Publication Date:
1978-01-20
Description:
The spinal fluid of sheep with experimental allergic encephalomyelitis contains myelin basic protein (6 to 18 nanograms per milliliter) bound to antibody as well as excess free antibody. This bound myelin basic protein appeared concurrently with the onset of the disease and remained elevated until death. In contrast, in active multiple sclerosis, the spinal fluid contains free myelin basic protein and there are no detectable levels of antibody. The results indicate that the antibodies enter the spinal fluid from the serum by passive diffusion. This mechanism may also explain the presence of viral antibodies in the spinal fluid of multiple sclerosis patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gutstein, H S -- Cohen, S R -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619457" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Antibody Complex
;
Autoantibodies/*cerebrospinal fluid
;
Encephalomyelitis, Autoimmune, Experimental/*cerebrospinal fluid/immunology
;
Humans
;
Multiple Sclerosis/*cerebrospinal fluid/immunology
;
Myelin Proteins/*cerebrospinal fluid/immunology
;
Sheep
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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