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  • American Association for the Advancement of Science (AAAS)  (7)
  • 1
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    Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-17
    Description: Granulomas, organized aggregates of immune cells, are a hallmark of tuberculosis and have traditionally been thought to restrict mycobacterial growth. However, analysis of Mycobacterium marinum in zebrafish has shown that the early granuloma facilitates mycobacterial growth; uninfected macrophages are recruited to the granuloma where they are productively infected by M. marinum. Here, we identified the molecular mechanism by which mycobacteria induce granulomas: The bacterial secreted protein 6-kD early secreted antigenic target (ESAT-6), which has long been implicated in virulence, induced matrix metalloproteinase-9 (MMP9) in epithelial cells neighboring infected macrophages. MMP9 enhanced recruitment of macrophages, which contributed to nascent granuloma maturation and bacterial growth. Disruption of MMP9 function attenuated granuloma formation and bacterial growth. Thus, interception of epithelial MMP9 production could hold promise as a host-targeting tuberculosis therapy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125975/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125975/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Volkman, Hannah E -- Pozos, Tamara C -- Zheng, John -- Davis, J Muse -- Rawls, John F -- Ramakrishnan, Lalita -- F32 DK062675/DK/NIDDK NIH HHS/ -- F32 DK062675-02/DK/NIDDK NIH HHS/ -- F32 DK062675-03/DK/NIDDK NIH HHS/ -- K01 DK073695/DK/NIDDK NIH HHS/ -- K01 DK073695-01/DK/NIDDK NIH HHS/ -- K01 DK073695-02/DK/NIDDK NIH HHS/ -- K01 DK073695-03/DK/NIDDK NIH HHS/ -- K01 DK073695-04/DK/NIDDK NIH HHS/ -- R01 AI036396/AI/NIAID NIH HHS/ -- R01 AI036396-19/AI/NIAID NIH HHS/ -- R01 AI054503/AI/NIAID NIH HHS/ -- R01 AI054503-09/AI/NIAID NIH HHS/ -- R01 DK081426/DK/NIDDK NIH HHS/ -- R01 DK081426-01/DK/NIDDK NIH HHS/ -- R01 DK081426-02/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 22;327(5964):466-9. doi: 10.1126/science.1179663. Epub 2009 Dec 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98155, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20007864" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Bacterial/genetics/*metabolism ; Bacterial Proteins/genetics/*metabolism ; Disease Models, Animal ; Embryo, Nonmammalian/microbiology ; Enzyme Induction ; Epithelial Cells/*enzymology ; Granuloma/metabolism/*microbiology ; Macrophages/microbiology/physiology ; Matrix Metalloproteinase 9/genetics/*metabolism ; Mycobacterium Infections, Nontuberculous/*microbiology ; Mycobacterium marinum/growth & development/metabolism/*pathogenicity ; Mycobacterium tuberculosis/genetics/pathogenicity ; Oligoribonucleotides, Antisense ; Recombinant Proteins/metabolism ; Tuberculosis/*microbiology ; Virulence Factors/genetics/*metabolism ; Zebrafish/embryology ; Zebrafish Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Cocaine plasma concentration: relation to physiological and subjective effects in humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-13
    Description: Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Javaid, J I -- Fischman, M W -- Schuster, C R -- Dekirmenjian, H -- Davis, J M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):227-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694530" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intranasal ; Cocaine/administration & dosage/*blood/*pharmacology ; Dose-Response Relationship, Drug ; Euphoria/*drug effects ; Heart Rate/drug effects ; Humans ; Injections, Intravenous ; Kinetics ; Metabolic Clearance Rate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Schizophrenic symptoms improve with apomorphine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tamminga, C A -- Schaffer, M H -- Smith, R C -- Davis, J M -- New York, N.Y. -- Science. 1978 May 5;200(4341):567-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/347574" target="_blank"〉PubMed〈/a〉
    Keywords: Apomorphine/pharmacology/*therapeutic use ; Chronic Disease ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Male ; Nerve Endings/drug effects ; Receptors, Dopamine/drug effects ; Schizophrenia/*drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Lithium transport across red cell membrane: a cell membrane abnormality in manic-depressive illness (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: In the families of manic-depressive patients, relatives with a history of affective disorders had a significantly higher ratio of mean red cell lithium to plasma lithium in vitro than relatives with no such history. A genetically controlled abnormality in lithium-sodium transport, the mechanism that determines the lithium ratio, may play a role in the etiology of some forms of affective disorders.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dorus, E -- Pandey, G N -- Shaughnessy, R -- Gaviria, M -- Val, E -- Ericksen, S -- Davis, J M -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):932-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472716" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Transport ; Bipolar Disorder/blood/genetics/*metabolism ; Cations, Monovalent/metabolism ; Erythrocyte Membrane/*metabolism ; Erythrocytes/*metabolism ; Humans ; Lithium/*blood ; Pedigree ; Sodium/blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Certification for gene-edited forests (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Persistence of intense, climate-driven runoff late in Mars history (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Mars is dry today, but numerous precipitation-fed paleo-rivers are found across the planet’s surface. These rivers’ existence is a challenge to models of planetary climate evolution. We report results indicating that, for a given catchment area, rivers on Mars were wider than rivers on Earth today. We use the scale (width and wavelength) of Mars paleo-rivers as a proxy for past runoff production. Using multiple methods, we infer that intense runoff production of 〉(3–20) kg/m〈sup〉2〈/sup〉 per day persisted until 1 Ga. Our improved history of Mars’ river runoff places new constraints on the unknown mechanism that caused wet climates on Mars.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Discovery of orbital-selective Cooper pairing in FeSe (2017)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2017-07-07
    Description: The superconductor iron selenide (FeSe) is of intense interest owing to its unusual nonmagnetic nematic state and potential for high-temperature superconductivity. But its Cooper pairing mechanism has not been determined. We used Bogoliubov quasiparticle interference imaging to determine the Fermi surface geometry of the electronic bands surrounding the = (0, 0) and X = (/ a Fe , 0) points of FeSe and to measure the corresponding superconducting energy gaps. We show that both gaps are extremely anisotropic but nodeless and that they exhibit gap maxima oriented orthogonally in momentum space. Moreover, by implementing a novel technique, we demonstrate that these gaps have opposite sign with respect to each other. This complex gap configuration reveals the existence of orbital-selective Cooper pairing that, in FeSe, is based preferentially on electrons from the d yz orbitals of the iron atoms.
    Keywords: Physics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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