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  • V-ATPase  (1)
  • ergovaline  (1)
  • Springer  (2)
  • American Chemical Society
  • Annual Reviews
  • Blackwell Publishing Ltd
  • Molecular Diversity Preservation International
Collection
Keywords
Publisher
  • Springer  (2)
  • American Chemical Society
  • Annual Reviews
  • Blackwell Publishing Ltd
  • Molecular Diversity Preservation International
Years
  • 1
    Electronic Resource
    Electronic Resource
    Role of Intracellular pH in Proliferation, Transformation, and Apoptosis (1997)
    Springer
    Journal of bioenergetics and biomembranes 29 (1997), S. 393-399 
    Details
    ISSN: 1573-6881
    Keywords: Na+/H+ exchange ; proton pump ; V-ATPase ; anion exchange ; cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract Both cellular proliferation and apoptosis (programmed cell death) have been claimed to be modulated, perhaps even triggered by, changes in intracellular pH. In this review, we summarize the evidence that gave rise to these hypotheses. To facilitate a critical appraisal of the existing data, we briefly review the main pathways involved in cytosolic pH homeostasis and their regulation by mitogens and by apoptosis-inducing agents. The information available at present suggests that cytosolic pH plays a permissive role in cellular growth and proliferation, but is neither a trigger nor an essential step in the mitogenic signal transduction cascade. Concerning apoptosis, it is clear that lowering the pH in vitro can activate DNase II. However, the evidence linking cytosolic acidification with DNA degradation in vivois presently not convincing. We conclude that the cytosolic pH, an essential physiological parameter that is tightly controlled by multiple, complementary, or redundant systems, is unlikely to play a role in signalling either cell growth or death.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022407116339
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  • 2
    Electronic Resource
    Electronic Resource
    Fungal endophyte-infected grasses: Alkaloid accumulation and aphid response (1990)
    Springer
    Journal of chemical ecology 16 (1990), S. 3301-3315 
    Details
    ISSN: 1573-1561
    Keywords: Endophyte-infected grasses ; Acremonium ; endophytes ; Epichloe typhina ; grass alkaloids ; lolines ; ergovaline ; peramine ; lolitrem B ; aphid responses ; plant resistance to herbivory ; Rhopalosiphum padi ; Schizaphis graminum ; Homoptera ; Aphididae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The occurrence of the alkaloidsN-formyl andN-acetyl loline, peramine, lolitrem B, and ergovaline and the response of aphids to plants containing these compounds were determined in species and cultivars ofFestuca,Lolium, and other grass genera infected with fungal endophytes (Acremonium spp., andEpichloe typhina). Twenty-nine of 34 host-fungus associations produced one or more of the alkaloids, most frequently peramine or ergovaline. Three alkaloids (lolines, peramine, and ergovaline) were found in tall fescue and in perennial ryegrass infected withA. coenophialum, while peramine, lolitrem B, and ergovaline were present in perennial ryegrass and in tall fescue infected withA. lolii and inF. longifolia infected withE. typhina. WhileA. coenophialum andA. lolii produced similar patterns of alkaloids regardless of the species or cultivar of grass they infected, isolates ofE. typhina produced either no alkaloids or only one or two different alkaloids in the grasses tested. Aphid bioassays indicated thatRhopalosiphum padi andSchizaphis graminum did not survive on grasses containing loline alkaloids and thatS. graminum did not survive on peramine-containing grasses. Ergovaline-containing grasses did not affect either aphid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00982100
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