ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Copernicus  (25)
  • American Society of Hematology  (4)
  • American Institute of Physics (AIP)  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Transmission near-field scanning microscope for infrared chemical imaging (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 86 (1999), S. 2795-2799 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report transmission infrared near-field scanning microscopy (IR-NSOM) imaging of chemically amplified photoresist polymers patterned by ultraviolet exposure. Chemical specificity was attained using infrared wavelengths tuned to the 3 μm OH stretch absorption band of the polymer, a band sensitive to the chemical changes characteristic of the lithographic photochemical process of this material. Contrast mechanisms are discussed together with the IR-NSOM specifics, such as the fabrication of an infrared near-field probe with high throughput, which lead to an attainable resolution of λ/10 and a transmission sensitivity of 1%. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.371127
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Fourier-transform microwave spectrum, structure, harmonic force field, and hyperfine constants of sulfur chloride fluoride, ClSF (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 10037-10047 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The rotational spectrum of sulfur choride fluoride, ClSF, has been observed for the first time in the frequency range 8–26 GHz by means of a pulsed molecular jet Fourier-transform microwave spectrometer. The unstable sample molecule has been prepared using a pulsed electrical discharge in jets containing a mixture of SF6 and SCl2 in Ne. Besides the parent species 35Cl32S19F, the isotopomers 37Cl32S19F and 35Cl34S19F could be observed in natural abundance. Rotational constants and quartic centrifugal distortion constants as well as nuclear quadrupole coupling constants due to 35Cl and 37Cl and spin–rotation constants due to 35Cl, 37Cl, and 19F are given. The data were used for the determination of r0, rΔP, rs structural parameters. Additionally, the new data were used for the refinement of the molecular harmonic force field. Results from those harmonic force field calculations were applied in the evaluation of the ground-state average structure, rz, and the estimation of the equilibrium structure, re. The rs structure is r(SF)=160.653(162) pm, r(SCl)=199.437(65) pm, and (angle)(ClSF)=100.732(81)°. The diagonal elements of the 35Cl/37Cl quadrupole coupling tensors have been obtained, and are interpreted in terms of the bonding at 35Cl/37Cl. Negative 19F spin–rotation constants suggest a close analogy of the electronic structures of ClSF and SF2. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.474061
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    facet.materialart.
    Unknown
    High-resolution late Holocene sedimentary cores record the long history of the city of Cádiz (south-western Spain) (2020)
    Copernicus
    Details
    Publication Date: 2020-05-27
    Description: Today, coastal cities worldwide are facing major changes resulting from climate change and anthropogenic forcing, which requires adaptation and mitigation strategies to be established. In this context, sedimentological archives in many Mediterranean cities record a multi-millennial history of environmental dynamics and human adaptation, revealing a long-lasting resilience. Founded by the Phoenicians around 3000 years ago, Cádiz (south-western Spain) is a key example of a coastal resilient city. This urban centre is considered to be one of the first cities of western Europe and has experienced major natural hazards during its long history, such as coastal erosion, storms, and also tsunamis (like the one in 1755 CE following the destructive Lisbon earthquake). In the framework of an international, joint archaeological and geoarchaeological project, three cores have been drilled in a marine palaeochannel that ran through the ancient city of Cádiz. These cores reveal a ≥50 m thick Holocene sedimentary sequence. Importantly, most of the deposits date from the 1st millennium BCE to the 1st millennium CE. This exceptional sedimentary archive will allow our scientific team to achieve its research goals, which are (1) to reconstruct the palaeogeographical evolution of this specific coastal area; (2) to trace the intensity of activities of the city of Cádiz based on archaeological data, as well as geochemical and palaeoecological indicators; and (3) to identify and date high-energy event deposits such as storms and tsunamis.
    Print ISSN: 1816-8957
    Electronic ISSN: 1816-3459
    Topics: Geosciences
    Published by Copernicus on behalf of International Continental Scientific Drilling Program.
