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  • Oxford University Press  (20)
  • American Geophysical Union  (5)
  • Inter-Research  (4)
  • Wiley-Blackwell  (4)
  • International Union of Crystallography (IUCr)
  • Nature Publishing Group
  • 1
    Electronic Resource
    Electronic Resource
    Experimental investigation of geologically produced antineutrinos with KamLAND (2005)
    [s.l.] : Nature Publishing Group
    Nature 436 (2005), S. 499-503 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The detection of electron antineutrinos produced by natural radioactivity in the Earth could yield important geophysical information. The Kamioka liquid scintillator antineutrino detector (KamLAND) has the sensitivity to detect electron antineutrinos produced by the decay of 238U and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature03980
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  • 2
    Electronic Resource
    Electronic Resource
    Structure of a binuclear [(1R,2R)-N,N'-disalicylidene-1,2-cyclohexanediamine]titanium(IV) complex (1988)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 44 (1988), S. 1309-1311 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270188003464
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  • 3
    Electronic Resource
    Electronic Resource
    Studies on 2-aziridinecarboxylic acid peptides: Their reaction and uses (1981)
    New York : Wiley-Blackwell
    Biopolymers 20 (1981), S. 1811-1821 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The reaction of 2-aziridinecarboxylic acid derivatives with several protic reagents was used to synthesize depsipeptides, dehydroamino acid derivatives, diaminopropionic acid derivatives, and phospho peptide derivatives. The reaction of N-aminoacyl-2-aziridinecarboxylic acid benzyl ester with amino acid ester induced stereoselective transacylation.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1981.360200906
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  • 4
    Electronic Resource
    Electronic Resource
    Acid-base surface properties of modified poly(ethylene terephthalate) films and gelatin: Relationship to adhesion (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 42 (1991), S. 2825-2831 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Characterization of poly(ethylene terephthalate) (PET) films surfaces through wettability measurements and inverse gas chromatography techniques leads to a better knowledge of the potential interactions with a coating. An important case is the one relative to gelatin coatings for photographic films. In order to favor adhesion on PET, it is of interest to examine the problem in terms of acid-base interactions. PET is found amphoteric and gelatin rather basic. Several surface treatments on PET like orientation on water and flame or plasma treatment in air lead to an increase in surface acidity. Adhesion with gelatin as determined by the peel test is increased through a flame treatment, because of the higher acidity of PET and subsequent chemical bonding at the interface. Determination of acid-base surface properties of PET and gelatin appears to be an excellent tool for adhesion prediction.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1991.070421021
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of an electric field on polar-group orientation and adhesion at poly(ethylene terephthalate) surfaces (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 46 (1992), S. 1045-1050 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Application of a high continuous electrical field accelerates the orientation kinetics of polar groups at a polymer-water interface and so improves the surface polarity. This is preliminary to adhesion establishment on a polar substrate. Adhesion of PET and gelatin performed under an electric field leads to an increase of the interfacial adhesion properties, due to simultaneous effects of the electric field at the interface. Polar-group orientation at a polymer surface and electrical aspects of adhesion are therefore self-consistent.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1992.070460613
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  • 6
    Electronic Resource
    Electronic Resource
    Plasma polymerization of tetrafluoroethylene (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 23 (1979), S. 2627-2637 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The plasma polymerization of C2F4 was carried out in both continuous wave and pulsed rf discharges to establish the effects of reaction conditions on the kinetics of polymer deposition and the polymer structure. ESCA spectra of the polymer show evidence for —CF3, —CF2, and —CH2— groups. Under conditions favoring low deposition rates, the dominant functional group is —CF2—. At higher deposition rates the concentration of —CF2— groups is reduced and a more crosslinked polymer is produced. Both polymer deposition rates and polymer structures were essentially identical when using continuous wave and pulsed rf discharges.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1979.070230908
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  • 7
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    Early Science with the Large Millimeter Telescope: observations of dust continuum and CO emission lines of cluster-lensed submillimetre galaxies at z=2.0-4.7 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-07-16
    Description: We present Early Science observations with the Large Millimeter Telescope, AzTEC 1.1 mm continuum images and wide bandwidth spectra (73–111 GHz) acquired with the Redshift Search Receiver, towards four bright lensed submillimetre galaxies identified through the Herschel Lensing Survey-snapshot and the Submillimetre Common-User Bolometer Array-2 Cluster Snapshot Survey. This pilot project studies the star formation history and the physical properties of the molecular gas and dust content of the highest redshift galaxies identified through the benefits of gravitational magnification. We robustly detect dust continuum emission for the full sample and CO emission lines for three of the targets. We find that one source shows spectroscopic multiplicity and is a blend of three galaxies at different redshifts ( z  = 2.040, 3.252, and 4.680), reminiscent of previous high-resolution imaging follow-up of unlensed submillimetre galaxies, but with a completely different search method, that confirm recent theoretical predictions of physically unassociated blended galaxies. Identifying the detected lines as 12 CO ( J up  = 2–5) we derive spectroscopic redshifts, molecular gas masses, and dust masses from the continuum emission. The mean H 2 gas mass of the full sample is (2.0 ± 0.2)  x  10 11 M /μ, and the mean dust mass is (2.0 ± 0.2)  x  10 9 M /μ, where μ  2–5 is the expected lens amplification. Using these independent estimations we infer a gas-to-dust ratio of GDR   55–75, in agreement with other measurements of submillimetre galaxies. Our magnified high-luminosity galaxies fall on the same locus as other high-redshift submillimetre galaxies, extending the $L^{\prime }_{\rm CO}$ – L FIR correlation observed for local luminous and ultraluminous infrared galaxies to higher far-infrared and CO luminosities.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 8
