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  • Articles  (116)
  • Springer  (99)
  • American Chemical Society  (17)
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  • Articles  (116)
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  • 11
    Electronic Resource
    Electronic Resource
    Nucleotide sequence of the humanθ 1-globin gene (1988)
    Springer
    Biochemical genetics 26 (1988), S. 207-211 
    Details
    ISSN: 1573-4927
    Keywords: DNA sequence ; human θ1-globin gene ; cloning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We have cloned and sequenced the human θ1-globin gene. The nucleotide sequence and organization of the human θ1 gene (exons, introns, promoter, and polyadenylation signals) are similar to those reported for the orangutan θ1-globin gene. If these genes are functional, the sequences of their θ1-globin chains would differ by only one amino acid residue (at position 137).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561460
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  • 12
    Electronic Resource
    Electronic Resource
    Structural shape optimization integrated with CAD environment (1990)
    Springer
    Structural and multidisciplinary optimization 2 (1990), S. 23-28 
    Details
    ISSN: 1615-1488
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The research work presented here is based on the concept of the integration of optimization techniques and numerical analysis with the finite element method (FEM) and computer-aided design (CAD). A microcomputer aided optimum design system, MCADS, has been developed for general structures. Certain techniques to be discussed in the paper, e.g. the semi-analytical method for design sensitivity analysis, optimization analysis modelling for shape design, application oriented user interfaces and the coupling of automated optimization and user intervention have rendered MCADS pratical and versatile in applications for engineering structures. The above techniques and an application are presented in this paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01743517
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  • 13
    Electronic Resource
    Electronic Resource
    Structural modelling and sensitivity analysis of shape optimization (1993)
    Springer
    Structural and multidisciplinary optimization 6 (1993), S. 29-37 
    Details
    ISSN: 1615-1488
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract It is presented in this paper that the structural modelling of shape optimization is composed of, in general cases, four distinct processes on geometry, design, analysis and perturbation models. The relationships between these models are discussed. An integrated modelling approach based on geometric shape parameterization and automatic mesh generation is proposed. In cooperation with this modelling approach, the semi-analytic sensitivity analysis has been effectively employed. These techniques join shape optimization with FEM and CAD packages and apply it versatilely to optimum designs of general structures. The implementation and applications of the integrated modelling approach and semi-analytic sensitivity analysis to shape optimization of structures with coupling of stress and temperature fields are illustrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01743172
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  • 14
    Electronic Resource
    Electronic Resource
    Induction of apoptosis in proliferating lymphocytes by tricyclic antidepressants (1998)
    Springer
    Apoptosis 3 (1998), S. 255-260 
    Details
    ISSN: 1573-675X
    Keywords: Antidepressants ; apoptosis ; induction ; lymphoblasts ; lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have previously found that tricyclic antidepressants (TCAs) induce apoptosis in quiescent human lymphocytes. The aim of the present study was to evaluate if TCAs induce apoptosis in proliferating human lymphocytes and in established blastoid lymphocytes also. The development of conA-induced lymphoblast populations was followed by measuring the CD25 membrane expression. Three TCA compounds were run with the following concentrations: imipramine (10, 20, 30, 40, 60μ M), clomipramine (1, 10, 20, 30, 40μ M) and citalopram (40, 60, 80, 100, 180μ M). They all induced a dose-dependent apoptosis both in continuously transformed, as well as in established lymphoblasts. Preincubation of the TCA up to 48 h did not significantly increase induction of apoptosis. The three drugs tested were found to be potent inducers of apoptosis in proliferating lymphocytes. Furthermore, we found that the apoptotic populations in proliferating and in established blastoid lymphocytes were of f airly the same magnitude than in the corresponding population in TCA-incubated resting lymphocytes. In conclusion, we demonstrate that TCAs induce apoptosis in proliferating lymphocytes, as they do in quiescent lymphocytes. Furthermore, the exent of apoptosis was even more pronounced in TCA-incubated lymphoblasts compared to TCA-treated resting lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009609224936
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  • 15
    Electronic Resource
    Electronic Resource
    Carbon nitride films prepared by ion implantation (1996)
    Springer
    Journal of materials science 15 (1996), S. 1355-1357 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00240806
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  • 16
    Electronic Resource
    Electronic Resource
    Dielectric resonance, local field distribution, and optical response in 3D resonant composites (2004)
    Springer
    The European physical journal 42 (2004), S. 165-173 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. We extend the Green’s function formalism in a binary 2D composite to 3D. Using the formalism, we investigate the dielectric resonances, local-field distribution, and effective linear optical responses for one-bond, two-bond and three-bond clusters, as well as for various disordered composites. Due to the different values of Green’s function in 2D and 3D, for the same cluster, the values of the dielectric resonances in 3D are smaller than those in 2D, but the fields are more localized than those in 2D. The sum rule of dielectric resonance in three-component composites is extended to d dimensions. For the same resonance, the intensity of the local-field in 3D is also weaker than that in the 2D case, but the fields are more localized than those in 2D. For the disordered composites in 2D and 3D, inverse participation ratios (IPR) with q = 2 are used to represent the localization of the field. When we increase the concentration of impurity bonds, a blue shift of IPR peaks occurs in 3D, while in 2D, these peaks are very stable. Finally, both for 2D and 3D disordered composites, the absorption range broadens with increasing impurity concentration, and a red shift of the absorption peak is observed in 3D.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjb/e2004-00368-5
