Publication Date:
1983-08-26
Description:
Superior cervical ganglia, whose vessels are fenestrated and permeable to protein tracers such as horseradish peroxidase, were transplanted to undamaged surfaces in the fourth ventricle of rat pup brains. Horseradish peroxidase, infused systemically into the host, was exuded from the graft's vessels into the graft's extracellular stroma within 1 minute. At later times the glycoprotein reached the extracellular clefts of adjacent brain tissue, the vessels of which appeared to retain their impermeability. The blood-brain barrier to horseradish peroxide was thus bypassed where the extracellular compartments of graft and brain became confluent. The graft of autonomic ganglia can serve as a portal through which peptides, hormones, and immunoglobulins may likewise enter the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenstein, J M -- Brightman, M W -- NS-17468/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):879-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879186" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Blood-Brain Barrier
;
Cerebral Ventricles/*physiology
;
Ganglia, Autonomic/blood supply/physiology/*transplantation
;
Horseradish Peroxidase
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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