Publication Date:
1990-02-02
Description:
The SCID-hu mouse, engrafted with human hematolymphoid organs, is permissive for infection with the human immunodeficiency virus (HIV). This mouse model was used to test compounds for antiviral efficacy. Two weeks after infection with HIV, 100 percent (40/40) of SCID-hu mice were positive for HIV by the polymerase chain reaction. When first treated with 3'-azido-3'-deoxythymidine (AZT), none (0/17) were HIV-positive by this assay. However, AZT-treated SCID-hu mice did have a few infected cells; after AZT treatment was stopped, viral spread was detected by polymerase chain reaction in such mice. Thus, the SCID-hu mouse provides a means to directly compare new antiviral compounds with AZT and to further improve antiviral efficacy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCune, J M -- Namikawa, R -- Shih, C C -- Rabin, L -- Kaneshima, H -- New York, N.Y. -- Science. 1990 Feb 2;247(4942):564-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉HIV Group, SyStemix, Palo Alto, CA 94303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2300816" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
DNA, Viral/genetics/isolation & purification
;
HIV/drug effects/genetics/isolation & purification
;
HIV Infections/*drug therapy
;
Humans
;
Mice
;
Mice, Mutant Strains
;
Nucleic Acid Hybridization
;
Polymerase Chain Reaction
;
Spleen/microbiology
;
Thymus Gland/microbiology/transplantation
;
Transplantation, Heterologous
;
Zidovudine/*therapeutic use
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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