ISSN:
1476-5535
Keywords:
Sterilization
;
Bioreactor
;
Computer
;
F 0
;
Voice synthesizer
;
Thermal input
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary Industrial fermentation media are normally sterilized with steam to destroy the indigenous microbial population prior to inoculation with a specific microorganism. Because biological validation of each sterilization cycle is impractical, an ‘overkill’ approach is commonly employed on the basis that alteration of heat-sensitive nutrients is less detrimental than survival of indigenous microbes. However, the heat destruction of microbes is known to be a probability function amenable to calculation. A computer has been programmed to calculate the on-line heat input asF 0 values during sterilization of media in stirred bioreactors. The accumulation ofF 0 values is then announced verbally to bioreactor operators by a communications controller with voice synthesizer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01569531
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