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  • Institute of Physics  (157)
  • Springer  (102)
  • PANGAEA  (22)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 277 (1976), S. 351-356 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The levels in the ground band of184Pt are identified up to the member with spin 20 in an in-beam spectroscopy experiment on theγ-rays following the177Hf(12C, 5n)184Pt reaction. In contrast to the situation in the heavier Pt isotopes, where the 10+ to 12+ level spacing is very small, the transition energies in184Pt show a monotonie increase with spin. However, between spin 10+ and 14+ the moment of inertia grows quite rapidly and this appears to be reminiscent of the much more pronounced irregularity encountered in the isotopes of larger mass. This property of the moment of inertia is discussed within a model where twoi 13/2 neutron quasiparticles or twoh 9/2 orh 11/2 proton quasiparticles may be excited and coupled to the rotation of the core.
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  • 2
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The 5→4 and 4→3 transitions in muonic Pb and Ba, respectively, were measured with an accuracy of ∼10eV. Agreement with theoretical calculations is established. The vacuum polarization is tested to 3×10−3, and vacuum polarization corrections of higher order in (αZ) to 20–30%.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 290 (1979), S. 265-268 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The halflife of the 9/2 1 + , 53.2 keV state in105Ag has been measured by the delayed-coincidences technique to 2.33±0.08 ns. The reduced transition probabilities between the 9/2 1 + and 7/2 1 + states have been deduced and compared with the theoretical predictions within the cluster-vibration coupling model (Alaga model).
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 283 (1977), S. 357-361 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The directional correlations ofγ-γ andγ-electron cascades in119Sb are measured, in the decay of119mTe. Bothγ-γ andγ-electron directional correlation coefficients are determined for the cascades (energies in keV): 153.5-1212.7, 942.3-270.5, (976.2+979.3)-270.5, 1095.7-270.5 and 1136.8-270.5. For the cascades 912.6-1366.2, 2013.4-270.5 and 2089.9-270.5γ-γ directional correlations are measured. The mixing ratios evaluated are:δ(M2/E1, 153.5 keV)=0.0003±0.0023,δ(E2/M1, 270.5 keV)=-0.39±0.29,δ(E2/M1, 942.3 keV)= −0.26±0.12,δ(E3/M2,1095.7 keV)=−0.01±0.07, andδ(M3/E2,1212.7 keV) =0.004±0.007. The result is compared with theoretical predictions.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 276 (1976), S. 381-391 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The de-excitation of levels in119–125Sn populated in the decay of In isotopes has been studied using on-line isotope separators. Level half-lives have been measured in119–123Sn. a near cancellation of the matrix element for B(E2; g7/2→ d3/2) is observed to occur in121Sn and is probably due to pairing effects. Very low lying 9/2− levels have been observed in121–125Sn and are suggested in127, 129Sn. These levels have been interpreted as three quasi-particle states based on the unique parity h11/2 level. A possible mixing of theg 7/2 level with a close lying 7/2+ three quasi-particle state in123Sn is discussed. Radioactivity.119–125In from235U(n, f) and238U(α, f), isotope separated sources; measuredE γ ,I γ , Ece, Ice,γγ-coin,Βγ-delay, deduced multipolarities.119–123Sn deduced levels,I, π, B(λ). Ge(Li), Si(Li), NaI(Tl) and plastic detectors, Ge(Li)-Ge(Li) coin, plastic detector — NaI(Tl) delay.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 305 (1982), S. 87-88 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The rotational properties of the odd-odd168Tm have been studies by means of the165Ho(α, 3n)166Tm reaction. The existence of five rotational bands has been established.
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  • 7
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Genomic sequencing was combined with searches of databases for identification of active genes on human chromosome 22. A cosmid from 22q13, located in the telomeric vicinity of the PDGFB (platelet-derived growth factor B-chain) gene, was fully sequenced. Using an expressed sequence tag-based approach we characterized human (SYNGR1) and mouse (Syngr1) orthologs of the previously cloned rat synaptogyrin gene (RATSYNGR1). The human SYNGR1 gene reveals three (SYNGR1a, SYNGR1b, SYNGR1c) alternative transcript forms of 4.5, 1.3 and 0.9 kb, respectively. The transcription of SYNGR1 starts from two different promoters, and leads to predicted proteins with different N- and C-terminal ends. The most abundant SYNGR1a transcript, the 4.5-kb form, which corresponds to RATSYNGR1, is highly expressed in neurons of the central nervous system and at much lower levels in other tissues, as determined by in situ hybridization histochemistry. The levels of SYNGR1b and SYNGR1c transcripts are low and limited to heart, skeletal muscle, ovary and fetal liver. We also characterized two additional members of this novel synaptogyrin gene family in human (SYNGR2 and SYNGR3), and one in mouse (Syngr2). The human SYNGR2 gene transcript of 1.6 kb is expressed at high levels in all tissues, except brain. The 2.2-kb SYNGR3 transcript was detected in brain and placenta only. The human SYNGR2 and SYNGR3 genes were mapped by fluorescence in situ hybridization to 17qtel and 16ptel, respectively. The human SYNGR2 gene has a processed pseudogene localized in 15q11. All predicted synaptogyrin proteins contain four strongly conserved transmembrane domains, which is consistent with the M-shaped topology. The C-terminal polypeptide ends are variable in length, display a low degree of sequence similarity between family members, and are therefore likely to convey the functional specificity of each protein.
