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  • Humans  (8)
  • Aedes/*parasitology/physiology  (2)
  • Chemistry  (2)
  • Analytical Chemistry and Spectroscopy
  • SPACE SCIENCES
  • American Association for the Advancement of Science (AAAS)  (12)
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  • 1
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    The difficulties of double blinding (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercer, Jean -- New York, N.Y. -- Science. 2002 Sep 27;297(5590):2208.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12353521" target="_blank"〉PubMed〈/a〉
    Keywords: *Double-Blind Method ; *Estrogen Replacement Therapy/adverse effects ; Female ; Humans ; Patient Compliance ; Placebos ; *Randomized Controlled Trials as Topic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Unlocking P(V): Reagents for chiral phosphorothioate synthesis (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-09-21
    Description: Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic use of phosphorus(III) [P(III)]–based reagent systems as the sole practical means of oligonucleotide assembly. A fundamentally different approach is described herein: the invention of a P(V)-based reagent platform for programmable, traceless, diastereoselective phosphorus-sulfur incorporation. The power of this reagent system is demonstrated through the robust and stereocontrolled synthesis of various nucleotidic architectures, including ASOs and CDNs, via an efficient, inexpensive, and operationally simple protocol.
    Keywords: Chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Regulatory role of parasites: impact on host population shifts with resource availability (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-07-12
    Description: Effects of infections by the ciliate Lambornella clarki on larval populations of its mosquito host Aedes sierrensis were examined in laboratory and field studies. When host populations developed with sufficient food, mortality from parasites was additive and reduced the number of emerging mosquitoes. For food-limited populations, mortality was compensatory or depensatory; emerging adults were as or more abundant with higher average fitness than those from uninfected control populations. When nutrients were scarce, parasitic infections relaxed larval competition and increased per capita food by reducing host abundance. Food limitation altered larval feeding behavior, reducing horizontal transmission and subsequent mortality from parasitism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Washburn, J O -- Mercer, D R -- Anderson, J R -- AI20245/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1991 Jul 12;253(5016):185-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1906637" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/*parasitology/physiology ; Animals ; Ciliophora/*physiology ; Ecology ; Population Dynamics ; Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Minding controls in curriculum study (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-03-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercer, Jean -- New York, N.Y. -- Science. 2008 Feb 29;319(5867):1185-6; author reply 1185-6. doi: 10.1126/science.319.5867.1185.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18309062" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child, Preschool ; *Cognition ; *Curriculum ; *Early Intervention (Education) ; Faculty ; Humans ; *Interpersonal Relations ; *Schools, Nursery
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    SPORE series winner. Immunology for clinicians: a "Trojan Horse" approach (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-10-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, Clive M -- Loubser, Shayne -- Kriel, Carina -- Mercer, Monica -- Brookes, Heather -- New York, N.Y. -- Science. 2010 Sep 24;329(5999):1613-4. doi: 10.1126/science.1186963.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute for Communicable Diseases, National Health Laboratory Services, Johannesburg, South Africa. cgray@nicd.ac.za〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20929838" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Allergy and Immunology/*education ; Awards and Prizes ; Child ; Child, Preschool ; *Education, Medical, Continuing ; HIV Infections/diagnosis/epidemiology/*immunology/therapy ; Humans ; Infant ; Infant, Newborn ; *Internet ; *Internship and Residency ; Pediatrics/education ; South Africa
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Predator-induced trophic shift of a free-living ciliate: parasitism of mosquito larvae by their prey (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-05-27
    Description: Larvae of the treehole mosquito, Aedes sierrensis, release a waterborne factor that induces morphogenesis of one of their prey, the tetrahymenid ciliate Lambornella clarki. Induced free-living trophonts of L. clarki undergo a synchronous response in which cells divide and transform into parasitic cells (theronts) that encyst on larval predators. Parasitic ciliates penetrate the cuticle, enter the hemocoel, and ultimately kill their predator-host. In nature, this trophic shift can lead to predator extinction and dramatic changes in microbial populations. Facultative parasitism by this polymorphic ciliate may have evolved as an antipredator strategy. The experimentally inducible parasitic response of L. clarki provides a novel model for studying cellular morphogenesis of ciliated protozoa.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Washburn, J O -- Gross, M E -- Mercer, D R -- Anderson, J R -- AI20245/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1988 May 27;240(4856):1193-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomological Sciences, University of California, Berkely 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3131877" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/*parasitology/physiology ; Animals ; Ciliophora/growth & development/*physiology ; Ecology ; Larva ; Predatory Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    One woman's balancing act (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-12-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercer, Jean -- New York, N.Y. -- Science. 2007 Dec 21;318(5858):1864-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18096788" target="_blank"〉PubMed〈/a〉
    Keywords: *Faculty ; Family ; Female ; Humans ; *Internet ; *Interprofessional Relations ; *Women, Working
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    The eukaryotic genome as an RNA machine (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-03-29
    Description: The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of non-protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. Here, we highlight recent advances that illustrate the diversity of ncRNA control of genome dynamics, cell biology, and developmental programming.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amaral, Paulo P -- Dinger, Marcel E -- Mercer, Tim R -- Mattick, John S -- New York, N.Y. -- Science. 2008 Mar 28;319(5871):1787-9. doi: 10.1126/science.1155472.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Molecular Bioscience, University of Queensland, St. Lucia QLD 4072, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18369136" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Eukaryotic Cells/*metabolism ; Evolution, Molecular ; *Gene Expression Regulation ; Genome ; Genome, Human ; Humans ; Protein Biosynthesis ; RNA Processing, Post-Transcriptional ; RNA, Untranslated/*genetics/metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-04-26
    Description: Viruses employ many different strategies to enter host cells. Vaccinia virus, a prototype poxvirus, enters cells in a pH-dependent fashion. Live cell imaging showed that fluorescent virus particles associated with and moved along filopodia to the cell body, where they were internalized after inducing the extrusion of large transient membrane blebs. p21-activated kinase 1 (PAK1) was activated by the virus, and the endocytic process had the general characteristics of macropinocytosis. The induction of blebs, the endocytic event, and infection were all critically dependent on the presence of exposed phosphatidylserine in the viral membrane, which suggests that vaccinia virus uses apoptotic mimicry to enter cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercer, Jason -- Helenius, Ari -- New York, N.Y. -- Science. 2008 Apr 25;320(5875):531-5. doi: 10.1126/science.1155164.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉ETH Zurich, Institute of Biochemistry, Schafmattstrasse 18, ETH Honggerberg HPM E6.3 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18436786" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; Animals ; *Apoptosis ; Cell Membrane/*metabolism/ultrastructure ; Humans ; Phosphatidylserines/*metabolism ; *Pinocytosis ; RNA Interference ; Vaccinia virus/*physiology ; *Virus Internalization ; p21-Activated Kinases/genetics/metabolism ; rac1 GTP-Binding Protein/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Martial arts research: weak evidence (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-10-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercer, Jean -- New York, N.Y. -- Science. 2011 Oct 21;334(6054):310-1; author reply 311. doi: 10.1126/science.334.6054.310-c.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22021838" target="_blank"〉PubMed〈/a〉
    Keywords: *Executive Function ; Female ; Humans ; Male
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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