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  • 17
    Electronic Resource
    Electronic Resource
    Analysis of Two-Dimensional Effect in the Measurement of Thermal Diffusivity of Thin Films with an AC Calorimetric Method1 (2000)
    Springer
    International journal of thermophysics 21 (2000), S. 525-534 
    Details
    ISSN: 1572-9567
    Keywords: ac calorimetric method ; thermal diffusivity ; thin film ; two-dimensional effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract An ac calorimetric method for measuring the thermal diffusivity of thin-film materials has been widely applied. In the application of this method, the systematic errors caused by the heat loss effect, the edge reflection effect, etc., have been analyzed and corresponding correction methods have been developed. But when measuring films with low thermal diffusivity or with thickness comparable to the thermal diffusion length, a two-dimensional effect which will also result in a systematic error of the measurement is present. In this paper, the mechanism of two-dimensional heat conduction within a thin sample which is supplied a periodic heat flux by a chopped light beam is analyzed. A numerical analysis method is developed to study the effect of the two-dimensional heat conduction on the measured thermal diffusivity values. The relations between the measured thermal diffusivity and independent parameters such as frequency, thickness of sample, width of light spot, etc., are demonstrated to indicate the two-dimensional effect. The experimental precondition for minimizing the systematic error caused by the two-dimensional effect is determined. In addition, the analysis method presented in this paper should be useful for more difficult problems such as error estimation of the thermal diffusivity measurement of coatings or composite films.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006608302119
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  • 18
    Electronic Resource
    Electronic Resource
    Correction of Edge Effect in AC Calorimetric Method for Measuring Thermal Diffusivity of CVD Diamond Films1 (2000)
    Springer
    International journal of thermophysics 21 (2000), S. 487-493 
    Details
    ISSN: 1572-9567
    Keywords: ac calorimetric method ; CVD diamond film ; edge effect ; parameter estimation ; thermal diffusivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In the thermal diffusivity measurement of a CVD diamond film using an ac calorimetric method, the reflection of an ac temperature wave at the edge of the film sample should be considered due to the limited length of the sample and its high thermal diffusivity, i.e., the edge effect. In this case, the measured thermal diffusivity is given as a function of frequency. The relation between the measured thermal diffusivity and the frequency is represented as an analytical expression. The real thermal diffusivity is obtained by correcting the edge effect by two means. One is an iterative method using the directly measured edge length of the sample to fit the analytical expression. The other is a parameter estimation method by which a simplex method is used to estimate the edge length and the real thermal diffusivity. Thermal diffusivities of two diamond films were measured, and data were analyzed using the above methods. The result shows that the parameter estimation method is relatively accurate and convenient in processing test data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006600100302
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  • 19
    Electronic Resource
    Electronic Resource
    Crystalline β-C3N4 synthesized by MPCVD (1999)
    Springer
    Journal of materials science 34 (1999), S. 3117-3125 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Carbon nitride films were grown on Si and Pt substrates by microwave plasma chemical vapor deposition (MPCVD) method. Scanning electron microscope (SEM) observations show that the films deposited on Si substrates consisted of densely populated hexagonal crystalline rods. Energy dispersive X-ray (EDX) analyses show that N/C ratios of the rods were in the range of 1.0 to 2.0 depending on deposition condition. X-ray diffraction experiments show that the films consisted of crystalline phase β-C3N4. Comparison with films grown on Pt substrate show that the main X-ray diffraction peaks of β-C3N4 are existed in films deposited on both substrate. XPS study showed that carbon and nitride atoms are covalent bounded to each other. IR results show that the film is predominantly C-N bonded. Raman measurement showed characteristic peaks of β-C3N4 in the low wave number region. Temperature dependent growth experiments show that the amount of Si3N4 in the films grown on Si substrates can be significantly reduced to negligible amount by controlling the substrate temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004609218229
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  • 20
    Electronic Resource
    Electronic Resource
    In vitro uptake and autoradiographic localization of tritiated gossypol inTaenia taeniaeformis metacestodes (1993)
    Springer
    Parasitology research 79 (1993), S. 279-285 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Gossypol, a natural polyphenolic compound, induces growth-inhibitory and antiparasitic effects inTaenia taeniaeformis metacestodes in vivo and in vitro. We investigated the uptake and localization of [3H]-gossypol in this parasite. Metacestodes were incubated in 10−5 M [3H]-gossypol at 37°C. Parasites steadily took up tritium activity over the first 3 h of incubation, after which a plateau was maintained for the duration of the experiment. Tissue: medium radioactivity ratios revealed that intralarval tritium activity matched extralarval activity within 30 min of incubation and continued to increase with time. Reverse-phase high-performance liquid chromatographic (HPLC) analysis confirmed tissue incorporation of tritium activity that manifested as a single radioactive species. Autoradiography localized [3H]-gossypol to the tegument, calcareous corpuscles, and parenchyma over the first 2 h of incubation. By 6 h, parenchymal radioactivity had disappeared.T. taeniaeformis metacestodes rapidly take up and accumulate [3H]-gossypol in vitro. This accumulation is apparently selective for specific sites, which may have implications for gossypol's metacestocidal action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00932182
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