ISSN:
1432-1041
Keywords:
Key words LIPO-Prostaglandin E1; intermittent claudication
;
haemodynamics
;
quantitative blood flow measurement
;
transcutaneous oxygen pressure
;
walking distance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: We compared the efficacy of a bolus injection (5 min) of LIPO-PGE1 (Prostaglandin E1 in lipid emulsion) with conventional PGE1-cyclodextrin (PGE1-cyclodextrin) infusions (2 h) in patients with intermittent claudication. The quantitative blood-flow in the common femoral artery was measured using a computerized ultrasound Doppler system (MAVIS®). we also monitored the transcutaneous oxygen pressure, the skin temperature on the foot, and the reactive change in blood pressure and pulse as well as side effects. Results : Dose finding of LIPO-PGE1: After bolus injection of 30, 50, and 80 μg LIPO-PGE1 a significant dose-dependent increase of the blood flow in the leg (+ 96.9%, 80 μg) with a peak 3 h after injection was seen. After LIPO-PGE1 we observed an enhanced microcirculation (significant rise in the transcutaneous oxygen pressure and the skin temperature on the foot). We noted longer lasting pharmacodynamic properties with LIPO-PGE1 (50 μg) compared to PGE1-cyclodextrin (60 μg). Comparison to PGE1-cyclodextrin: In a cross-over, placebo-controlled study, 20 patients with intermittent claudication received 4 weeks therapy with a bolus of 50 μg LIPO-PGE1 or a 2 h infusion of 60 μg PGE1-cyclodextrin per day. A significant increase in the blood flow was measured at the end of 4 weeks therapy compared to the initial values before treatment. This rise correlates significantly with the increase in the patient’s maximal walking distance (+112%, LIPO-PGE1). Compared to conventional PGE1-cyclodextrin infusions given over 2 h, a clearly prolonged increase in perfusion of the affected limb after LIPO-PGE1 was demonstrated. No serious adverse effects were observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050190
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