Publication Date:
2016-02-26
Description:
Article Heart contraction, which is decreased in disease, is determined by Ca 2+ binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin C variants, suggesting a new therapy for diseased hearts. Nature Communications doi: 10.1038/ncomms10794 Authors: Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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