Publication Date:
2002-04-16
Description:
Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arase, Hisashi -- Mocarski, Edward S -- Campbell, Ann E -- Hill, Ann B -- Lanier, Lewis L -- AI30363/AI/NIAID NIH HHS/ -- CA89294/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 May 17;296(5571):1323-6. Epub 2002 Apr 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11950999" target="_blank"〉PubMed〈/a〉
Keywords:
3T3 Cells
;
Animals
;
Antigens, Ly/chemistry/genetics/*immunology/metabolism
;
Cell Line
;
Coculture Techniques
;
Disease Susceptibility
;
Evolution, Molecular
;
Herpesviridae Infections/*immunology
;
Histocompatibility Antigens Class I/immunology
;
Hybridomas
;
Immunity, Innate
;
Interferon-gamma/biosynthesis
;
Killer Cells, Natural/*immunology
;
Lectins, C-Type
;
Ligands
;
Lymphocyte Activation
;
Membrane Glycoproteins/chemistry/genetics/*immunology/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Mice, Inbred Strains
;
Muromegalovirus/genetics/*immunology/metabolism
;
NK Cell Lectin-Like Receptor Subfamily A
;
Protein Binding
;
Receptors, Immunologic/chemistry/genetics/*immunology/metabolism
;
Receptors, NK Cell Lectin-Like
;
Recombinant Fusion Proteins/metabolism
;
Transfection
;
Viral Proteins/chemistry/genetics/*immunology/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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