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Revisiting Late Pleistocene glacier dynamics north-west of the Feldberg, southern Black Forest, Germany (2020)
    Copernicus
    Details
    Publication Date: 2020-06-26
    Description: The southern Black Forest was temporarily covered by a ∼1000 km2 large ice cap during the Late Pleistocene. However, during the last glaciation maximum in the Alps the atmospheric circulation over Europe was presumably characterised by the advection of humid air masses from the Mediterranean Sea. As a consequence, the ice cap of the Black Forest was likely in a leeward position due to its location north of the Alps. This raises the question of whether it reached its last maximum extent simultaneously with the glaciers in the Alps. As modern dating techniques have hitherto not been applied to the southern Black Forest, the timing of the last local glaciation maximum remains poorly constrained. As a first step towards an independent regional glacier chronology, we present a critical re-examination of glacial landforms in the area north-west of the highest summit of the Black Forest (Feldberg, 1493 m a.s.l.). It relies on both the analysis of remote sensing data and field mapping. The review of previous studies highlights important disagreements regarding the location of ice-marginal positions and their correlation. In addition, our findings challenge earlier studies on the glaciation of the Black Forest: some previously described ice-marginal positions could not be confirmed, whereas some of the newly identified moraines are described for the first time. This highlights the need for detailed geomorphological investigations prior to the application of geochronological methods. A multi-ridged series of terminal moraines in one of the studied valleys, Sankt Wilhelmer Tal, is proposed as the main target for future dating. Due to discrepancies with earlier studies, future efforts should reinvestigate other key areas related to the last glaciation of the southern Black Forest.
    Print ISSN: 0424-7116
    Electronic ISSN: 2199-9090
    Topics: Geosciences , History
    Published by Copernicus on behalf of Deutsche Quartärvereinigung.
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Podoplanin expression in primary brain tumors induces platelet aggregation and increases risk of venous thromboembolism (2017)
    American Society of Hematology
    Details
    Publication Date: 2017-03-30
    Description: Key Points Brain tumor patients have a very high risk of VTE. Podoplanin expression by primary brain tumors induces platelet aggregation and is associated with hypercoagulability and a high risk of VTE.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    High Soluble P-Selectin and Low Platelet Count as Thrombosis Risk Markers in Glioma Patients. (2009)
    American Society of Hematology
    Details
    Publication Date: 2009-11-20
    Description: Abstract 2985 Poster Board II-961 Background Glioma patients are at high risk for venous thromboembolism (VTE). However, predictive laboratory parameters have not been identified. High platelet count (PLC) and increased soluble P-selectin (sP-selectin) have been reported as risk factors in cancer patients, so we investigated sP-selectin and PLC as risk markers in glioma patients. Methods The Cancer and Thrombosis Study (CATS) is a prospective observational study, whose endpoint is the occurrence of objectively confirmed VTE. sP-selectin was measured in the third week after neurosurgical intervention using a human sP-selectin Immunoassay (R&D Systems®, Minneapolis, USA). Multivariable Cox regression analysis was applied to calculate hazard ratios (HR) for VTE, including PLC, sP-selectin, age, sex and type of surgery. Results 140 patients with newly diagnosed high grade glioma were analysed (52 women; median age 54.5 years [interquartile range (IQR): 42.8-5.1]) during a median observation time of 309 (range: 3-1664) days. Twenty patients developed VTE (6 women, 14 men), of which 2 events were fatal pulmonary embolisms. The cumulative probability of VTE was 10% at six and 15% at twelve months. sP-selectin levels (ng/mL) were higher in patients with VTE compared to those without (median=51.8, IQR: 36.9–66.0 versus median=38.8, IQR: 30.7–52.1, p=0.011). Interestingly, PLC (G/l) was significantly lower in patients with (median=214, IQR: 166-248) than in those without VTE (median=255, IQR: 200-327; p=0.011). In multivariable regression analysis high sP-selectin (75th percentile: 55.1ng/mL) and low PLC (25th percentile: 198G/L) were significant risk markers of VTE (HR=3.4, 95% CI 1.3-9.0, and HR=3.3, 95% CI 1.2-8.8, respectively). Conclusion Our study revealed two strong predictive markers for VTE in glioma patients. Elevated sP-selectin is associated with a three-fold increased risk of thrombosis. In contrast to patients with other solid tumours, in glioma patients low PLC is associated with increased thrombosis risk. Disclosures: Pabinger: Amgen Inc.: Honoraria, Membership on an entity's Board of Directors or advisory committees.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis (2012)