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    Translational regulation by the 5'-UTR of thyroid hormone receptor {alpha} mRNA (2012)
    Oxford University Press
    Details
    Publication Date: 2012-04-27
    Description: Thyroid hormone (TH) regulates gene transcription by binding to the thyroid hormone receptor (TR) and plays a critical role in the regulation of development, growth and metabolism. The ligated TR activates many effector genes, which contributes to the orchestrated remodelling of the amphibian metamorphosis. However, the mechanisms regulating TRα protein level remain unknown. We determined the nucleotide sequences of the 5'-untranslated regions (5'-UTRs) in amphibian TRα mRNAs. The TRα 5'-UTR contains evolutionarily conserved regions. We demonstrated that a 161-nt stretch of the Xenopus TRα 5'-UTR strongly represses the translation of the downstream open reading frame in both frog and human cell lines, as well as in a cell-free translation system. An analysis using successive deletions of the TRα 5'-UTR revealed five elements possessing translational repressive activity. We analysed two elements, the 14-nt GC-rich region and the 15-nt upstream open reading frame (uORF), by introducing point mutations. This analysis showed that the GC-rich region, which shares its nucleotide sequence with the Sp1-binding site, requires stringent sequence specificity at a nucleotide level for translational repression to take place, whereas under our study conditions, the uORF does not. This study provides an example of complex translational regulation by multiple elements.
    Print ISSN: 0021-924X
    Electronic ISSN: 1756-2651
    Topics: Biology , Chemistry and Pharmacology
    Published by Oxford University Press on behalf of The Japanese Biochemical Society (JBS).
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  • 9
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    Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2 (2014)
    Oxford University Press
    Details
    Publication Date: 2014-09-04
    Description: Myelin, a multilamellar structure extended from oligodendrocytes or Schwann cells, plays a critical role in maintenance of neuronal function, and damage or loss of myelin causes demyelinating diseases such as multiple sclerosis. For precise alignment of the myelin sheath, there is a requirement for expression of galactosylceramide (GalCer), a major glycosphingolipid in myelin. Synthesis of GalCer is strictly limited in oligodendrocytes in a developmental stage-specific manner. Ceramide galactosyltransferase (CGT), a key enzyme for biosynthesis of GalCer, exhibits restricted expression in oligodendrocytes but the mechanism is poorly understood. Based on our assumption that particular oligodendrocyte-lineage-specific transcription factors regulate CGT expression, we co-expressed a series of candidate transcription factors with the human CGT promoter-driving luciferase expression in oligodendroglioma cells to measure the promoter activity. We found that Nkx2.2 strongly activated the CGT promoter. In addition, we identified a novel repressive DNA element in the first intron of CGT and OLIG2, an oligodendrocyte-specific transcription factor, as a binding protein of this element. Moreover, overexpression of OLIG2 completely canceled the activating effect of Nkx2.2 on CGT promoter activity. Expression of CGT mRNA was also upregulated by Nkx2.2, but this upregulation was cancelled by co-expression of OLIG2 with Nkx2.2. Our study suggests that CGT expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners.
    Print ISSN: 0959-6658
    Electronic ISSN: 1460-2423
    Topics: Biology , Medicine
    Published by Oxford University Press
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  • 10
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    Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS (2015)
    Oxford University Press
    Details
    Publication Date: 2015-02-26
    Description: The expansion of the GGGGCC hexanucleotide repeat in the non-coding region of the chromosome 9 open-reading frame 72 ( C9orf72 ) gene is the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) (c9FTD/ALS). Recently, it was reported that an unconventional mechanism of repeat-associated non-ATG (RAN) translation arises from C9orf72 expansion. Sense and anti-sense transcripts of the expanded C9orf72 repeat, i.e. the dipeptide repeat protein (DRP) of glycine–alanine (poly-GA), glycine–proline (poly-GP), glycine–arginine (poly-GR), proline–arginine (poly-PR) and proline–alanine (poly-PA), are deposited in the brains of patients with c9FTD/ALS. However, the pathological significance of RAN-translated peptides remains unknown. We generated synthetic cDNAs encoding 100 repeats of DRP without a GGGGCC repeat and evaluated the effects of these proteins on cultured cells and cortical neurons in vivo. Our results revealed that the poly-GA protein formed highly aggregated ubiquitin/p62-positive inclusion bodies in neuronal cells. In contrast, the highly basic proteins poly-GR and PR also formed unique ubiquitin/p62-negative cytoplasmic inclusions, which co-localized with the components of RNA granules. The evaluation of cytotoxicity revealed that overexpressed poly-GA, poly-GP and poly-GR increased the substrates of the ubiquitin–proteasome system (UPS), including TDP-43, and enhanced the sensitivity to a proteasome inhibitor, indicating that these DRPs are cytotoxic, possibly via UPS dysfunction. The present data indicate that a gain-of-function mechanism of toxic DRPs possibly contributes to pathogenesis in c9FTD/ALS and that DRPs may serve as novel therapeutic targets in c9FTD/ALS.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
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