Publication Date:
2015-04-23
Description:
Article STIM proteins sense calcium depletion in the endoplasmic reticulum and in response activate calcium influx through Orai1 channels located at the plasma membrane. Here, Miederer et al . identify a novel splice variant of STIM2 that fails to interact with and activate Orai1 and may act to fine-tune cellular calcium homeostasis by negatively regulating calcium influx. Nature Communications doi: 10.1038/ncomms7899 Authors: Anna-Maria Miederer, Dalia Alansary, Gertrud Schwär, Po-Hsien Lee, Martin Jung, Volkhard Helms, Barbara A. Niemeyer
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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