Publication Date:
1990-05-25
Description:
Lesions of atherosclerosis occur in the innermost layer of the artery wall and consist primarily of proliferated smooth muscle cells surrounded by large amounts of connective tissue, numerous lipid-laden macrophages, and varying numbers of lymphocytes. Growth-regulatory molecules may be involved in intimal accumulation and proliferation of smooth muscle cells responsible for the occlusive lesions of atherosclerosis. Platelet-derived growth factor (PDGF) B-chain protein was found within macrophages in all stages of lesion development in both human and nonhuman primate atherosclerosis. Thus macrophages may play a critical role in the disease by providing PDGF, a potent chemotactic and growth-stimulatory molecule, to the intimal smooth muscle cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ross, R -- Masuda, J -- Raines, E W -- Gown, A M -- Katsuda, S -- Sasahara, M -- Malden, L T -- Masuko, H -- Sato, H -- HL-18645/HL/NHLBI NIH HHS/ -- HL-29873/HL/NHLBI NIH HHS/ -- RR-00166/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1990 May 25;248(4958):1009-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Washington, Seattle 98195.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2343305" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/immunology
;
Arteriosclerosis/*metabolism
;
Blotting, Northern
;
Diet, Atherogenic
;
Humans
;
Immunohistochemistry
;
Macaca nemestrina
;
Macrophages/*metabolism
;
Monocytes/metabolism
;
Platelet-Derived Growth Factor/genetics/*metabolism
;
RNA, Messenger/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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