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  • Animals  (8)
  • *Tropical Climate
  • ASTROPHYSICS
  • carbamazepine
  • American Association for the Advancement of Science (AAAS)  (8)
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  • 1
    Publication Date: 2002-08-24
    Description: Populations of the garter snake Thamnophis sirtalis have evolved geographically variable resistance to tetrodotoxin (TTX) in a coevolutionary arms race with their toxic prey, newts of the genus Taricha. Here, we identify a physiological mechanism, the expression of TTX-resistant sodium channels in skeletal muscle, responsible for adaptive diversification in whole-animal resistance. Both individual and population differences in the ability of skeletal muscle fibers to function in the presence of TTX correlate closely with whole-animal measures of TTX resistance. Demonstration of individual variation in an essential physiological function responsible for the adaptive differences among populations is a step toward linking the selective consequences of coevolutionary interactions to geographic and phylogenetic patterns of diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geffeney, Shana -- Brodie, Edmund D Jr -- Ruben, Peter C -- Brodie, Edmund D 3rd -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1336-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Utah State University, Logan, UT 84322, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193784" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Adaptation, Physiological ; Animals ; *Biological Evolution ; Colubridae/*physiology ; Drug Resistance ; Linear Models ; Locomotion/drug effects ; Muscle Fibers, Skeletal/drug effects/physiology ; Muscle, Skeletal/drug effects/*physiology ; Neuromuscular Junction/drug effects/physiology ; Predatory Behavior ; *Salamandridae/metabolism ; Skin/chemistry ; Sodium Channels/*drug effects/physiology ; Tetrodotoxin/*toxicity ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2004-04-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, Kevin V -- Brodie, Edmund D Jr -- Brodie, Edmund D 3rd -- New York, N.Y. -- Science. 2004 Apr 2;304(5667):65.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Utah State University, Logan, UT 84322-5305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001716" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Lizards/*anatomy & histology ; Male ; *Predatory Behavior ; *Selection, Genetic ; *Songbirds
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2001-06-02
    Description: In many animal species, the amount of care provided by parents is determined through a complex interaction of offspring signals and responses by parents to those signals. As predicted by honest signaling theory, we show that in the burrower bug, Sehirus cinctus, maternal provisioning responds to experimental manipulations of offspring condition. Despite this predicted environmental influence, we find evidence from two cross-foster experiments that variation in maternal care also stems from two distinct genetic sources: variation among offspring in their ability to elicit care and variation among parents in their response to offspring signals. Furthermore, as predicted by maternal-offspring coadaptation theory, offspring signaling is negatively genetically correlated with maternal provisioning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Agrawal, A F -- Brodie, E D 3rd -- Brown, J -- New York, N.Y. -- Science. 2001 Jun 1;292(5522):1710-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN 47405-3700, USA. aagrawal@bio.indiana.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11387474" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Physiological ; Animals ; Biological Evolution ; Cues ; Feeding Behavior ; Female ; *Genetic Variation ; Hemiptera/*genetics/*physiology ; *Maternal Behavior ; Phenotype
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1992-06-12
    Description: Potent immunological adjuvants are urgently required to complement recombinant and synthetic vaccines. However, it has not been possible to derive new principles for the design of vaccine adjuvants from knowledge of the mechanism of immunogenicity. Carbonyl-amino condensations, which are essential to the inductive interaction between antigen-presenting cells and T helper cells, were tested as a target for the enhancement of immune responses. Enzymic oxidation of cell-surface galactose to increase aminereactive carbonyl groups on murine lymphocytes and antigen-presenting cells provided a potent, noninflammatory method of enhancing the immunogenicity of viral, bacterial, and protozoal subunit vaccines in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zheng, B -- Brett, S J -- Tite, J P -- Lifely, M R -- Brodie, T A -- Rhodes, J -- New York, N.Y. -- Science. 1992 Jun 12;256(5063):1560-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1598588" target="_blank"〉PubMed〈/a〉
