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  • 1
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    Quantitative mass spectrometry identifies insulin signaling targets in C. elegans (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-08-04
    Description: DAF-2, an insulin receptor-like protein, regulates metabolism, development, and aging in Caenorhabditis elegans. In a quantitative proteomic study, we identified 86 proteins that were more or less abundant in long-lived daf-2 mutant worms than in wild-type worms. Genetic studies on a subset of these proteins indicated that they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage and aging. In particular, we discovered a compensatory mechanism activated in response to reduced DAF-2 signaling, which involves the protein phosphatase calcineurin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dong, Meng-Qiu -- Venable, John D -- Au, Nora -- Xu, Tao -- Park, Sung Kyu -- Cociorva, Daniel -- Johnson, Jeffrey R -- Dillin, Andrew -- Yates, John R 3rd -- DK067598/DK/NIDDK NIH HHS/ -- DK070696/DK/NIDDK NIH HHS/ -- DK074798/DK/NIDDK NIH HHS/ -- P41 RR11823-10/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2007 Aug 3;317(5838):660-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Scripps Research Institute, La Jolla, CA92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17673661" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/physiology ; Animals ; Caenorhabditis elegans/genetics/*metabolism/physiology ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Calcineurin/metabolism ; Carbohydrate Metabolism ; Gene Expression Regulation ; Genes, Helminth ; Longevity/physiology ; Mass Spectrometry/methods ; Models, Animal ; Mutation ; Proteomics ; RNA Interference ; Receptor, Insulin/genetics/*metabolism ; *Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    High-performance and scalable metal-chalcogenide semiconductors and devices via chalco-gel routes (2018)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2018-04-14
    Description: We report a general strategy for obtaining high-quality, large-area metal-chalcogenide semiconductor films from precursors combining chelated metal salts with chalcoureas or chalcoamides. Using conventional organic solvents, such precursors enable the expeditious formation of chalco-gels, which are easily transformed into the corresponding high-performance metal-chalcogenide thin films with large, uniform areas. Diverse metal chalcogenides and their alloys (MQ x : M = Zn, Cd, In, Sb, Pb; Q = S, Se, Te) are successfully synthesized at relatively low processing temperatures (〈400°C). The versatility of this scalable route is demonstrated by the fabrication of large-area thin-film transistors (TFTs), optoelectronic devices, and integrated circuits on a 4-inch Si wafer and 2.5-inch borosilicate glass substrates in ambient air using CdS, CdSe, and In 2 Se 3 active layers. The CdSe TFTs exhibit a maximum field-effect mobility greater than 300 cm 2 V –1 s –1 with an on/off current ratio of 〉10 7 and good operational stability (threshold voltage shift 〈 0.5 V at a positive gate bias stress of 10 ks). In addition, metal chalcogenide–based phototransistors with a photodetectivity of 〉10 13 Jones and seven-stage ring oscillators operating at a speed of ~2.6 MHz (propagation delay of 〈 27 ns per stage) are demonstrated.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A skin-like two-dimensionally pixelized full-color quantum dot photodetector (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Direct full-color photodetectors without sophisticated color filters and interferometric optics have attracted considerable attention for widespread applications. However, difficulties of combining various multispectral semiconductors and improving photon transfer efficiency for high-performance optoelectronic devices have impeded the translation of these platforms into practical realization. Here, we report a low-temperature (4.2 x 10〈sup〉17〈/sup〉 Jones) and photoresponsivity (〉8.3 x 10〈sup〉3〈/sup〉 A W〈sup〉–1〈/sup〉) in a broad range of wavelengths (365 to 1310 nm). On the basis of these technologies, a wavelength discriminable phototransistor circuit array (〉600 phototransistors) was implemented on a skin-like soft platform, which is expected to be a versatile and scalable approach for wide spectral image sensors and human-oriented biological devices.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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