Publikationsdatum:
1997-12-31
Beschreibung:
Retroviral vectors containing CD4 and an appropriate chemokine receptor were evaluated for the ability to transduce cells infected with human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). These CD4-chemokine receptor pseudotypes were able to target HIV- and SIV-infected cell lines and monocyte-derived macrophages in a manner that corresponded to the specificity of the viral envelope glycoprotein for its CD4-chemokine receptor complex. This approach could offer a way to deliver antiviral genes directly to HIV-infected cells in vivo and could provide an additional treatment strategy in conjunction with existing antiviral therapies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Endres, M J -- Jaffer, S -- Haggarty, B -- Turner, J D -- Doranz, B J -- O'Brien, P J -- Kolson, D L -- Hoxie, J A -- AI33854/AI/NIAID NIH HHS/ -- AI40880/AI/NIAID NIH HHS/ -- HL 07439/HL/NHLBI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 Nov 21;278(5342):1462-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Hematology-Oncology Division, University of Pennsylvania, Philadelphia, PA 19104, USA. endres@mail.med.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9367958" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Antigens, CD4/*genetics/metabolism
;
Cell Line
;
Gene Products, env/metabolism
;
*Gene Transfer Techniques
;
*Genetic Vectors
;
HIV-1/*physiology
;
Humans
;
Macrophages/virology
;
Plasmids
;
Receptors, CCR5/genetics/metabolism
;
Receptors, CXCR4/genetics/metabolism
;
Receptors, Chemokine/*genetics/metabolism
;
Simian Immunodeficiency Virus/*physiology
;
Transfection
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
Permalink
