    Electronic Resource
    Electronic Resource
    A phase I trial of topically applied trans-retinoic acid in cervical dysplasia-clinical efficacy (1986)
    Springer
    Investigational new drugs 4 (1986), S. 241-244 
    Details
    ISSN: 1573-0646
    Keywords: trans-retinoic acid ; cervical dysplasia ; chemoprevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Forty-two patients were entered into a phase I trial to evaluate the vitamin A derivative, trans-retinoic acid, in cervical intraepithelial neoplasia. Treatment consisted of four consecutive 24-h applications of retinoids via an inert collagen sponge in a cervical cap. Patients were followed for response at 3-month intervals using cytology, colposcopy, and selected biopsies. Thirty-six patients were evaluable (mild dysplasia, 13; moderate dysplasia, 17; severe dysplasia, 6) with follow-up from 5 to 18 months. Complete regression was seen in 2/14 (14%) patients treated with concentrations of 0.05% → 0.1167% and in 10/22 (45%) patients treated with concentrations of 0.1583% → 0.484% (p 〈 0.05). One patient with negative biopsies at 12 months has subsequently recurred at 18 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179590
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  • 2
    Electronic Resource
    Electronic Resource
    Cervical tissue uptake of all-trans-retinoic acid delivered via a collagen sponge-cervical cap delivery device in patients with cervical dysplasia (1986)
    Springer
    Investigational new drugs 4 (1986), S. 245-249 
    Details
    ISSN: 1573-0646
    Keywords: cervical dysplasia ; all-trans-retinoic acid ; tissue uptake of anticancer drug ; collagen sponge-cervical cap
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract The present study was undertaken to evaluate the systemic absorption and cervical tissue uptake of all-transretinoic acid (TRA), delivered via a collagen spongecervical cap delivery device in patients with intraepithelial cervical dysplasia. Ten patients with histologically proven mild or moderate cervical dysplasia were included in this pharmacologic study. The two TRA concentrations (0.05% and 0.372%) selected for study represent the starting and maximally tolerated doses used in phase I clinical trial. All-trans-retinoic-11-3H acid (3H-TRA, 500 μCi) was used to facilitate cervical tissue uptake studies. Cervical biopsies and post-treatment blood samples were obtained from each patient after TRA exposure. The uptake of TRA into cervical tissues four hours after drug administration was significantly increased at the maximally tolerated TRA dose. There was a rapid decrease in cervical tissue concentration of TRA at the 0.372% dose between 4 and 24 h after drug exposure, suggesting a relatively short elimination half-life of TRA in cervical tissues. HPLC analysis of post-treatment blood samples indicate that there was no systemic absorption of TRA after local cervical administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179591
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    Paper (German National Licenses)
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