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  • Animals  (2)
  • Atmospheric Science, Geochemistry, Geophysics  (1)
  • American Association for the Advancement of Science (AAAS)  (3)
  • 1
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    Autoimmune diseases: the failure of self tolerance (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-06-15
    Description: The ability to discriminate between self and nonself antigens is vital to the functioning of the immune system as a specific defense against invading microorganisms. Failure of the immune system to "tolerate" self tissues can result in pathological autoimmune states leading to debilitating illness and sometimes death. The induction of autoimmunity involves genetic and environmental factors that have focused the attention of researchers on the trimolecular complex formed by major histocompatibility complex molecules, antigen, and T cell receptors. Detailed molecular characterization of these components points to potential strategies for disease intervention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sinha, A A -- Lopez, M T -- McDevitt, H O -- New York, N.Y. -- Science. 1990 Jun 15;248(4961):1380-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1972595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantibodies/immunology ; Autoantigens/immunology ; Autoimmune Diseases/chemically induced/*immunology ; B-Lymphocytes/immunology ; Bacterial Infections/immunology ; Biological Factors/physiology ; CD4-Positive T-Lymphocytes/immunology ; Cytokines ; Gene Rearrangement, T-Lymphocyte ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/immunology ; Humans ; *Immune Tolerance ; Major Histocompatibility Complex ; Mice ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Receptors, Antigen, T-Cell/genetics/immunology ; T-Lymphocytes, Regulatory/immunology ; *Virus Diseases/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Specific immunosuppression by immunotoxins containing daunomycin (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-01-10
    Description: Daunomycin, when conjugated with a targeting antigen by an acid-sensitive spacer, remains inactive at the intravascular pH of 7 but becomes active after cleavage within the acidic lysosomal environment of the target cell. This observation made it possible to construct cytocidal compounds that caused antigen-specific suppression of murine lymphocyte function. When daunomycin was coupled to the hapten conjugate of ovalbumin by an acid-sensitive cis-aconityl group, it caused hapten-specific impairment of immunocompetence in murine B lymphocytes in vitro and in vivo. Furthermore, the response by T lymphocytes to concanavalin A in vitro was selectively eliminated by a conjugate between daunomycin plus the acid-sensitive spacer and a monoclonal antibody specific for T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diener, E -- Diner, U E -- Sinha, A -- Xie, S -- Vergidis, R -- New York, N.Y. -- Science. 1986 Jan 10;231(4734):148-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3484557" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoimmune Diseases/therapy ; Concanavalin A/pharmacology ; Daunorubicin/*administration & dosage/pharmacology ; Fluorescein ; Fluoresceins/administration & dosage/pharmacology ; *Immunosuppression ; Immunosuppressive Agents/*pharmacology ; Lymphocyte Activation/drug effects ; Mice ; Mice, Inbred CBA ; Nitrohydroxyiodophenylacetate/administration & dosage/pharmacology ; Ovalbumin/administration & dosage/pharmacology ; Picrates/administration & dosage/pharmacology ; Spleen/cytology ; T-Lymphocytes/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Atmospheric 14C/12C changes during the last glacial period from Hulu Cave (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-12-14
    Description: Paired measurements of 14 C/ 12 C and 230 Th ages from two Hulu Cave stalagmites complete a precise record of atmospheric 14 C covering the full range of the 14 C dating method (~54,000 years). Over the last glacial period, atmospheric 14 C/ 12 C ranges from values similar to modern values to values 1.70 times higher (42,000 to 39,000 years ago). The latter correspond to 14 C ages 5200 years less than calibrated ages and correlate with the Laschamp geomagnetic excursion followed by Heinrich Stadial 4. Millennial-scale variations are largely attributable to Earth’s magnetic field changes and in part to climate-related changes in the oceanic carbon cycle. A progressive shift to lower 14 C/ 12 C values between 25,000 and 11,000 years ago is likely related, in part, to progressively increasing ocean ventilation rates.
    Keywords: Atmospheric Science, Geochemistry, Geophysics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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