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  • Oxford University Press  (45)
  • American Institute of Physics (AIP)  (20)
  • International Union of Crystallography (IUCr)  (11)
  • American Physical Society (APS)  (9)
  • 11
    Publication Date: 2015-12-16
    Description: We present the first Doppler images of the active eclipsing binary system SZ Psc, based on the high-resolution spectral data sets obtained in 2004 November and 2006 September–December. The least-squares deconvolution technique was applied to derive high signal-to-noise profiles from the observed spectra of SZ Psc. Absorption features contributed by a third component of the system were detected in the LSD profiles at all observed phases. We estimated the mass and period of the third component to be about 0.9 M and 1283 ± 10 d, respectively. After removing the contribution of the third body from the least-squares deconvolved profiles, we derived the surface maps of SZ Psc. The resulting Doppler images indicate significant star-spot activities on the surface of the K subgiant component. The distributions of star-spots are more complex than that revealed by previous photometric studies. The cooler K component exhibited pronounced high-latitude spots as well as numerous low- and intermediate-latitude spot groups during the entire observing seasons, but did not show any large, stable polar cap, different from many other active RS CVn-type binaries.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 12
    Publication Date: 2016-06-01
    Description: : Identifying chemical probes or seeking scaffolds for a specific biological target is important for protein function studies. Therefore, we create the Annotated Scaffold Database (ASDB), a computer-readable and systematic target-annotated scaffold database, to serve such needs. The scaffolds in ASDB were derived from public databases including ChEMBL, DrugBank and TCMSP, with a scaffold-based classification approach. Each scaffold was assigned with an InChIKey as its unique identifier, energy-minimized 3D conformations, and other calculated properties. A scaffold is also associated with drugs, natural products, drug targets and medical indications. The database can be retrieved through text or structure query tools. ASDB collects 333 601 scaffolds, which are associated with 4368 targets. The scaffolds consist of 3032 scaffolds derived from drugs and 5163 scaffolds derived from natural products. For given scaffolds, scaffold-target networks can be generated from the database to demonstrate the relations of scaffolds and targets. Availability and implementation: ASDB is freely available at http://www.rcdd.org.cn/asdb/ with the major web browsers. Contact: junxu@biochemomes.com or xujun9@mail.sysu.edu.cn Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
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  • 13
    Publication Date: 2015-02-17
    Description: Long non-coding RNA HOX transcript antisenseRNA ( HOTAIR ) has been widely identified to participate in tumour pathogenesis, acting as a promoter in colorectal cancer carcinogenesis. However, the association between genetic variants in HOTAIR and cancer risk has not yet been reported. In the present study, we performed a two-stage case–control study to investigate the association between HOTAIR tagSNPs and the risk of colorectal cancer. We found that individuals with rs7958904 CC genotype had a significantly decreased risk of colorectal cancer in both Stage 1 and 2, compared with those carrying GG genotype [odds ratio (OR) = 0.70, 95% confidence interval (CI) = 0.51–0.97 in Stage 1; OR = 0.58, 95% CI = 0.37–0.91 in Stage 2; OR = 0.67, 95% CI = 0.51–0.87 in combined stage]. The subsequently stratified analyses showed that the protective effect of rs7958904 was more pronounced in several subgroups. In summary, our study showed that genetic variants in HOTAIR were associated with risk of colorectal cancer and rs7958904 may act as a potential biomarker for predicting the risk of colorectal cancer.
