Publication Date:
1987-11-20
Description:
A very unusual molecular mechanism is involved in generating the preimmune repertoire in the chicken bursa of Fabricius. A unique rearranged V gene is diversified through a program of segmental gene conversion with a pool of noncoding pseudogenes being used as donors. A specifically committed progenitor that originates in the embryonic bursa is responsible for long-term maintenance of the B cell population. Both these properties and the characteristics of the peripheral B cell compartment are discussed in terms of the evolution of the T and B immune systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weill, J C -- Reynaud, C A -- New York, N.Y. -- Science. 1987 Nov 20;238(4830):1094-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Jacques Monod, CNRS, Universite Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3317827" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibody Diversity
;
B-Lymphocytes/*immunology
;
Bursa of Fabricius/embryology/*immunology
;
Chickens/*immunology
;
*Genes, Immunoglobulin
;
Immunoglobulin Variable Region/genetics
;
Immunoglobulins/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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