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  • 8
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Chromosomal deletions on 3p have been described in a large number of human tumors, suggesting the presence of a tumor suppressor gene(s). Using an experimental system, called the elimination test, we previously identified a 1 Mb segment, the common eliminated region 1 (C3CER1). C3CER1 was also covered by a PAC contig. Using the sequence of two overlapping PACs from C3CER1, we localized the human KIAA0028 cDNA, encoding the precursor of mitochondrial leucyl-tRNA synthetase. We also characterized a novel human LIM domain-containing gene (LIMD1) and its mouse ortholog (Limd1). LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. The predicted protein sequences of the human and mouse genes reveal three LIM domains located at the C-terminal end, which indicates that they belong to the group 3 of the gene family encoding LIM motifs. We characterized the genomic structure of the human LIMD1 gene and assigned the mouse Limd1 gene to the chromosome 9F subtelomeric region. Both genes are ubiquitously expressed at the mRNA level. The LIM motif has been previously identified in many developmentally important factors from various eukaryotes. These factors have been shown to play a role in intracellular signaling, transcriptional regulation and cellular differentiation during development. The human C3CER1-located LIMD1 gene should therefore be further studied for its possible role in tumor suppression.
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  • 9
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Multiple endocrine neoplasia type 1 (MEN1) is tightly linked to the muscle-type glycogen phosphorylase (PYGM) gene in 11q13. This region of the human genome contains additional disease-related loci implicated in the development of insulin-dependent diabetes mellitus, familial paraganglioma type 2, spinocerebellar ataxia type 5, Bardet-Biedl syndrome and translocation t(11;17) described in B-cell non-Hodgkin’s lymphoma. We approached cloning of candidate disease genes from 11q13 by large-scale genomic sequencing. We obtained 〉 106 kb of sequence around the PYGM gene and established a transcriptional map that includes: (i) two genes previously localized to 11q13, PYGM and a zinc-finger protein (ZFM1) gene; (ii) the germinal center kinase (GCK, human B-lymphocyte serine/threonine protein kinase) gene; (iii) a novel human CDC25-like (HCDC25L) gene; (iv) a dystrophia myotonica protein kinase-like (DMPKL) gene; and (v) a novel ubiquitously expressed gene of unknown function (germinal center kinase- neighboring gene, GCKNG).
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 21 (1982), S. 325-330 
    ISSN: 1432-1041
    Keywords: cimetidine ; renal failure ; cimetidine sulphoxide ; pharmacokinetics ; haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A single intravenous dose of cimetidine 200mg was administered to 6 patients with severe chronic renal failure one hour prior to haemodialysis. The plasma concentrations of cimetidine and its sulphoxide metabolite at the start of haemodialysis were 2.74±0.12 and 0.76±0.08 µg/ml, and after dialysis for 4h 1.08±0.10 and 0.51±0.08 µg/ml, respectively (mean ± SE). The average haemodialysis clearance (ClHDa) of cimetidine during dialysis was 46–92ml/min at a dialysate flow rate of 320ml/min and blood flow rates in the 6 patients between 160–240ml/min. The mean ClHDa of the sulphoxide metabolite was 44% higher than that of cimetidine, and ranged between 49–148ml/min. During haemodialysis the mean plasma elimination half-life (t1/2) of cimetidine was 3.24h (range 2.08–5.08) and of the sulphoxide metabolite 9.49h (range 4.70–14.39). There was a significant relationship between the elimination rate constant (β) and ClHDa of the sulphoxide metabolite (p〈0.01), but no such relationship was found between β and ClHDa of cimetidine. However, there was a tendency to a relationship between β of cimetidine and the capacity to metabolise the drug, expressed as the ratio between the plasma concentrations of the sulphoxide metabolite and cimetidine after dialysis for 4h. These ratios ranged between 0.23–0.76, and the lowest ratio was seen in the patient with the lowest β value of cimetidine. Thus, the large variations in the plained by differences in their capacity to metabolise the drug. The mean total amount of cimetidine eliminated during dialysis was 27.3mg (range 17.9–31.8), which was 9.0–15.9% of the given dose. Between 12.2–21.2mg (mean 15.3) of the sulphoxide metabolite was eliminated in the dialysate. Major adjustment of the dose of cimetidine on days of dialysis is not necessary.
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