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  • Articles  (282)
  • Springer  (282)
  • American Geophysical Union (AGU)
  • Molecular Diversity Preservation International
  • Mathematics  (282)
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  • Articles  (282)
Journal
  • 1
    ISSN: 1433-3058
    Keywords: Neural networks ; Length-of-stay ; Psychiatry ; Resource utilization ; Back propagation ; Field study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract Demands for health care reform will increase service utilization, much of which will fall on a system of expanded primary care providers, many of whom will not be specialists in psychiatry. These providers will need tools to augment their decision-making process. In this paper, we explore the use of Artificial Neural Networks (ANNs) in three different field sites to predict inpatient psychiatric Length-Of-Stay (LOS). This study describes the development and implementation of a runtime system in three different psychiatric facilities. Data was collected at these respective sites using the runtime system, and then this data was used to retrain the networks to determine if site-specific data would improve accuracy of prediction of LOS. The results indicate that ANNs trained with state hospital data could accurately predict LOS in two different community hospital psychiatric units. When the respective ANNs were retrained with approximately 10% new data from these specific hospitals, rates of improvement ranged from 3% to 15%. Our findings demonstrate that an ANN can adapt to different treatment settings and, when retrained, significantly improve prediction of LOS. Prediction rates by the ANN after retraining are comparable to results of a clinical team.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 62 (2000), S. 1001-1001 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 62 (2000), S. 675-694 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Mean fitness is non-decreasing in the symmetry sector of the frequency trajectory followed in competitive replication at sublinear propagation rates (parabolic time course). This sector contains the pairwise symmetric distribution of species frequencies and its neighboring states, and represents at least half the possible states of an evolving sublinear system. States in the non-symmetry sector produce a negative rate of change in mean fitness. The heterogeneous steady state attained in a finite sublinear system is destabilized by formation of a variant with above-threshold fitness. Evolution in the post-steady-state interval elevates the fitness threshold for coexistence. Contrary to the proposition that ‘parabolic growth invariably results in the survival of all competing species’, only species with sufficient fitness to avoid subthreshold fitness survive.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 53 (1991), S. 751-768 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Two series expressions were obtained that give the first and second order rates of change in population fitness during competitive replication at elevated mutation rates. At their zeroerror limit, the respective power series reduces to the second (Fisher’s theorem) and third moments of the fitness distribution. The first series maximized the variation in mean polymer fitness, for a given amount of population covariance. From experimental results reported by Spiegelman’s group on evolutionin vitro among Qβ RNA variants, it was demonstrated: (i) terms in the (second) series fall-off at a rate broadly equal to the replicase error (ε≅10−4); (ii) the rate of change in mean RNA fitness (polymer formation rate constant) corresponds to the variance in fitness; and (iii) agreement exists between second order rate changes in fitness and the third moment (skewness) regression line, extending over 20 successive replication reactions. The impact of these findings on the standard model of evolution has been discussed.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 58 (1996), S. 99-101 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract As in Darwinian evolution, population fitness increases among replicating molecules whose propagation rate coefficients form a normal (symmetric) distribution, even when replication kinetics are fractional order.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of mathematical biology 58 (1996), S. 65-97 
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A theory has been proposed that encompasses pre-replication changes in RNA synthesis and non-gradual variant formation, in addition to competitive replication. Using a fundamental theorem of natural selection and maximum principle scaled to nucleotide condensation, evolutionin vitro was demonstrated to maximally damp both kinetic and thermodynamic forces driving this reaction, from its pre-replication stage. This led to the finding that evolution follows a path of least action. These principles form the framework for a general theory of evolution, whose scope extends beyond evolution modeled by synthesis of non-interacting RNA molecules. It applies, in particular, to standard processes, such as competitive crystallization. In calculations simulatingde novo formation of self-replicating RNA molecules in the Qβ replicase system, spontaneous changes in strand secondary structure promoted the transition from random copolymerization to template-directed polymerization. This finding indicates selection preceded genome self-propagation. Non-gradual species formation was attributed to the presence of heterogeneous thermodynamic forces. Growth unconstrained by competition follows mutation to a variant able to utilize a free energy source alien to its progenitors. Evolution in a heterogeneous system can, therefore, exhibit discontinuous rates of species formation and spawn new species populations. Natural selection among competing self-propagators thus gives way to a principle of wider scope stating that evolution optimally damps the physicochemical forces causing change within an evolving system.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Mathematical programming 18 (1980), S. 138-145 
    ISSN: 1436-4646
    Keywords: Set-covering Problem ; Branch and Bound ; Lower Bounds ; Steiner Triple Systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract Fulkerson et al. have given two examples of set covering problems that are empirically difficult to solve. They arise from Steiner triple systems and the larger problem, which has a constraint matrix of size 330 × 45 has only recently been solved. In this note, we show that the Steiner triple systems do indeed give rise to a series of problems that are probably hard to solve by implicit enumeration. The main result is that for ann variable problem, branch and bound algorithms using a linear programming relaxation, and/or elimination by dominance require the examination of a super-polynomial number of partial solutions
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Mathematical programming 6 (1974), S. 224-228 
    ISSN: 1436-4646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of theoretical probability 8 (1995), S. 693-701 
    ISSN: 1572-9230
    Keywords: Central limit theorem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We give an elementary proof of the local central limit theorem for independent, non-identically distributed, integer valued and vector valued random variables.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Annals of operations research 46-47 (1993), S. 409-430 
    ISSN: 1572-9338
    Keywords: Linear programming ; Phase I ; nonlinear programming ; least squares ; quadratic programming ; strict improvement ; degeneracy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Notes: Abstract Instead of trying to recognize and avoid degenerate steps in the simplex method (as some variants do), we have developed a new Phase I algorithm that is impervious to degeneracy. The new algorithm solves a non-negative least-squares problem in order to find a Phase I solution. In each iteration, a simple two-variable least-squares subproblem is used to select an incoming column to augment a set of independent columns (called “basic”) to get a strictly better fit to the right-hand side. Although this is analogous in many ways to the simplex method, it can be proved that strict improvement is attained at each iteration, even in the presence of degeneracy. Thus cycling cannot occur, and convergence is guaranteed. This algorithm is closely related to a number of existing algorithms proposed for non-negative least-squares and quadratic programs. When used on the 30 smallest NETLIB linear programming test problems, the computational results for the new Phase I algorithm were almost 3.5 times faster than a particular implementation of the simplex method; on some problems, it was over 10 times faster. Best results were generally seen on the more degenerate problems.
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