ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Notes and Correspondence: The Sulfuric Acid Industry (1918)

Goodwin, C.

s.l. : American Chemical Society

Industrial & engineering chemistry 10 (1918), S. 751-752

add to mindlist on the mindlist

Details

ISSN: 1520-5045

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1021/ie50105a600

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

A comparison between two methacrylate cements as delivery systems for bioactive human growth hormone (1995)

Goodwin, C. J. ; Braden, M. ; Downes, S. ; [et al.]

Springer

Journal of materials science 6 (1995), S. 590-596

add to mindlist on the mindlist

Details

ISSN: 1573-4838

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine , Technology

Notes: Two methacrylate orthopaedic bone cements were compared as delivery systems for bioactive human growth hormone (hGH). These were London Hospital Bone Cement (LHBC) and a poly(methylmethacrylate) (PMMA) bone cement. A uniquely precise bioassay for hGH, named ESTA, was used. It was adapted to assess both the bioactivity of the hormone released from hGH loaded cements and also the in vitro cytotoxicity of the cements themselves. Eluates from both cements proved cytotoxic, this being most pronounced for LHBC. The cytotoxicity could be readily diluted out, and a lengthy exposure time (〉 24 h) was required to kill the cells. Both cements released similar quantities of bioactive hGH, which were ∼0.6% of that originally incorporated. This could potentially provide significantly high local concentrations of the hormone to the tissues surrounding the implant. Approximately double quantities of hormone were released as measured by immunoassay, leading to significant decreases (p=〈0.0001) in the B:I ratios of the released hormone. The effect was greatest for LHBC. Our results suggest that the structural integrity of the hGH molecules released from LHBC were the most compromised.