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  • Copepoda  (2)
  • flowing polymer solution  (2)
  • 6-mercaptopurine  (1)
  • Springer  (5)
  • American Geophysical Union (AGU)
  • American Meteorological Society (AMS)
  • Blackwell Publishing Ltd
Collection
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 6-thiouric acid and 6-mercaptopurine in renal allograft recipients after oral administration of azathioprine (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 265-271 
    Details
    ISSN: 1432-1041
    Keywords: azathioprine ; 6-thiouric acid ; 6-mercaptopurine ; renal transplantation ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (6-TU) and 6-mercaptopurine (6-MP), metabolites of AZA, may provide more readily measurable indices of the pharmacologic activity of AZA. In order to evaluate the utility of 6-TU and 6-MP plasma concentrations in monitoring AZA therapy, we studied their pharmacokinetics in 6 renal transplant patients, and their in vitro immunosuppressive potency in a mixed lymphocyte proliferation assay. A peak plasma 6-TU concentration of 710.7 ng/ml was observed at 3.8 h after oral dosing. Good correlation was observed between the elimination t1/2 of 6-TU and serum creatinine, and between AUC over 24 h and serum creatinine. However, we did not observe a second peak in plasma 6-TU concentration that could be attributed to the degradation of active AZA metabolites. 6-MP plasma concentrations in the patients were low (mean peak concentration 36.0 ng/ml) and rapidly disappeared within 8 h. In vitro immunosuppressive activity could not be demonstrated for 6-TU over a concentration range of 1.25 ng/ml to 0.25 mg/ml. We conclude that 6-TU is pharmacologically inert and is primarily eliminated by the kidneys. Our findings currently do not support the use of plasma concentrations of 6-TU or 6-MP to monitor AZA therapy. In order to optimize AZA therapy, analytical techniques that are technically feasible and that can directly quantify the active intracellular thiopurines are being explored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558158
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Rheological measurements and light-scattering experiments of dilute solutions of high molecular polystyrene. Light-scattering of flowing polymer solutions (1991)
    Springer
    Colloid & polymer science 269 (1991), S. 1250-1256 
    Details
    ISSN: 1435-1536
    Keywords: Light-scattering ; flowing polymer solution ; dilute polymer solution ; orientation and deformation of macromolecules ; polystyrene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract We describe the behavior of dilute polymer solutions by means of light-scattering under shear flow. Solution properties of polystyrene in benzene over a wide range of molecular weight has been studied to determine the coefficientsa andK of the Mark-Houwink relationship and to estimate the rheological conditions with regard to light-scattering experiments of flowing polymer solutions. The investigations were carried out to measure the shear-rate dependence of macromolecules in solution, e.g., to observe an orientation and changing of the mean-square radius of gyration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00652533
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  • 3
    Electronic Resource
    Electronic Resource
    Analysis of Taylor vortex flow by means of laser light scattering (1992)
    Springer
    Rheologica acta 31 (1992), S. 274-282 
    Details
    ISSN: 1435-1528
    Keywords: Light-scattering ; flowing polymer solution ; dilute polystyrene solution ; Taylor-vortex ; solvent power
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Abstract Rheological measurements and light-scattering experiments were performed on dilute solutions of high molecular polystyrene. We are able to describe the orientation behavior of chain molecules under shear flow by means of light-scattering. Beyond that these investigations of light-scattering of flowing polymer solutions are an useful and suitable tool for detection and characterization of Taylor vortex formation. We can estimate the appearance of these hydrodynamic instabilities, which overlay the laminar main flow and we can observe a typical influence of the solvent power on it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00366506
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  • 4
    Electronic Resource
    Electronic Resource
    Copepoda Poecilostomatoida associated with Bivalvia from New Guinea (1995)
    Springer
    Hydrobiologia 312 (1995), S. 37-45 
    Details
    ISSN: 1573-5117
    Keywords: Copepoda ; Bivalvia ; New Guinea ; Pseudanthessius ; Lichomolgus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Four species of Copepoda Poecilostomatoida are recorded from the mantle cavity of bivalve molluscs collected in West New Guinea (Irian Barat, Indonesia). Two of these are new to science: Pseudanthessius dimorphus and Lichomolgus hoi n. spp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00018885
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  • 5
    Electronic Resource
    Electronic Resource
    Copepods associated with reef corals: a comparison between the Atlantic and the Pacific (1988)
    Springer
    Hydrobiologia 167-168 (1988), S. 545-547 
    Details
    ISSN: 1573-5117
    Keywords: Copepoda ; endoassociates ; corals ; biogeography ; tropical Atlantic ; Pacific
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Endoparasitic copepods are very numerous in Indo-West Pacific corals. In West Indian corals they were thought to be absent, but recent studies have shown that a varied endoparasitic copepod fauna exists as well. Striking is the taxonomic composition of the coral-inhabiting copepods: In the Indo-West Pacific Lichomolgidae and Xarifiidae are the dominant families, both are absent in the West Indies. On the other hand, Corallovexiidae and Asterocheridae dominate in the West Indies; the former family is absent and the latter is apparently rare and not very diversified in the Indo-West Pacific.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00026350
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