ISSN:
1572-8773
Keywords:
Hemocyanin
;
Allostery
;
Nested MWC model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Summary When the oxygen binding of the hemocyanin from the lobsterHomarus americanus was analysed in terms of the nested Monod-Wyman-Changeux model, it revealed that protons affect the allosteric equilibria between four conformations. Applying computer simulations we have demonstrated the specific influence of the three different allosteric equilibrium constants on the affinity and cooperativity of oxygen binding.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01179509
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