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  • Mice  (14)
  • Mice, Knockout  (3)
  • Mice, Transgenic  (3)
  • American Association for the Advancement of Science (AAAS)  (14)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (14)
Years
  • 1
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    Obesity drug pipeline not so fat (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2003 Feb 7;299(5608):849-52.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12574616" target="_blank"〉PubMed〈/a〉
    Keywords: Agouti-Related Protein ; Animals ; Anti-Obesity Agents/adverse effects/pharmacology/*therapeutic use ; Appetite/drug effects ; Arcuate Nucleus of Hypothalamus/metabolism ; Ciliary Neurotrophic Factor/therapeutic use ; Clinical Trials as Topic ; Cyclobutanes/adverse effects/therapeutic use ; Energy Intake ; Ghrelin ; Humans ; Hunger/drug effects ; Intercellular Signaling Peptides and Proteins ; Lactones/adverse effects/therapeutic use ; Leptin/metabolism/therapeutic use ; Mice ; Nerve Tissue Proteins/adverse effects/therapeutic use ; Neurons/metabolism ; Neuropeptide Y/metabolism/pharmacology ; Obesity/*drug therapy/metabolism ; Peptide Fragments ; Peptide Hormones/metabolism/pharmacology ; Peptide YY/metabolism/pharmacology ; Phentermine/adverse effects/therapeutic use ; Proteins/metabolism ; Receptors, Corticotropin/metabolism ; Receptors, Melanocortin ; Weight Loss ; alpha-MSH/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Obesity. Enzyme blocker prompts mice to shed weight (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-05
    Description: A multidisciplinary team may have discovered an important new weapon in the battle of the bulge. On page 2379 of this issue, the team reports that a molecule that is needed for fat synthesis in the body may play a key role in appetite signaling in the brain. Moreover, the investigators produced a synthetic inhibitor of this molecule that spurred a dramatic drop in appetite and weight in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2000 Jun 30;288(5475):2299-300.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10917820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite/drug effects ; Appetite Depressants/*pharmacology ; Brain/metabolism ; Enzyme Inhibitors/*pharmacology ; Fasting ; Fatty Acid Synthases/*antagonists & inhibitors ; Humans ; Liver/drug effects/metabolism ; Malonyl Coenzyme A/metabolism ; Mice ; Neuropeptide Y/genetics/metabolism ; Obesity/*drug therapy ; RNA, Messenger/genetics/metabolism ; Weight Loss/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Obesity research. Pot-bellied mice point to obesity enzyme (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2001 Dec 7;294(5549):2071-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11739926" target="_blank"〉PubMed〈/a〉
    Keywords: 11-beta-Hydroxysteroid Dehydrogenase Type 2 ; Abdomen ; Adipose Tissue/*enzymology/metabolism ; Animals ; Body Composition ; Diabetes Mellitus/enzymology/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Hydrocortisone/blood/*metabolism ; Hydroxysteroid Dehydrogenases/antagonists & inhibitors/genetics/*metabolism ; Hypoglycemic Agents/pharmacology ; Male ; Metabolic Syndrome X ; Mice ; Mice, Transgenic ; Obesity/*enzymology/genetics/metabolism ; Skin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Gene defect linked to Rett syndrome (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):27.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10532886" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosomal Proteins, Non-Histone ; Chromosome Mapping ; DNA-Binding Proteins/*genetics ; Female ; *Gene Expression Regulation ; Humans ; Male ; Methyl-CpG-Binding Protein 2 ; Mice ; Mice, Knockout ; Mutation ; Repressor Proteins/*genetics ; Rett Syndrome/*genetics ; X Chromosome/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    New lead found to a possible "insulin pill" (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 May 7;284(5416):886.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10357667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascomycota/*metabolism ; CHO Cells ; Cricetinae ; Diabetes Mellitus, Type 2/*drug therapy ; Drug Evaluation, Preclinical ; Hypoglycemic Agents/chemistry/isolation & purification/metabolism/*therapeutic ; use ; Indoles/chemistry/isolation & purification/metabolism/*therapeutic use ; Insulin/metabolism/pharmacology ; Mice ; Mice, Mutant Strains ; Receptor, Insulin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Chlamydia protein linked to heart disease (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1999 Feb 26;283(5406):1238-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10084921" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoimmune Diseases/immunology/microbiology ; Bacterial Proteins/*immunology ; Chlamydia/*immunology/metabolism ; Chlamydia Infections/complications/immunology ; Heart/microbiology ; Humans ; Mice ; *Molecular Mimicry ; Myocarditis/immunology/*microbiology ; Myocardium/*immunology ; Myosins/*immunology ; Peptides/immunology ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Neurobiology. Trigger found for synapse formation (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-07-06
    Description: Until now, neurobiologists have had little luck in finding the matchmakers of nerve cell connections, called synapses, in the brain. In today's issue of Cell, researchers report that a single protein can apparently trigger synapse formation between brain neurons isolated from mice and grown in culture. If the finding is borne out in living animals, it could provide fresh insights into how the brain is wired during embryonic development and might eventually provide new ways to enhance or at least maintain synapse formation in the brains of patients suffering from neurodegenerative diseases such as Parkinson's or Alzheimer's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 2000 Jun 9;288(5472):1718-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10877681" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology ; Cell Adhesion Molecules, Neuronal ; Cells, Cultured ; Membrane Proteins/analysis/genetics/*metabolism ; Mice ; Mice, Knockout ; Nerve Tissue Proteins/analysis/genetics/*metabolism ; Neurons/*physiology ; Synapses/*physiology ; Synaptic Membranes/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Genomics. After the gold rush: gene firms reinvent themselves (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, Trisha -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):1982-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242421" target="_blank"〉PubMed〈/a〉
    Keywords: Access to Information ; Animals ; *Biotechnology/economics ; Chemistry, Pharmaceutical ; Clinical Trials as Topic ; Computational Biology ; Databases, Genetic ; Disease Models, Animal ; *Drug Design ; *Drug Industry/economics ; *Genomics/economics ; Humans ; Investments ; Mice ; *Pharmaceutical Preparations ; Private Sector ; Public Sector
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    How embryos may avoid immune attack (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-09-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1998 Aug 21;281(5380):1122-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9735025" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Embryo, Mammalian/*immunology ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; *Immune Tolerance ; Male ; Mice ; Placenta/enzymology ; Pregnancy ; T-Lymphocytes/*immunology/metabolism ; Trophoblasts/*enzymology ; Tryptophan/analogs & derivatives/*metabolism/pharmacology ; Tryptophan Oxygenase/antagonists & inhibitors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    From fat-free mice, the skinny on diabetes (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-12-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gura, T -- New York, N.Y. -- Science. 1998 Oct 23;282(5389):604.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9841407" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/*physiology ; Animals ; Chromans/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy/*etiology/physiopathology ; Fatty Acids/metabolism ; Humans ; Hypoglycemic Agents/therapeutic use ; Lipodystrophy/drug therapy ; Mice ; Mice, Transgenic ; Thiazoles/therapeutic use ; *Thiazolidinediones ; Transcription Factors/genetics/physiology ; Triglycerides/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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