    Keywords: *Adjuvants, Immunologic ; Animals ; Antibody Formation ; Cytotoxicity, Immunologic ; Galactose/*metabolism ; Galactose Oxidase/*administration & dosage ; HIV Envelope Protein gp120/immunology ; Lymphocyte Activation ; Mice ; Neuraminidase/administration & dosage ; Oxidation-Reduction ; Peptides/immunology ; T-Lymphocytes/*immunology ; Vaccination/*methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2006-07-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mendelson, Joseph R 3rd -- Lips, Karen R -- Gagliardo, Ronald W -- Rabb, George B -- Collins, James P -- Diffendorfer, James E -- Daszak, Peter -- Ibanez D, Roberto -- Zippel, Kevin C -- Lawson, Dwight P -- Wright, Kevin M -- Stuart, Simon N -- Gascon, Claude -- da Silva, Helio R -- Burrowes, Patricia A -- Joglar, Rafael L -- La Marca, Enrique -- Lotters, Stefan -- du Preez, Louis H -- Weldon, Che -- Hyatt, Alex -- Rodriguez-Mahecha, Jose Vicente -- Hunt, Susan -- Robertson, Helen -- Lock, Brad -- Raxworthy, Christopher J -- Frost, Darrel R -- Lacy, Robert C -- Alford, Ross A -- Campbell, Jonathan A -- Parra-Olea, Gabriela -- Bolanos, Federico -- Domingo, Jose Joaquin Calvo -- Halliday, Tim -- Murphy, James B -- Wake, Marvalee H -- Coloma, Luis A -- Kuzmin, Sergius L -- Price, Mark Stanley -- Howell, Kim M -- Lau, Michael -- Pethiyagoda, Rohan -- Boone, Michelle -- Lannoo, Michael J -- Blaustein, Andrew R -- Dobson, Andy -- Griffiths, Richard A -- Crump, Martha L -- Wake, David B -- Brodie, Edmund D Jr -- New York, N.Y. -- Science. 2006 Jul 7;313(5783):48.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zoo Atlanta, 800 Cherokee Avenue SE, Atlanta, GA 30315, USA. jmendelson@zooatlanta.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16825553" target="_blank"〉PubMed〈/a〉
    Keywords: *Amphibians ; Animals ; *Biodiversity ; Chytridiomycota ; Conservation of Natural Resources ; Ecosystem ; *International Agencies ; International Cooperation ; Mycoses/veterinary ; Population Dynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2009-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brodie, Jedediah F -- Gibbs, Holly K -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):364-5. doi: 10.1126/science.326_364b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wildlife Biology Program, University of Montana, Missoula, MT 59802, USA. jedediah.brodie@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833939" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Animals ; *Climatic Processes ; *Conservation of Natural Resources ; *Ecosystem ; Extinction, Biological ; Meat ; Population Dynamics ; *Tropical Climate ; *Vertebrates
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2013-08-03
    Description: After a decade with nine of the lowest arctic sea-ice minima on record, including the historically low minimum in 2012, we synthesize recent developments in the study of ecological responses to sea-ice decline. Sea-ice loss emerges as an important driver of marine and terrestrial ecological dynamics, influencing productivity, species interactions, population mixing, gene flow, and pathogen and disease transmission. Major challenges in the near future include assigning clearer attribution to sea ice as a primary driver of such dynamics, especially in terrestrial systems, and addressing pressures arising from human use of arctic coastal and near-shore areas as sea ice diminishes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Post, Eric -- Bhatt, Uma S -- Bitz, Cecilia M -- Brodie, Jedediah F -- Fulton, Tara L -- Hebblewhite, Mark -- Kerby, Jeffrey -- Kutz, Susan J -- Stirling, Ian -- Walker, Donald A -- New York, N.Y. -- Science. 2013 Aug 2;341(6145):519-24. doi: 10.1126/science.1235225.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Polar Center, and Department of Biology, Pennsylvania State University, University Park, PA 16802, USA. esp10@psu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23908231" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aquatic Organisms ; Arctic Regions ; *Climate Change ; Humans ; *Ice Cover ; Invertebrates ; Plant Development ; *Seawater ; Vertebrates
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 1983-08-12
    Description: The polyamine metabolism of transplanted N-nitrosomethylurea-derived rat glioma was determined with radiolabeled putrescine used as a marker for malignancy. The uptake of putrescine in vivo was complete within 5 minutes and was specific for tumor tissue. The conversion of putrescine to spermine and other metabolites by the tumor was rapid, in contrast to the case for adjacent normal brain. These results suggest that putrescine labeled with carbon-11 may be used as a positron-emission tomographic tracer for the selective metabolic imaging of brain tumor and may be used in an appropriate model as a marker for tumor growth rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Volkow, N -- Goldman, S S -- Flamm, E S -- Cravioto, H -- Wolf, A P -- Brodie, J D -- NS15638/NS/NINDS NIH HHS/ -- S07RR05399/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):673-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603020" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Brain Neoplasms/*radionuclide imaging ; Glioma/radionuclide imaging ; Kinetics ; Neoplasm Transplantation ; *Putrescine/metabolism ; Rats ; Tomography, Emission-Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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