    American Society of Hematology
    Details
    Publication Date: 2012-09-20
    Description: Langerhans cell histiocytosis (LCH) is a clinically and histologically heterogeneous disorder. Its classification as either reactive inflammatory or neoplastic has been a matter of debate. However, the recent finding of frequent BRAFV600E mutations in LCH argues for the latter. The exact cell type that harbors the mutation and is responsible for proliferation remains to be identified. We here apply a BRAFV600E mutation-specific antibody to detect the BRAF mutant cells in lesions from 89 patients with LCH. We found BRAFV600E mutations in 34 of 89 (38%) lesions. In lesions with the BRAFV600E mutation, the majority of cells coexpressing S-100 and CD1a harbored mutant BRAFV600E protein. These cells also expressed CD14 and CD36, whereas various fractions exhibited CD207. On the other hand, CD80 and CD86 expression was also present on BRAFV600E-positive cells. Thus, cells of variable maturation, exhibiting an immunohistochemical profile compatible either with myeloid cell or with dedifferentiated Langerhans cell antigens, carry the BRAFV600E mutation. In conclusion, we identify and characterize the neoplastic cells in LCH with BRAFV600E mutations by applying a mutation-specific marker and demonstrate feasibility for routine screening.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Sources and pathways of biocides and their transformation products in urban storm water infrastructure of a 2 ha urban district (2021)
    Copernicus
    Details
    Publication Date: 2021-08-20
    Description: Biocides used in film protection products leaching from facades are known to be a potential threat to the environment. This study identifies individual sources and entry pathways in a small-scale urban area. We investigate emissions of commonly used biocides (terbutryn, diuron, and octylisothiazolinone – OIT) and some of their transformation products (TPs; diuron-desmethyl, terbumeton, terbuthylazine-2-hydroxy, and terbutryn-desethyl) from a 2 ha residential area 13 years after construction has ended. Sampling utilizes existing urban water infrastructure representative for decentralized storm water management in central and northern Europe and applies a two-step approach to (a) determine the occurrence of biocides above water quality limits (i.e., predicted no-effect concentration, PNEC) and (b) identify source areas and characterize entry pathways into surface and groundwater. Monitoring focuses on the analysis of selected biocides and TPs by liquid chromatography–mass spectrometry/mass spectrometry (LC-MS/MS) in water samples taken from facades, rainwater pipes, drainage, and storm water infiltration systems. In standing water in a swale, we found high concentrations of diuron (174 ng L−1) and terbutryn (40 ng L−1) above PNEC for surface water. We confirmed expected sources, i.e., facades. Sampling of rain downpipes from flat roofs identified additional sources of all biocides and two TPs of terbutryn and one TP of diuron. Diuron and terbutryn were found in three drainage pipes representing different entry pathways of biocides. In one drainage pipe collecting road runoff, only diuron-desmethyl and terbutryn-desethyl were detected. In two other drainage pipes collecting infiltrated water through soil, terbuthylazine-2-hydroxy was additionally detected. One of the pipes collecting infiltrated water through soil concentration showed the highest concentrations of terbutryn and two of its TPs (terbutryn-desethyl and terbuthylazine-2-hydroxy). This suggests a high leaching potential of terbutryn. The applied two-step approach determined sources and pathways of biocide and their TPs. This study contributes to expanding knowledge on their entry and distribution and, thus, eventually towards reducing emissions.
