Publication Date:
1989-06-02
Description:
The scanning tunneling microscope can image uncoated DNA submerged in water. The grooves of the double helix were clearly resolved in images of the 146-base pair fragment extracted from calf thymus nucleosome. In contrast to images obtained with dry DNA, the helix pitch varied only a small amount (36 +/- 5 angstroms). The path of the helix shows considerable variation. It is quite straight when the molecules are densely packed, but it curves and bends in isolated molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lindsay, S M -- Thundat, T -- Nagahara, L -- Knipping, U -- Rill, R L -- New York, N.Y. -- Science. 1989 Jun 2;244(4908):1063-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Arizona State University, Tempe 85287.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2727694" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Composition
;
Cattle
;
DNA/*ultrastructure
;
*Microscopy, Electron
;
*Nucleic Acid Conformation
;
Nucleosomes/analysis
;
Solutions
;
Thymus Gland/ultrastructure
;
*Water
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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