ISSN:
1432-0878
Keywords:
Mitochondria
;
Electron microscopy
;
Stereology
;
Number and volume
;
Lymphocytes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The authors ask the question whether the parameters “number” and “volume” are suitable for the morphometric analysis of mitochondria. In several types of cell, irregularity of mitochondrial shape makes it technically difficult, if not impossible, to obtain reliable stereological estimates of mean organelle volume or number per unit volume. Of more fundamental concern is whether number of mitochondria per cell is of any real value as a structural correlate of respiratory potential and hence as a measure of cell function. Alternative parameters might serve better for this purpose. Though the problem is illustrated by reference to quantitative studies of lymphocytes, it is also pertinent to the investigation of many other cell types.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00234641
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