    Print ISSN: 1027-5606
    Electronic ISSN: 1607-7938
    Topics: Geography , Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Incidence, risk factors and outcomes of venous and arterial thromboembolism in immune checkpoint inhibitor therapy (2020)
    American Society of Hematology
    Details
    Publication Date: 2020-10-16
    Description: The risk of venous and arterial thromboembolism (VTE/ATE) associated with immune checkpoint inhibitors is currently unclear, and clinical trials evaluating these agents in patients with cancer did not provide information. Our aim was to quantify risk of VTE/ATE in a cohort of patients treated with immune checkpoint inhibitors, explore clinical impact, and investigate potential clinical risk factors. Patients treated with an immune checkpoint inhibitor at the Medical University of Vienna from 2015-2018 were identified using the in-house pharmacy records (n=672; most frequent entities: 30.4% melanoma, 24.1% non-small-cell lung cancer; 86% stage-IV-disease). A retrospective chart-review was performed to screen for VTE and/or ATE. Cumulative incidences and between-group differences were analysed within a competing-risk framework. Multi-state modelling was applied to study the impact of VTE/ATE on mortality. Over a median follow-up of 8.5 months, 47 VTE and 9 ATE were observed. Cumulative incidences of VTE and ATE were 12.9% [95% confidence interval (CI): 8.2-18.5)] and 1.8% [95%CI: 0.7-3.6]. Occurrence of VTE was associated with increased mortality (transition hazard-ratio (THR): 3.09 [95%CI: 2.07-4.60]. History of VTE predicted VTE occurrence (subdistribution hazard ratio (SHR): 3.69 [2.00-6.81]) and distant metastasis was non-significantly associated with VTE risk (SHR: 1.71 [95%CI: 0.62-4.73]). No association of VTE with ECOG performance-status, Charlson-Comorbidity-Index or the Khorana-score was observed, and rates of VTE were comparable among subgroups of tumour types and checkpoint-inhibitory agents. In conclusion, patients with cancer under immune checkpoint inhibitor therapy are at high risk of thromboembolism, especially VTE. Furthermore, VTE occurrence was associated with increased risk of mortality.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Circumpolar polynya regions and ice production in the Arctic: results from MODIS thermal infrared imagery from 2002/2003 to 2014/2015 with a regional focus on the Laptev Sea (2016)
    Copernicus
    Details
    Publication Date: 2016-12-15
    Description: High-resolution MODIS thermal infrared satellite data are used to infer spatial and temporal characteristics of 17 prominent coastal polynya regions over the entire Arctic basin. Thin-ice thickness (TIT) distributions (≤ 20 cm) are calculated from MODIS ice-surface temperatures, combined with ECMWF ERA-Interim atmospheric reanalysis data in an energy balance model for 13 winter seasons (2002/2003 to 2014/2015; November to March). From all available MODIS swath data, daily thin-ice thickness composites are computed in order to derive quantities such as polynya area and total thermodynamic (i.e., potential) ice production. A gap-filling approach is applied to account for cloud and data gaps in the MODIS composites. All polynya regions combined cover an average thin-ice area of 226.6 ± 36.1 × 103 km2 in winter. This allows for an average total winter-accumulated ice production of about 1811 ± 293 km3, whereby the Kara Sea region, the North Water polynya (both 15 %), polynyas on the western side of Novaya Zemlya (20 %), as well as scattered smaller polynyas in the Canadian Arctic Archipelago (all combined 12 %) are the main contributors. Other well-known sites of polynya formation (Laptev Sea, Chukchi Sea) show smaller contributions and range between 2 and 5 %. We notice distinct differences to earlier studies on pan-Arctic polynya characteristics, originating in some part from the use of high-resolution MODIS data, as the capability to resolve small-scale (〉 2 km) polynyas and also large leads are increased. Despite the short record of 13 winter seasons, positive trends in ice production are detected for several regions of the eastern Arctic (most significantly in the Laptev Sea region with an increase of 6.8 km3 yr−1) and the North Water polynya, while other polynyas in the western Arctic show a more pronounced variability with varying trends. We emphasize the role of the Laptev Sea polynyas as being a major influence on Transpolar Drift characteristics through a distinct relation between increasing ice production and ice area export. Overall, our study presents a spatially highly accurate characterization of circumpolar polynya dynamics and ice production, which should be valuable for future modeling efforts of atmosphere–ice–ocean interactions in the Arctic.
    Print ISSN: 1994-0416
    Electronic ISSN: 1994-0424
    Topics: Geography , Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...