Publication Date:
2016-01-27
Description:
Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good. This approach represents a step-economical path to enantiomerically pure, polyfunctionalized peptidomimetics endowed with three stereogenic centers, allowing the introduction of five diversity inputs. Beilstein J. Org. Chem. 2016, 12, 139–143. doi:10.3762/bjoc.12.15
Keywords:
aminoalcoholsisocyanidesmulticomponent reactionspeptidomimeticsUgi reaction
Electronic ISSN:
1860-5397
Topics:
Chemistry and Pharmacology
Permalink