    Print ISSN: 0267-8357
    Electronic ISSN: 1464-3804
    Topics: Biology , Medicine
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  • 14
    Publication Date: 2011-05-21
    Description: Author(s): S. K. Chamoli, A. E. Stuchbery, S. Frauendorf, J. Sun, Y. Gu, R. F. Leslie, P. T. Moore, A. Wakhle, M. C. East, T. Kibédi, and A. N. Wilson The transient-field technique has been used in both conventional kinematics and inverse kinematics to measure the g  factors of the 2 1 + states in the stable even isotopes of Ru, Pd, and Cd. The statistical precision of the g (2 1 + ) values has been significantly improved, allowing a critical comparison ... [Phys. Rev. C 83, 054318] Published Fri May 20, 2011
    Keywords: Nuclear Structure
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
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  • 15
    Publication Date: 2011-06-03
    Description: Author(s): W. Fan, J. Cao, J. Seidel, Y. Gu, J. W. Yim, C. Barrett, K. M. Yu, J. Ji, R. Ramesh, L. Q. Chen, and J. Wu Superheating and supercooling effects are characteristic kinetic processes in first-order phase transitions, and asymmetry between them is widely observed. In materials where electronic and structural degrees of freedom are coupled, a wide, asymmetric hysteresis may occur in the transition between e... [Phys. Rev. B 83, 235102] Published Thu Jun 02, 2011
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 16
    Publication Date: 2014-12-03
    Description: Contactless electroreflectance is applied to study the band gap (E 0 ) and spin-orbit splitting (Δ SO ) in InP 1−x Bi x alloys with 0 
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 17
    Publication Date: 2014-12-17
    Description: Natural tetracyclic diterpenoid aphidicolin is a potent and specific inhibitor of B-family DNA polymerases, haltering replication and possessing a strong antimitotic activity in human cancer cell lines. Clinical trials revealed limitations of aphidicolin as an antitumor drug because of its low solubility and fast clearance from human plasma. The absence of structural information hampered the improvement of aphidicolin-like inhibitors: more than 50 modifications have been generated so far, but all have lost the inhibitory and antitumor properties. Here we report the crystal structure of the catalytic core of human DNA polymerase α (Pol α) in the ternary complex with an RNA-primed DNA template and aphidicolin. The inhibitor blocks binding of dCTP by docking at the Pol α active site and by rotating the template guanine. The structure provides a plausible mechanism for the selectivity of aphidicolin incorporation opposite template guanine and explains why previous modifications of aphidicolin failed to improve its affinity for Pol α. With new structural information, aphidicolin becomes an attractive lead compound for the design of novel derivatives with enhanced inhibitory properties for B-family DNA polymerases.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 18
    Publication Date: 2014-02-15
    Description: We present Doppler images of RS CVn-type binary II Peg based on two data sets obtained in 2004 February and November. In order to improve signal-to-noise ratio and reliability, we apply least-squares deconvolution technique to calculate average profiles from 2032 photospheric absorption lines. Both of the resulting surface images show a wide latitude distribution of starspots. Most spots are concentrated at a high-latitude belt above 60° and a low-latitude belt near equator. The starspots evolved dramatically between two observing runs, which may indicate shorter time-scale evolution in this epoch, especially for low-latitude belt. There is no stable preferred active longitude that can be found in our images. We also find out a possible phenomenon that the intermediate-latitude spot migrated poleward and merged with the high-latitude spot to make it stronger, which may reveal a more complex behaviour of starspots on II Peg. A potential change of orbital ephemeris zero-point was detected. This may imply an orbital period change of II Peg like other active close binaries.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 19
    Publication Date: 2014-12-20
    Description: We present Doppler images of both components of the eclipsing binary system ER Vul, based on the spectra obtained in 2004 November, 2006 September and 2008 November. The least-squares deconvolution technique is used for enhancing the signal-to-noise ratios of the observed profiles. The new surface images reveal that both stars of ER Vul show strong starspot activities and the starspots appear at various latitudes. The surface maps of 2006 and 2008 both show the presence of large high-latitude starspots on each component of ER Vul. We find no obvious phase shift of the active regions during our observations. The longitude distributions of starspots are non-uniform on both stars. At low-to-mid latitudes, the active regions are almost exclusively found in the hemisphere facing the other star. However, we find no pronounced concentration of spots at the sub-stellar points.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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  • 20
    Publication Date: 2014-12-29
    Description: We present Doppler images of both components of the eclipsing binary system ER Vul, based on the spectra obtained in 2004 November, 2006 September and 2008 November. The least-squares deconvolution technique is used for enhancing the signal-to-noise ratios of the observed profiles. The new surface images reveal that both stars of ER Vul show strong starspot activities and the starspots appear at various latitudes. The surface maps of 2006 and 2008 both show the presence of large high-latitude starspots on each component of ER Vul. We find no obvious phase shift of the active regions during our observations. The longitude distributions of starspots are non-uniform on both stars. At low-to-mid latitudes, the active regions are almost exclusively found in the hemisphere facing the other star. However, we find no pronounced concentration of spots at the sub-stellar points.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
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